Ultrasound treatment of cutaneous side-effects of infused apomorphine: a randomized controlled pilot study.
Identifieur interne : 001F37 ( PubMed/Curation ); précédent : 001F36; suivant : 001F38Ultrasound treatment of cutaneous side-effects of infused apomorphine: a randomized controlled pilot study.
Auteurs : Leon Poltawski [Royaume-Uni] ; Hazel Edwards ; Amy Todd ; Tim Watson ; Andrew Lees ; Cherry Ann JamesSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Apomorphine (adverse effects), Apomorphine (therapeutic use), Dopamine Agonists (adverse effects), Dopamine Agonists (therapeutic use), Drug Eruptions (etiology), Drug Eruptions (therapy), Female, Hardness, Humans, Infusions, Parenteral (adverse effects), Male, Middle Aged, Parkinson Disease (drug therapy), Pilot Projects, Sample Size, Subcutaneous Tissue (pathology), Ultrasonic Therapy.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Apomorphine, Dopamine Agonists.
- chemical , therapeutic use : Antiparkinson Agents, Apomorphine, Dopamine Agonists.
- adverse effects : Infusions, Parenteral.
- drug therapy : Parkinson Disease.
- etiology : Drug Eruptions.
- pathology : Subcutaneous Tissue.
- therapy : Drug Eruptions.
- Aged, Female, Hardness, Humans, Male, Middle Aged, Pilot Projects, Sample Size, Ultrasonic Therapy.
Abstract
Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but more substantially in the real US group. Power calculations suggest a total sample size of 30 would be required to establish statistical significance. A full-scale study of the effectiveness of therapeutic US in the treatment of apomorphine nodules is warranted.
DOI: 10.1002/mds.22316
PubMed: 19006068
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pubmed:19006068Le document en format XML
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<author><name sortKey="Poltawski, Leon" sort="Poltawski, Leon" uniqKey="Poltawski L" first="Leon" last="Poltawski">Leon Poltawski</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Physiotherapy, University of Hertfordshire, UK. l.poltawski@herts.ac.uk</nlm:affiliation>
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<author><name sortKey="Edwards, Hazel" sort="Edwards, Hazel" uniqKey="Edwards H" first="Hazel" last="Edwards">Hazel Edwards</name>
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<author><name sortKey="Todd, Amy" sort="Todd, Amy" uniqKey="Todd A" first="Amy" last="Todd">Amy Todd</name>
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<author><name sortKey="Watson, Tim" sort="Watson, Tim" uniqKey="Watson T" first="Tim" last="Watson">Tim Watson</name>
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<author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees</name>
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<author><name sortKey="James, Cherry Ann" sort="James, Cherry Ann" uniqKey="James C" first="Cherry Ann" last="James">Cherry Ann James</name>
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<term>Dopamine Agonists (adverse effects)</term>
<term>Dopamine Agonists (therapeutic use)</term>
<term>Drug Eruptions (etiology)</term>
<term>Drug Eruptions (therapy)</term>
<term>Female</term>
<term>Hardness</term>
<term>Humans</term>
<term>Infusions, Parenteral (adverse effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Pilot Projects</term>
<term>Sample Size</term>
<term>Subcutaneous Tissue (pathology)</term>
<term>Ultrasonic Therapy</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Apomorphine</term>
<term>Dopamine Agonists</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Apomorphine</term>
<term>Dopamine Agonists</term>
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<term>Female</term>
<term>Hardness</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pilot Projects</term>
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<front><div type="abstract" xml:lang="en">Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but more substantially in the real US group. Power calculations suggest a total sample size of 30 would be required to establish statistical significance. A full-scale study of the effectiveness of therapeutic US in the treatment of apomorphine nodules is warranted.</div>
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<Abstract><AbstractText>Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but more substantially in the real US group. Power calculations suggest a total sample size of 30 would be required to establish statistical significance. A full-scale study of the effectiveness of therapeutic US in the treatment of apomorphine nodules is warranted.</AbstractText>
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