MovDisordV3, PubMed, Curation, bibRecord, 002429

Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death.

Identifieur interne : 002429 ( PubMed/Curation ); précédent : 002428; suivant : 002430

Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death.

Auteurs : Kambiz N. Alavian [Allemagne] ; Christian Scholz ; Horst H. Simon

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.

RBID : pubmed:18044702

English descriptors

KwdEn :
- Animals, Death, Dopamine (metabolism), Humans, Life, Mesencephalon (cytology), Neurons (metabolism), Transcription Factors (physiology).
MESH :
- chemical , metabolism : Dopamine.
- cytology : Mesencephalon.
- metabolism : Neurons.
- chemical , physiology : Transcription Factors.
- Animals, Death, Humans, Life.

Abstract

Since mesencephalic dopaminergic neurons are associated to one of the most prominent human neurodegenerative ailments, Parkinson's disease, the molecular mechanism underlying their development and adult cellular properties has been the subject of intense investigations. Throughout life, transcription factors determine the fate of this neuronal population and control essential processes such as localization in the ventral midbrain, their neurotransmitter phenotype, their target innervations and synapse formation. Studies of transcription factors, such as Nurr1, Pitx3, Engrailed-1/2, and Lmx1a/b, have not only revealed importance of these genes during development, but also roles in the long-term survival and maintenance of these neurons. In this review, we will discuss the function of these transcription factors throughout the life of mesencephalic dopaminergic neurons and their value in the study of the disease mechanism.

DOI: 10.1002/mds.21640
PubMed: 18044702

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Le document en format XML

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<author><name sortKey="Alavian, Kambiz N" sort="Alavian, Kambiz N" uniqKey="Alavian K" first="Kambiz N" last="Alavian">Kambiz N. Alavian</name>
<affiliation wicri:level="1"><nlm:affiliation>Interdisciplinary Centre for Neuroscience, Department of Neuroanatomy-Ruprecht-Karls, Universität Heidelberg, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Interdisciplinary Centre for Neuroscience, Department of Neuroanatomy-Ruprecht-Karls, Universität Heidelberg, Heidelberg</wicri:regionArea>
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<author><name sortKey="Scholz, Christian" sort="Scholz, Christian" uniqKey="Scholz C" first="Christian" last="Scholz">Christian Scholz</name>
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<author><name sortKey="Simon, Horst H" sort="Simon, Horst H" uniqKey="Simon H" first="Horst H" last="Simon">Horst H. Simon</name>
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<term>Neurons (metabolism)</term>
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<front><div type="abstract" xml:lang="en">Since mesencephalic dopaminergic neurons are associated to one of the most prominent human neurodegenerative ailments, Parkinson's disease, the molecular mechanism underlying their development and adult cellular properties has been the subject of intense investigations. Throughout life, transcription factors determine the fate of this neuronal population and control essential processes such as localization in the ventral midbrain, their neurotransmitter phenotype, their target innervations and synapse formation. Studies of transcription factors, such as Nurr1, Pitx3, Engrailed-1/2, and Lmx1a/b, have not only revealed importance of these genes during development, but also roles in the long-term survival and maintenance of these neurons. In this review, we will discuss the function of these transcription factors throughout the life of mesencephalic dopaminergic neurons and their value in the study of the disease mechanism.</div>
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<JournalIssue CitedMedium="Internet"><Volume>23</Volume>
<Issue>3</Issue>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death.</ArticleTitle>
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<Abstract><AbstractText>Since mesencephalic dopaminergic neurons are associated to one of the most prominent human neurodegenerative ailments, Parkinson's disease, the molecular mechanism underlying their development and adult cellular properties has been the subject of intense investigations. Throughout life, transcription factors determine the fate of this neuronal population and control essential processes such as localization in the ventral midbrain, their neurotransmitter phenotype, their target innervations and synapse formation. Studies of transcription factors, such as Nurr1, Pitx3, Engrailed-1/2, and Lmx1a/b, have not only revealed importance of these genes during development, but also roles in the long-term survival and maintenance of these neurons. In this review, we will discuss the function of these transcription factors throughout the life of mesencephalic dopaminergic neurons and their value in the study of the disease mechanism.</AbstractText>
<CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death.

Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki