Quantitative measures of fine motor, limb, and postural bradykinesia in very early stage, untreated Parkinson's disease.
Identifieur interne : 002224 ( PubMed/Curation ); précédent : 002223; suivant : 002225Quantitative measures of fine motor, limb, and postural bradykinesia in very early stage, untreated Parkinson's disease.
Auteurs : Mandy Miller Koop [États-Unis] ; Nicole Shivitz ; Helen Brontë-StewartSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Hypokinesia.
- physiology : Movement, Posture.
- physiopathology : Extremities.
- Aged, Case-Control Studies, Disability Evaluation, Female, Humans, Male, Middle Aged, Neurologic Examination, Severity of Illness Index.
Abstract
Few studies have characterized the motor control abnormalities of very early stage Parkinson's disease (PD), when symptoms are mild and usually unilateral. However, this group is the most targeted for potential disease-modifying therapeutics. We have validated several quantitative measures of bradykinesia with the Unified Parkinson's Disease Rating Scale motor disability score (UPDRS III) and have found these useful in studies of advanced PD. In this study, we asked if quantitative measures of finger, forearm, and postural movement velocity could detect bradykinesia in 20 patients with very early stage, untreated PD. The results revealed evidence of significant finger and forearm bradykinesia of the patient group's more affected side when compared to the nondominant side of 19 age-matched control subjects (P = 0.001 and P < 0.001, respectively). Furthermore, the patient group's forearm movement velocity on the more affected side was significantly slower than their less affected side (P = 0.005), highlighting the importance of using an outcome measure that is lateralized in studies of very early stage PD. In contrast to our previous study that revealed significant postural bradykinesia in patients with advanced PD, we did not detect postural bradykinesia in patients with very early stage, untreated PD. Based on these findings, we suggest that the use of quantitative, lateralized measures of bradykinesia would be useful in studies of very early stage, untreated PD. These measures may improve a study by: increasing efficiency and objectivity of the evaluation, decreasing cost, and decreasing the number of subjects needed for statistical significance.
DOI: 10.1002/mds.22077
PubMed: 18464283
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However, this group is the most targeted for potential disease-modifying therapeutics. We have validated several quantitative measures of bradykinesia with the Unified Parkinson's Disease Rating Scale motor disability score (UPDRS III) and have found these useful in studies of advanced PD. In this study, we asked if quantitative measures of finger, forearm, and postural movement velocity could detect bradykinesia in 20 patients with very early stage, untreated PD. The results revealed evidence of significant finger and forearm bradykinesia of the patient group's more affected side when compared to the nondominant side of 19 age-matched control subjects (P = 0.001 and P < 0.001, respectively). Furthermore, the patient group's forearm movement velocity on the more affected side was significantly slower than their less affected side (P = 0.005), highlighting the importance of using an outcome measure that is lateralized in studies of very early stage PD. In contrast to our previous study that revealed significant postural bradykinesia in patients with advanced PD, we did not detect postural bradykinesia in patients with very early stage, untreated PD. Based on these findings, we suggest that the use of quantitative, lateralized measures of bradykinesia would be useful in studies of very early stage, untreated PD. These measures may improve a study by: increasing efficiency and objectivity of the evaluation, decreasing cost, and decreasing the number of subjects needed for statistical significance.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18464283</PMID><DateCreated><Year>2008</Year><Month>08</Month><Day>05</Day></DateCreated><DateCompleted><Year>2009</Year><Month>01</Month><Day>12</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>9</Issue><PubDate><Year>2008</Year><Month>Jul</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Quantitative measures of fine motor, limb, and postural bradykinesia in very early stage, untreated Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1262-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22077</ELocationID><Abstract><AbstractText>Few studies have characterized the motor control abnormalities of very early stage Parkinson's disease (PD), when symptoms are mild and usually unilateral. However, this group is the most targeted for potential disease-modifying therapeutics. We have validated several quantitative measures of bradykinesia with the Unified Parkinson's Disease Rating Scale motor disability score (UPDRS III) and have found these useful in studies of advanced PD. In this study, we asked if quantitative measures of finger, forearm, and postural movement velocity could detect bradykinesia in 20 patients with very early stage, untreated PD. The results revealed evidence of significant finger and forearm bradykinesia of the patient group's more affected side when compared to the nondominant side of 19 age-matched control subjects (P = 0.001 and P < 0.001, respectively). Furthermore, the patient group's forearm movement velocity on the more affected side was significantly slower than their less affected side (P = 0.005), highlighting the importance of using an outcome measure that is lateralized in studies of very early stage PD. In contrast to our previous study that revealed significant postural bradykinesia in patients with advanced PD, we did not detect postural bradykinesia in patients with very early stage, untreated PD. Based on these findings, we suggest that the use of quantitative, lateralized measures of bradykinesia would be useful in studies of very early stage, untreated PD. These measures may improve a study by: increasing efficiency and objectivity of the evaluation, decreasing cost, and decreasing the number of subjects needed for statistical significance.</AbstractText><CopyrightInformation>(c) 2008 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Koop</LastName><ForeName>Mandy Miller</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Mechanical Engineering, Stanford University, Stanford, California 94305-5327, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shivitz</LastName><ForeName>Nicole</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Brontë-Stewart</LastName><ForeName>Helen</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016022">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004185">Disability Evaluation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005121">Extremities</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018476">Hypokinesia</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009068">Movement</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011187">Posture</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>5</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>1</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>5</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22077</ArticleId><ArticleId IdType="pubmed">18464283</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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