Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease.
Identifieur interne : 001E84 ( PubMed/Curation ); précédent : 001E83; suivant : 001E85Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease.
Auteurs : Greg T. Sutherland [Australie] ; Gerhard A. Siebert ; Jeremy R B. Newman ; Peter A. Silburn ; Richard S. Boyle ; John D. O'Sullivan ; George D. MellickSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Carrier Proteins, Ubiquitin-Protein Ligases.
- genetics : Haplotypes, Parkinson Disease, Point Mutation.
- Aged, DNA Mutational Analysis, Female, Genotype, Humans, Male.
Abstract
Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians.
DOI: 10.1002/mds.22427
PubMed: 19117363
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pubmed:19117363Le document en format XML
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<affiliation wicri:level="1"><nlm:affiliation>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, Queensland, Australia. g.sutherland@griffith.edu.au</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, Queensland</wicri:regionArea>
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<author><name sortKey="Siebert, Gerhard A" sort="Siebert, Gerhard A" uniqKey="Siebert G" first="Gerhard A" last="Siebert">Gerhard A. Siebert</name>
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<author><name sortKey="Newman, Jeremy R B" sort="Newman, Jeremy R B" uniqKey="Newman J" first="Jeremy R B" last="Newman">Jeremy R B. Newman</name>
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<author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A" last="Silburn">Peter A. Silburn</name>
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<author><name sortKey="Boyle, Richard S" sort="Boyle, Richard S" uniqKey="Boyle R" first="Richard S" last="Boyle">Richard S. Boyle</name>
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<author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D" last="O'Sullivan">John D. O'Sullivan</name>
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<term>Humans</term>
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<term>Parkinson Disease (genetics)</term>
<term>Point Mutation (genetics)</term>
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<front><div type="abstract" xml:lang="en">Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians.</div>
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<Abstract><AbstractText>Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians.</AbstractText>
<CopyrightInformation>(c) 2008 Movement Disorder Society.</CopyrightInformation>
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