Increased risk of essential tremor in first-degree relatives of patients with Parkinson's disease.
Identifieur interne : 002659 ( PubMed/Curation ); précédent : 002658; suivant : 002660Increased risk of essential tremor in first-degree relatives of patients with Parkinson's disease.
Auteurs : Walter A. Rocca [États-Unis] ; James H. Bower ; J Eric Ahlskog ; Alexis Elbaz ; Brandon R. Grossardt ; Shannon K. Mcdonnell ; Daniel J. Schaid ; Demetrius M. MaraganoreSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Age Factors, Aged, Aged, 80 and over, Cohort Studies, Confidence Intervals, Essential Tremor (epidemiology), Essential Tremor (etiology), Essential Tremor (genetics), Family Health, Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Proportional Hazards Models, Retrospective Studies, Risk, Sex Factors.
- MESH :
- complications : Parkinson Disease.
- epidemiology : Essential Tremor, Parkinson Disease.
- etiology : Essential Tremor.
- genetics : Essential Tremor, Parkinson Disease.
- Age Factors, Aged, Aged, 80 and over, Cohort Studies, Confidence Intervals, Family Health, Female, Humans, Male, Middle Aged, Proportional Hazards Models, Retrospective Studies, Risk, Sex Factors.
Abstract
We conducted a historical cohort study of 981 first-degree relatives of 162 patients with Parkinson's disease (PD) and of 838 first-degree relatives of 147 controls representative of the population of Olmsted County, Minnesota. In addition, we studied 2,684 first-degree relatives of 411 patients with PD referred to the Mayo Clinic. Relatives were interviewed and screened for tremor either directly or through a proxy, and those who screened positive were examined or copies of their medical records were obtained to confirm the diagnosis of essential tremor (ET). We also obtained ET information from a medical records-linkage system (family study method). In the population-based sample, the risk of ET was significantly increased for relatives of patients with onset of PD
DOI: 10.1002/mds.21584
PubMed: 17546668
DOI: 10.1002/mds.21584
PubMed: 17546668
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pubmed:17546668Le document en format XML
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<author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M" last="Maraganore">Demetrius M. Maraganore</name>
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<term>Aged</term>
<term>Aged, 80 and over</term>
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<term>Confidence Intervals</term>
<term>Essential Tremor (epidemiology)</term>
<term>Essential Tremor (etiology)</term>
<term>Essential Tremor (genetics)</term>
<term>Family Health</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Proportional Hazards Models</term>
<term>Retrospective Studies</term>
<term>Risk</term>
<term>Sex Factors</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Essential Tremor</term>
<term>Parkinson Disease</term>
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<term>Aged, 80 and over</term>
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<term>Confidence Intervals</term>
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<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">We conducted a historical cohort study of 981 first-degree relatives of 162 patients with Parkinson's disease (PD) and of 838 first-degree relatives of 147 controls representative of the population of Olmsted County, Minnesota. In addition, we studied 2,684 first-degree relatives of 411 patients with PD referred to the Mayo Clinic. Relatives were interviewed and screened for tremor either directly or through a proxy, and those who screened positive were examined or copies of their medical records were obtained to confirm the diagnosis of essential tremor (ET). We also obtained ET information from a medical records-linkage system (family study method). In the population-based sample, the risk of ET was significantly increased for relatives of patients with onset of PD</div>
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<Abstract><AbstractText>We conducted a historical cohort study of 981 first-degree relatives of 162 patients with Parkinson's disease (PD) and of 838 first-degree relatives of 147 controls representative of the population of Olmsted County, Minnesota. In addition, we studied 2,684 first-degree relatives of 411 patients with PD referred to the Mayo Clinic. Relatives were interviewed and screened for tremor either directly or through a proxy, and those who screened positive were examined or copies of their medical records were obtained to confirm the diagnosis of essential tremor (ET). We also obtained ET information from a medical records-linkage system (family study method). In the population-based sample, the risk of ET was significantly increased for relatives of patients with onset of PD</AbstractText>
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