MovDisordV3, PubMed, Curation, bibRecord, 001D75

Immunopathogenic mechanisms in tourette syndrome: A critical review.

Identifieur interne : 001D75 ( PubMed/Curation ); précédent : 001D74; suivant : 001D76

Immunopathogenic mechanisms in tourette syndrome: A critical review.

Auteurs : Davide Martino [Italie] ; Russell C. Dale ; Donald L. Gilbert ; Gavin Giovannoni ; James F. Leckman

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.

RBID : pubmed:19353683

English descriptors

KwdEn :
- Autoantibodies (metabolism), Environment, Gene Expression Regulation (immunology), Humans, Immune System (cytology), Immune System (pathology), Immune System (physiopathology), Models, Immunological, Stress, Psychological (immunology), Tourette Syndrome (genetics), Tourette Syndrome (immunology), Tourette Syndrome (pathology).
MESH :
- chemical , metabolism : Autoantibodies.
- cytology : Immune System.
- genetics : Tourette Syndrome.
- immunology : Gene Expression Regulation, Stress, Psychological, Tourette Syndrome.
- pathology : Immune System, Tourette Syndrome.
- physiopathology : Immune System.
- Environment, Humans, Models, Immunological.

Abstract

Tourette syndrome (TS) has a multifactorial etiology, in which genetic, environmental, immunological and hormonal factors interact to establish vulnerability. This review: (i) summarizes research exploring the exposure of TS patients to immune-activating environmental factors, and (ii) focuses on recent findings supporting a role of the innate and adaptive immune systems in the pathogenesis of TS and related disorders. A higher exposure prior to disease onset to group A beta-haemolytic streptococcal (GABHS) infections in children with tics and obsessive-compulsive (OC) symptoms has been documented, although their influence upon the course of disease remains uncertain. Increased activation of immune responses in TS is suggested by changes in gene expression profiles of peripheral immune cells, relative frequency of lymphocyte subpopulations, and synthesis of immune effector molecules. Increased activity of cell-mediated mechanisms is suggested by the increased expression of genes controlling natural killer and cytotoxic T cells, increased plasma levels of some pro-inflammatory cytokines which correlate with disease severity, and increased synthesis of antineuronal antibodies. Important methodological differences might account for some inconsistency among results of studies addressing autoantibodies in TS. Finally, a general predisposition to autoimmune responses in TS patients is indicated by the reduced frequency of regulatory T cells, which induce tolerance towards self-antigens. Although the pathogenic role of immune activation in TS has not been definitively proven, a pathophysiological model is proposed to explain the possible effect of immunity upon dopamine transmission regulation and the generation of tics.

DOI: 10.1002/mds.22504
PubMed: 19353683

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<front><div type="abstract" xml:lang="en">Tourette syndrome (TS) has a multifactorial etiology, in which genetic, environmental, immunological and hormonal factors interact to establish vulnerability. This review: (i) summarizes research exploring the exposure of TS patients to immune-activating environmental factors, and (ii) focuses on recent findings supporting a role of the innate and adaptive immune systems in the pathogenesis of TS and related disorders. A higher exposure prior to disease onset to group A beta-haemolytic streptococcal (GABHS) infections in children with tics and obsessive-compulsive (OC) symptoms has been documented, although their influence upon the course of disease remains uncertain. Increased activation of immune responses in TS is suggested by changes in gene expression profiles of peripheral immune cells, relative frequency of lymphocyte subpopulations, and synthesis of immune effector molecules. Increased activity of cell-mediated mechanisms is suggested by the increased expression of genes controlling natural killer and cytotoxic T cells, increased plasma levels of some pro-inflammatory cytokines which correlate with disease severity, and increased synthesis of antineuronal antibodies. Important methodological differences might account for some inconsistency among results of studies addressing autoantibodies in TS. Finally, a general predisposition to autoimmune responses in TS patients is indicated by the reduced frequency of regulatory T cells, which induce tolerance towards self-antigens. Although the pathogenic role of immune activation in TS has not been definitively proven, a pathophysiological model is proposed to explain the possible effect of immunity upon dopamine transmission regulation and the generation of tics.</div>
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<Abstract><AbstractText>Tourette syndrome (TS) has a multifactorial etiology, in which genetic, environmental, immunological and hormonal factors interact to establish vulnerability. This review: (i) summarizes research exploring the exposure of TS patients to immune-activating environmental factors, and (ii) focuses on recent findings supporting a role of the innate and adaptive immune systems in the pathogenesis of TS and related disorders. A higher exposure prior to disease onset to group A beta-haemolytic streptococcal (GABHS) infections in children with tics and obsessive-compulsive (OC) symptoms has been documented, although their influence upon the course of disease remains uncertain. Increased activation of immune responses in TS is suggested by changes in gene expression profiles of peripheral immune cells, relative frequency of lymphocyte subpopulations, and synthesis of immune effector molecules. Increased activity of cell-mediated mechanisms is suggested by the increased expression of genes controlling natural killer and cytotoxic T cells, increased plasma levels of some pro-inflammatory cytokines which correlate with disease severity, and increased synthesis of antineuronal antibodies. Important methodological differences might account for some inconsistency among results of studies addressing autoantibodies in TS. Finally, a general predisposition to autoimmune responses in TS patients is indicated by the reduced frequency of regulatory T cells, which induce tolerance towards self-antigens. Although the pathogenic role of immune activation in TS has not been definitively proven, a pathophysiological model is proposed to explain the possible effect of immunity upon dopamine transmission regulation and the generation of tics.</AbstractText>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2007 Feb 1;61(3):273-8</RefSource>
<PMID Version="1">16996487</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2007 Feb 1;61(3):279-84</RefSource>
<PMID Version="1">17126304</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Child Psychol Psychiatry. 2007 Feb;48(2):157-66</RefSource>
<PMID Version="1">17300554</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur Child Adolesc Psychiatry. 2007 Jun;16 Suppl 1:71-7</RefSource>
<PMID Version="1">17665285</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Am Acad Child Adolesc Psychiatry. 2007 Aug;46(8):947-68</RefSource>
<PMID Version="1">17667475</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 5;144B(7):958-63</RefSource>
<PMID Version="1">17503477</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2007 Oct 18;449(7164):819-26</RefSource>
<PMID Version="1">17943118</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Psychiatr Res. 2008 Jan;42(1):64-8</RefSource>
<PMID Version="1">17113107</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2008 Jan 10;186(1):84-90</RefSource>
<PMID Version="1">17850895</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Pediatr. 2007 Dec;151(6):679-83</RefSource>
<PMID Version="1">18035153</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2008 Jan;9(1):46-56</RefSource>
<PMID Version="1">18073775</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2000 Feb;157(2):281-3</RefSource>
<PMID Version="1">10671403</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2000 Apr;47(4):504-10</RefSource>
<PMID Version="1">10762162</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trends Neurosci. 2000 Jul;23(7):317-27</RefSource>
<PMID Version="1">10856942</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Microbiol Rev. 2000 Jul;13(3):470-511</RefSource>
<PMID Version="1">10885988</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroimmunol. 2000 Nov 1;111(1-2):195-202</RefSource>
<PMID Version="1">11063838</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2000 Dec;182(6):1712-21</RefSource>
<PMID Version="1">11069244</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2000 Dec;157(12):2036-8</RefSource>
<PMID Version="1">11097972</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Pediatr. 2001 Jan;138(1):71-5</RefSource>
<PMID Version="1">11148515</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroimmunol. 2001 Sep 3;119(1):106-13</RefSource>
<PMID Version="1">11525807</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2001 Nov 2;276(44):40411-6</RefSource>
<PMID Version="1">11502746</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2001 Oct 15;50(8):566-77</RefSource>
<PMID Version="1">11690591</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2002 Jan;109(1):131-40</RefSource>
<PMID Version="1">11781358</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Gen Psychiatry. 2002 Mar;59(3):215-22</RefSource>
<PMID Version="1">11879158</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2002 Apr;159(4):657-60</RefSource>
<PMID Version="1">11925307</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Pediatr Adolesc Med. 2002 Apr;156(4):356-61</RefSource>
<PMID Version="1">11929370</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2002 Jul 23;59(2):227-31</RefSource>
<PMID Version="1">12136062</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2002 Aug;159(8):1329-36</RefSource>
<PMID Version="1">12153825</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2002 Nov 16;360(9345):1577-86</RefSource>
<PMID Version="1">12443611</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2003 Feb;3(2):133-46</RefSource>
<PMID Version="1">12563297</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroimmunol. 2003 Mar;136(1-2):154-61</RefSource>
<PMID Version="1">12620655</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Horm Res. 2003;59(4):161-79</RefSource>
<PMID Version="1">12649570</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2003 May;74(5):602-7</RefSource>
<PMID Version="1">12700302</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pediatr Neurol. 2003 Feb;28(2):119-25</RefSource>
<PMID Version="1">12699862</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2003 Jul;9(7):914-20</RefSource>
<PMID Version="1">12819778</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Med Chem. 2003 Aug;10(16):1581-91</RefSource>
<PMID Version="1">12871129</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2003 Aug 12;61(3):310-5</RefSource>
<PMID Version="1">12913189</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2003 Sep;160(9):1554-65</RefSource>
<PMID Version="1">12944327</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Autoimmun. 2003 Nov;21(3):273-6</RefSource>
<PMID Version="1">14599852</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2003 Dec;18(12):1554-6</RefSource>
<PMID Version="1">14673900</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2004 Jan 1;55(1):61-8</RefSource>
<PMID Version="1">14706426</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2004 Feb 18;24(7):1780-91</RefSource>
<PMID Version="1">14973249</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pediatr Neurol. 2004 Feb;30(2):107-10</RefSource>
<PMID Version="1">14984902</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2004 Mar 17;24(11):2825-31</RefSource>
<PMID Version="1">15028776</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Semin Immunol. 2004 Apr;16(2):81-8</RefSource>
<PMID Version="1">15036231</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2004 Apr;161(4):631-6</RefSource>
<PMID Version="1">15056508</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pediatrics. 2004 Apr;113(4):883-6</RefSource>
<PMID Version="1">15060240</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pediatrics. 2004 Apr;113(4):907-11</RefSource>
<PMID Version="1">15060242</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2004 Apr;19(4):390-6</RefSource>
<PMID Version="1">15077236</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Child Neurol. 2008 Mar;23(3):338-40</RefSource>
<PMID Version="1">18079308</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Dev Immunol. 2007;2007:89195</RefSource>
<PMID Version="1">18317534</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2008 May 15;23(7):958-63</RefSource>
<PMID Version="1">18383532</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pediatrics. 2008 Jun;121(6):1188-97</RefSource>
<PMID Version="1">18519489</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pediatrics. 2008 Jun;121(6):1198-205</RefSource>
<PMID Version="1">18519490</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2008 Jul;79(7):820-2</RefSource>
<PMID Version="1">18303105</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Neurol. 2008 Jul;15(7):749-53</RefSource>
<PMID Version="1">18484991</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Psychoneuroendocrinology. 2008 Jul;33(6):810-20</RefSource>
<PMID Version="1">18487023</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Psychiatr Res. 2008 Nov;43(1):24-9</RefSource>
<PMID Version="1">18329046</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Psychiatr Res. 2009 Jan;43(3):319-30</RefSource>
<PMID Version="1">18485367</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Am Acad Child Adolesc Psychiatry. 2008 Oct;47(10):1166-72</RefSource>
<PMID Version="1">18724258</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2004 Apr;19(4):406-15</RefSource>
<PMID Version="1">15077238</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Psychiatry. 2004 Mar;65(3):426-31</RefSource>
<PMID Version="1">15096084</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Psychiatry. 2004 Apr;65(4):537-42</RefSource>
<PMID Version="1">15119917</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2004 May 15;172(10):6435-43</RefSource>
<PMID Version="1">15128835</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pediatrics. 2004 Jun;113(6):e578-85</RefSource>
<PMID Version="1">15173540</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Psychoneuroendocrinology. 2004 Aug;29(7):945-52</RefSource>
<PMID Version="1">15177711</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Dis Child. 2004 Jul;89(7):611-4</RefSource>
<PMID Version="1">15210488</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2004 Jul 7;24(27):6133-43</RefSource>
<PMID Version="1">15240805</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2004 Aug;161(8):1501-2</RefSource>
<PMID Version="1">15285987</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Pediatr Adolesc Med. 2004 Sep;158(9):848-56</RefSource>
<PMID Version="1">15351749</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1976 Oct 1;144(4):1094-110</RefSource>
<PMID Version="1">789810</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 1977 May;59(5):922-32</RefSource>
<PMID Version="1">140183</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Neurosci. 1988 Apr;39(3-4):225-7</RefSource>
<PMID Version="1">3165969</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 1989 Feb;146(2):246-9</RefSource>
<PMID Version="1">2912267</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trends Neurosci. 1989 Oct;12(10):366-75</RefSource>
<PMID Version="1">2479133</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Psychiatry. 1990 Aug;51 Suppl:36-43; discussion 55-8</RefSource>
<PMID Version="1">2199433</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Psychiatry Res. 1990 Jul;33(1):73-81</RefSource>
<PMID Version="1">2217660</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pediatrics. 1993 Jul;92(1):39-43</RefSource>
<PMID Version="1">8516083</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 1994 Jul 1;36(1):35-43</RefSource>
<PMID Version="1">8080901</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Dev Behav Pediatr. 1994 Dec;15(6):421-5</RefSource>
<PMID Version="1">7884013</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Am Acad Child Adolesc Psychiatry. 1995 Nov;34(11):1495-503</RefSource>
<PMID Version="1">8543518</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 1995 Dec;45(12):2199-202</RefSource>
<PMID Version="1">8848193</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 1996 May 1;39(9):776-83</RefSource>
<PMID Version="1">8731518</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Am Acad Child Adolesc Psychiatry. 1996 Mar;35(3):343-51</RefSource>
<PMID Version="1">8714323</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1997 Sep 15;159(6):2994-9</RefSource>
<PMID Version="1">9300724</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 1997 Dec 1;42(11):976-81</RefSource>
<PMID Version="1">9386848</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 1998 Feb;155(2):264-71</RefSource>
<PMID Version="1">9464208</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 1998 Jun;50(6):1618-24</RefSource>
<PMID Version="1">9633702</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuropsychobiology. 1998;37(4):182-5</RefSource>
<PMID Version="1">9648125</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 1999 May 15;19(10):3801-8</RefSource>
<PMID Version="1">10234012</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 1999 Sep 15;46(6):775-80</RefSource>
<PMID Version="1">10494445</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 1999 Oct 2;354(9185):1153-8</RefSource>
<PMID Version="1">10513708</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Psychiatry Res. 2004 Dec 15;129(2):119-25</RefSource>
<PMID Version="1">15590039</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain Dev. 2005 Jan;27(1):62-5</RefSource>
<PMID Version="1">15626544</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2005 Feb;62(2):210-5</RefSource>
<PMID Version="1">15710849</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2005 Mar 15;57(6):667-73</RefSource>
<PMID Version="1">15780855</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5150-5</RefSource>
<PMID Version="1">15788534</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroimmunol. 2005 Jun;163(1-2):8-14</RefSource>
<PMID Version="1">15885303</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Child Adolesc Psychopharmacol. 2005 Apr;15(2):285-92</RefSource>
<PMID Version="1">15910212</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Child Neurol. 2005 May;20(5):424-9</RefSource>
<PMID Version="1">15968928</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurol Sci. 2005 Jul 15;234(1-2):79-85</RefSource>
<PMID Version="1">15941572</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pediatrics. 2005 Jul;116(1):56-60</RefSource>
<PMID Version="1">15995031</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2005 Jul;20(7):843-5</RefSource>
<PMID Version="1">15747354</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroimmunol. 2005 Dec;169(1-2):161-71</RefSource>
<PMID Version="1">16150496</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2005 Dec 13;65(11):1701-7</RefSource>
<PMID Version="1">16207842</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biomed Sci. 2006 Jan;13(1):101-12</RefSource>
<PMID Version="1">16215701</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Autoimmunity. 2006 Feb;39(1):21-9</RefSource>
<PMID Version="1">16455579</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroimmunol. 2006 Mar;172(1-2):187-97</RefSource>
<PMID Version="1">16356555</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>NeuroRx. 2006 Apr;3(2):192-206</RefSource>
<PMID Version="1">16554257</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Child Neurol. 2006 Sep;21(9):747-53</RefSource>
<PMID Version="1">16970879</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroimmunol. 2006 Oct;179(1-2):173-9</RefSource>
<PMID Version="1">16875742</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2006 Oct 15;60(8):803-11</RefSource>
<PMID Version="1">16814258</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroimmunol. 2006 Dec;181(1-2):165-76</RefSource>
<PMID Version="1">17011640</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Immunopathogenic mechanisms in tourette syndrome: A critical review.

Immunopathogenic mechanisms in tourette syndrome: A critical review.

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