MovDisordV3, PubMed, Curation, bibRecord, 002437

Paroxysmal dyskinesias in mice.

Identifieur interne : 002437 ( PubMed/Curation ); précédent : 002436; suivant : 002438

Paroxysmal dyskinesias in mice.

Auteurs : Thomas L. Shirley [États-Unis] ; Lekha M. Rao ; Ellen J. Hess ; H A Jinnah

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.

RBID : pubmed:17999434

English descriptors

KwdEn :
- Age Factors, Animals, Behavior, Animal, Chorea (genetics), Chorea (physiopathology), Disease Models, Animal, Mice, Mice, Inbred C57BL, Mice, Neurologic Mutants, Severity of Illness Index.
MESH :
- genetics : Chorea.
- physiopathology : Chorea.
- Age Factors, Animals, Behavior, Animal, Disease Models, Animal, Mice, Mice, Inbred C57BL, Mice, Neurologic Mutants, Severity of Illness Index.

Abstract

Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.

DOI: 10.1002/mds.21829
PubMed: 17999434

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Le document en format XML

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<author><name sortKey="Shirley, Thomas L" sort="Shirley, Thomas L" uniqKey="Shirley T" first="Thomas L" last="Shirley">Thomas L. Shirley</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea>
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<author><name sortKey="Rao, Lekha M" sort="Rao, Lekha M" uniqKey="Rao L" first="Lekha M" last="Rao">Lekha M. Rao</name>
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<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J" last="Hess">Ellen J. Hess</name>
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<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H A" last="Jinnah">H A Jinnah</name>
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<front><div type="abstract" xml:lang="en">Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders.</div>
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	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Paroxysmal dyskinesias in mice.

Paroxysmal dyskinesias in mice.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki