Cognitive dysfunction in Nigerians with Parkinson's disease.
Identifieur interne : 002184 ( PubMed/Curation ); précédent : 002183; suivant : 002185Cognitive dysfunction in Nigerians with Parkinson's disease.
Auteurs : Rufus O. Akinyemi [Nigeria] ; Njideka N. Okubadejo ; Joshua O. Akinyemi ; Mayowa O. Owolabi ; Lukman F. Owolabi ; Adesola OgunniyiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
Descripteurs français
- Wicri :
- geographic : Nigeria.
English descriptors
- KwdEn :
- Adult, Age Factors, Age of Onset, Aged, Aged, 80 and over, Cognition Disorders (epidemiology), Cognition Disorders (etiology), Female, Humans, Hypokinesia (etiology), Language Tests, Male, Middle Aged, Motor Activity, Neuropsychological Tests, Nigeria (epidemiology), Parkinson Disease (epidemiology), Parkinson Disease (psychology), Prefrontal Cortex (physiopathology), Tremor (etiology).
- MESH :
- geographic , epidemiology : Nigeria.
- epidemiology : Cognition Disorders, Parkinson Disease.
- etiology : Cognition Disorders, Hypokinesia, Tremor.
- physiopathology : Prefrontal Cortex.
- psychology : Parkinson Disease.
- Adult, Age Factors, Age of Onset, Aged, Aged, 80 and over, Female, Humans, Language Tests, Male, Middle Aged, Motor Activity, Neuropsychological Tests.
Abstract
Despite the original description of Parkinson's disease (PD) as a disorder in which "the senses and intellect remain uninjured," there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI'D') and selected items from the Ibadan Neuropsychological Battery (I-NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI'D' score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P < 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08-1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. Older age at disease onset is an important determinant of cognitive dysfunction in PD.
DOI: 10.1002/mds.22087
PubMed: 18546341
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Akinyemi</name></author><author><name sortKey="Owolabi, Mayowa O" sort="Owolabi, Mayowa O" uniqKey="Owolabi M" first="Mayowa O" last="Owolabi">Mayowa O. Owolabi</name></author><author><name sortKey="Owolabi, Lukman F" sort="Owolabi, Lukman F" uniqKey="Owolabi L" first="Lukman F" last="Owolabi">Lukman F. Owolabi</name></author><author><name sortKey="Ogunniyi, Adesola" sort="Ogunniyi, Adesola" uniqKey="Ogunniyi A" first="Adesola" last="Ogunniyi">Adesola Ogunniyi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22087</idno><idno type="RBID">pubmed:18546341</idno><idno type="pmid">18546341</idno><idno type="wicri:Area/PubMed/Corpus">002184</idno><idno type="wicri:Area/PubMed/Curation">002184</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cognitive dysfunction in Nigerians with Parkinson's disease.</title><author><name sortKey="Akinyemi, Rufus O" sort="Akinyemi, Rufus O" uniqKey="Akinyemi R" first="Rufus O" last="Akinyemi">Rufus O. Akinyemi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology, Department of Medicine, Federal Medical Centre, Abeokuta, Nigeria. rufusakinyemi@yahoo.com</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Division of Neurology, Department of Medicine, Federal Medical Centre, Abeokuta</wicri:regionArea></affiliation></author><author><name sortKey="Okubadejo, Njideka N" sort="Okubadejo, Njideka N" uniqKey="Okubadejo N" first="Njideka N" last="Okubadejo">Njideka N. Okubadejo</name></author><author><name sortKey="Akinyemi, Joshua O" sort="Akinyemi, Joshua O" uniqKey="Akinyemi J" first="Joshua O" last="Akinyemi">Joshua O. Akinyemi</name></author><author><name sortKey="Owolabi, Mayowa O" sort="Owolabi, Mayowa O" uniqKey="Owolabi M" first="Mayowa O" last="Owolabi">Mayowa O. Owolabi</name></author><author><name sortKey="Owolabi, Lukman F" sort="Owolabi, Lukman F" uniqKey="Owolabi L" first="Lukman F" last="Owolabi">Lukman F. Owolabi</name></author><author><name sortKey="Ogunniyi, Adesola" sort="Ogunniyi, Adesola" uniqKey="Ogunniyi A" first="Adesola" last="Ogunniyi">Adesola Ogunniyi</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Cognition Disorders (epidemiology)</term><term>Cognition Disorders (etiology)</term><term>Female</term><term>Humans</term><term>Hypokinesia (etiology)</term><term>Language Tests</term><term>Male</term><term>Middle Aged</term><term>Motor Activity</term><term>Neuropsychological Tests</term><term>Nigeria (epidemiology)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (psychology)</term><term>Prefrontal Cortex (physiopathology)</term><term>Tremor (etiology)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Nigeria</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Hypokinesia</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Language Tests</term><term>Male</term><term>Middle Aged</term><term>Motor Activity</term><term>Neuropsychological Tests</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Nigeria</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite the original description of Parkinson's disease (PD) as a disorder in which "the senses and intellect remain uninjured," there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI'D') and selected items from the Ibadan Neuropsychological Battery (I-NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI'D' score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P < 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08-1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. Older age at disease onset is an important determinant of cognitive dysfunction in PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18546341</PMID><DateCreated><Year>2008</Year><Month>08</Month><Day>05</Day></DateCreated><DateCompleted><Year>2008</Year><Month>11</Month><Day>18</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>10</Issue><PubDate><Year>2008</Year><Month>Jul</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Cognitive dysfunction in Nigerians with Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1378-83</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22087</ELocationID><Abstract><AbstractText>Despite the original description of Parkinson's disease (PD) as a disorder in which "the senses and intellect remain uninjured," there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI'D') and selected items from the Ibadan Neuropsychological Battery (I-NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI'D' score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P < 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08-1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. 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