Movement Disorders (revue)

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Increased risk of essential tremor in first-degree relatives of patients with Parkinson's disease.

Identifieur interne : 002659 ( PubMed/Curation ); précédent : 002658; suivant : 002660

Increased risk of essential tremor in first-degree relatives of patients with Parkinson's disease.

Auteurs : Walter A. Rocca [États-Unis] ; James H. Bower ; J Eric Ahlskog ; Alexis Elbaz ; Brandon R. Grossardt ; Shannon K. Mcdonnell ; Daniel J. Schaid ; Demetrius M. Maraganore

Source :

RBID : pubmed:17546668

English descriptors

Abstract

We conducted a historical cohort study of 981 first-degree relatives of 162 patients with Parkinson's disease (PD) and of 838 first-degree relatives of 147 controls representative of the population of Olmsted County, Minnesota. In addition, we studied 2,684 first-degree relatives of 411 patients with PD referred to the Mayo Clinic. Relatives were interviewed and screened for tremor either directly or through a proxy, and those who screened positive were examined or copies of their medical records were obtained to confirm the diagnosis of essential tremor (ET). We also obtained ET information from a medical records-linkage system (family study method). In the population-based sample, the risk of ET was significantly increased for relatives of patients with onset of PD
DOI: 10.1002/mds.21584
PubMed: 17546668

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