Postural tremor in X-linked spinal and bulbar muscular atrophy.
Identifieur interne : 001B63 ( PubMed/Curation ); précédent : 001B62; suivant : 001B64Postural tremor in X-linked spinal and bulbar muscular atrophy.
Auteurs : Ritsuko Hanajima [Japon] ; Yasuo Terao ; Setsu Nakatani-Enomoto ; Masashi Hamada ; Akihiro Yugeta ; Hideyuki Matsumoto ; Tomotaka Yamamoto ; Shoji Tsuji ; Yoshikazu UgawaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Adult, Age of Onset, DNA Repeat Expansion, Electromyography, Fourier Analysis, Genes, X-Linked (genetics), Humans, Male, Median Nerve (physiopathology), Middle Aged, Muscular Disorders, Atrophic (complications), Muscular Disorders, Atrophic (genetics), Muscular Disorders, Atrophic (physiopathology), Posture, Tremor (etiology), Tremor (physiopathology), Ulnar Nerve (physiopathology), Upper Extremity (physiopathology).
- MESH :
- complications : Muscular Disorders, Atrophic.
- etiology : Tremor.
- genetics : Genes, X-Linked, Muscular Disorders, Atrophic.
- physiopathology : Median Nerve, Muscular Disorders, Atrophic, Tremor, Ulnar Nerve, Upper Extremity.
- Adult, Age of Onset, DNA Repeat Expansion, Electromyography, Fourier Analysis, Humans, Male, Middle Aged, Posture.
Abstract
Postural tremor is a common initial symptom in spinal and bulbar muscular atrophy (SBMA), but its pathophysiological mechanisms remain to be studied. This study was undertaken to examine the physiological mechanisms underlying postural tremor in SBMA. For eight patients (36-63 years old) with genetically confirmed SBMA, we recorded surface electromyograms (EMGs) from the forearm muscles and hand movements with an accelerometer (ACC) while maintaining a posture with and without a weight load. We then analyzed their power spectra and coherence. The peak tremor frequency was 6-9 Hz in seven patients and 2-3 Hz in one patient. Oscillatory movements were associated with EMG activity in five patients, but not in three patients. Weight loads and postural changes affected the tremor frequency in all patients. Tremor was classified as "reflex tremor" in five patients and "mechanical tremor" in three patients. These results suggest that peripheral factors play important roles in tremor genesis in SBMA, although its clinical features resemble essential tremor. Subclinical sensory disturbance or a decrease of motor unit numbers might be candidates for such peripheral factors contributing to tremor genesis in SBMA.
DOI: 10.1002/mds.22566
PubMed: 19746452
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first="Masashi" last="Hamada">Masashi Hamada</name></author><author><name sortKey="Yugeta, Akihiro" sort="Yugeta, Akihiro" uniqKey="Yugeta A" first="Akihiro" last="Yugeta">Akihiro Yugeta</name></author><author><name sortKey="Matsumoto, Hideyuki" sort="Matsumoto, Hideyuki" uniqKey="Matsumoto H" first="Hideyuki" last="Matsumoto">Hideyuki Matsumoto</name></author><author><name sortKey="Yamamoto, Tomotaka" sort="Yamamoto, Tomotaka" uniqKey="Yamamoto T" first="Tomotaka" last="Yamamoto">Tomotaka Yamamoto</name></author><author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name></author><author><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22566</idno><idno type="RBID">pubmed:19746452</idno><idno 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last="Nakatani-Enomoto">Setsu Nakatani-Enomoto</name></author><author><name sortKey="Hamada, Masashi" sort="Hamada, Masashi" uniqKey="Hamada M" first="Masashi" last="Hamada">Masashi Hamada</name></author><author><name sortKey="Yugeta, Akihiro" sort="Yugeta, Akihiro" uniqKey="Yugeta A" first="Akihiro" last="Yugeta">Akihiro Yugeta</name></author><author><name sortKey="Matsumoto, Hideyuki" sort="Matsumoto, Hideyuki" uniqKey="Matsumoto H" first="Hideyuki" last="Matsumoto">Hideyuki Matsumoto</name></author><author><name sortKey="Yamamoto, Tomotaka" sort="Yamamoto, Tomotaka" uniqKey="Yamamoto T" first="Tomotaka" last="Yamamoto">Tomotaka Yamamoto</name></author><author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name></author><author><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>DNA Repeat Expansion</term><term>Electromyography</term><term>Fourier Analysis</term><term>Genes, X-Linked (genetics)</term><term>Humans</term><term>Male</term><term>Median Nerve (physiopathology)</term><term>Middle Aged</term><term>Muscular Disorders, Atrophic (complications)</term><term>Muscular Disorders, Atrophic (genetics)</term><term>Muscular Disorders, Atrophic (physiopathology)</term><term>Posture</term><term>Tremor (etiology)</term><term>Tremor (physiopathology)</term><term>Ulnar Nerve (physiopathology)</term><term>Upper Extremity (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Muscular Disorders, Atrophic</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genes, X-Linked</term><term>Muscular Disorders, Atrophic</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Median Nerve</term><term>Muscular Disorders, Atrophic</term><term>Tremor</term><term>Ulnar Nerve</term><term>Upper Extremity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>DNA Repeat Expansion</term><term>Electromyography</term><term>Fourier Analysis</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Posture</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Postural tremor is a common initial symptom in spinal and bulbar muscular atrophy (SBMA), but its pathophysiological mechanisms remain to be studied. This study was undertaken to examine the physiological mechanisms underlying postural tremor in SBMA. For eight patients (36-63 years old) with genetically confirmed SBMA, we recorded surface electromyograms (EMGs) from the forearm muscles and hand movements with an accelerometer (ACC) while maintaining a posture with and without a weight load. We then analyzed their power spectra and coherence. The peak tremor frequency was 6-9 Hz in seven patients and 2-3 Hz in one patient. Oscillatory movements were associated with EMG activity in five patients, but not in three patients. Weight loads and postural changes affected the tremor frequency in all patients. Tremor was classified as "reflex tremor" in five patients and "mechanical tremor" in three patients. These results suggest that peripheral factors play important roles in tremor genesis in SBMA, although its clinical features resemble essential tremor. Subclinical sensory disturbance or a decrease of motor unit numbers might be candidates for such peripheral factors contributing to tremor genesis in SBMA.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19746452</PMID><DateCreated><Year>2009</Year><Month>11</Month><Day>05</Day></DateCreated><DateCompleted><Year>2010</Year><Month>01</Month><Day>12</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>14</Issue><PubDate><Year>2009</Year><Month>Oct</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Postural tremor in X-linked spinal and bulbar muscular atrophy.</ArticleTitle><Pagination><MedlinePgn>2063-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22566</ELocationID><Abstract><AbstractText>Postural tremor is a common initial symptom in spinal and bulbar muscular atrophy (SBMA), but its pathophysiological mechanisms remain to be studied. This study was undertaken to examine the physiological mechanisms underlying postural tremor in SBMA. For eight patients (36-63 years old) with genetically confirmed SBMA, we recorded surface electromyograms (EMGs) from the forearm muscles and hand movements with an accelerometer (ACC) while maintaining a posture with and without a weight load. We then analyzed their power spectra and coherence. The peak tremor frequency was 6-9 Hz in seven patients and 2-3 Hz in one patient. Oscillatory movements were associated with EMG activity in five patients, but not in three patients. Weight loads and postural changes affected the tremor frequency in all patients. Tremor was classified as "reflex tremor" in five patients and "mechanical tremor" in three patients. These results suggest that peripheral factors play important roles in tremor genesis in SBMA, although its clinical features resemble essential tremor. Subclinical sensory disturbance or a decrease of motor unit numbers might be candidates for such peripheral factors contributing to tremor genesis in SBMA.</AbstractText><CopyrightInformation>(c) 2009 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hanajima</LastName><ForeName>Ritsuko</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, The University of Tokyo Hospital, Tokyo, Japan. hanajima-tky@umin.ac.jp</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Terao</LastName><ForeName>Yasuo</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Nakatani-Enomoto</LastName><ForeName>Setsu</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Hamada</LastName><ForeName>Masashi</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Yugeta</LastName><ForeName>Akihiro</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Matsumoto</LastName><ForeName>Hideyuki</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Yamamoto</LastName><ForeName>Tomotaka</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Tsuji</LastName><ForeName>Shoji</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Ugawa</LastName><ForeName>Yoshikazu</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017668">Age of Onset</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D042622">DNA Repeat Expansion</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005583">Fourier Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D050172">Genes, X-Linked</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008475">Median Nerve</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020966">Muscular Disorders, Atrophic</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011187">Posture</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014202">Tremor</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014459">Ulnar Nerve</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D034941">Upper Extremity</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>1</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22566</ArticleId><ArticleId IdType="pubmed">19746452</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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