Imitation in patients with Gilles de la Tourette syndrome--a behavioral study.
Identifieur interne : 001816 ( PubMed/Curation ); précédent : 001815; suivant : 001817Imitation in patients with Gilles de la Tourette syndrome--a behavioral study.
Auteurs : Melanie Jonas [Allemagne] ; Götz Thomalla ; Katja Biermann-Ruben ; Hartwig Roman Siebner ; Kirsten Müller-Vahl ; Tobias B Umer ; Christian Gerloff ; Alfons Schnitzler ; Michael Orth ; Alexander MünchauSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- physiology : Imitative Behavior, Movement, Psychomotor Performance, Reaction Time.
- physiopathology : Tourette Syndrome.
- Adult, Analysis of Variance, Female, Humans, Male, Middle Aged, Severity of Illness Index, Statistics as Topic, Young Adult.
Abstract
Echophenomena in Gilles de la Tourette syndrome (GTS) may relate to deficient processing of observed biological movements. This would be reflected in altered effects of movement observation on motor responses in these patients. We studied reaction times in 11 unmedicated GTS patients without psychiatric comorbidity and healthy subjects. In experiment 1, participants imitated single biological finger movement stimuli or nonbiological dot movement stimuli immediately. In experiment 2, participants responded to a tone while viewing biological or nonbiological movement stimuli that were either compatible (identical) or incompatible (different) with their response. In experiment 1, both patients and healthy subjects responded faster to single biological than to nonbiological stimuli. In experiment 2, biological stimuli caused a larger compatibility-effect in responses than nonbiological stimuli in both groups, provided stimulus presentation and response initiation coincided. Healthy subjects responded faster to compatible biological than nonbiological stimuli. In contrast, GTS patients responded slower to incompatible biological than nonbiological stimuli. Patients' mean reaction time in experiment 2 correlated with phonic tic-frequency. Motor facilitation by observing biological movements appears to rely on concomitance of stimuli and responses in GTS patients and healthy individuals. Differing behavioral effects of movement observation in GTS might reflect altered activation of an action observation-execution matching system. To avoid unwanted movements GTS patients probably have to inhibit motor activation induced by observed movement automatically. Thus, movement stimuli may facilitate similar motor responses less but interfere more with different responses in these patients.
DOI: 10.1002/mds.22994
PubMed: 20535824
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sort="Siebner, Hartwig Roman" uniqKey="Siebner H" first="Hartwig Roman" last="Siebner">Hartwig Roman Siebner</name></author><author><name sortKey="Muller Vahl, Kirsten" sort="Muller Vahl, Kirsten" uniqKey="Muller Vahl K" first="Kirsten" last="Müller-Vahl">Kirsten Müller-Vahl</name></author><author><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name></author><author><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name></author><author><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.22994</idno><idno type="RBID">pubmed:20535824</idno><idno type="pmid">20535824</idno><idno type="wicri:Area/PubMed/Corpus">001816</idno><idno type="wicri:Area/PubMed/Curation">001816</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Imitation in patients with Gilles de la Tourette syndrome--a behavioral study.</title><author><name sortKey="Jonas, Melanie" sort="Jonas, Melanie" uniqKey="Jonas M" first="Melanie" last="Jonas">Melanie Jonas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. m.jonas@uke.uni-hamburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name></author><author><name sortKey="Biermann Ruben, Katja" sort="Biermann Ruben, Katja" uniqKey="Biermann Ruben K" first="Katja" last="Biermann-Ruben">Katja Biermann-Ruben</name></author><author><name sortKey="Siebner, Hartwig Roman" sort="Siebner, Hartwig Roman" uniqKey="Siebner H" first="Hartwig Roman" last="Siebner">Hartwig Roman Siebner</name></author><author><name sortKey="Muller Vahl, Kirsten" sort="Muller Vahl, Kirsten" uniqKey="Muller Vahl K" first="Kirsten" last="Müller-Vahl">Kirsten Müller-Vahl</name></author><author><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name></author><author><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name></author><author><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Imitative Behavior (physiology)</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Psychomotor Performance (physiology)</term><term>Reaction Time (physiology)</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Tourette Syndrome (physiopathology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Imitative Behavior</term><term>Movement</term><term>Psychomotor Performance</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Echophenomena in Gilles de la Tourette syndrome (GTS) may relate to deficient processing of observed biological movements. This would be reflected in altered effects of movement observation on motor responses in these patients. We studied reaction times in 11 unmedicated GTS patients without psychiatric comorbidity and healthy subjects. In experiment 1, participants imitated single biological finger movement stimuli or nonbiological dot movement stimuli immediately. In experiment 2, participants responded to a tone while viewing biological or nonbiological movement stimuli that were either compatible (identical) or incompatible (different) with their response. In experiment 1, both patients and healthy subjects responded faster to single biological than to nonbiological stimuli. In experiment 2, biological stimuli caused a larger compatibility-effect in responses than nonbiological stimuli in both groups, provided stimulus presentation and response initiation coincided. Healthy subjects responded faster to compatible biological than nonbiological stimuli. In contrast, GTS patients responded slower to incompatible biological than nonbiological stimuli. Patients' mean reaction time in experiment 2 correlated with phonic tic-frequency. Motor facilitation by observing biological movements appears to rely on concomitance of stimuli and responses in GTS patients and healthy individuals. Differing behavioral effects of movement observation in GTS might reflect altered activation of an action observation-execution matching system. To avoid unwanted movements GTS patients probably have to inhibit motor activation induced by observed movement automatically. Thus, movement stimuli may facilitate similar motor responses less but interfere more with different responses in these patients.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20535824</PMID><DateCreated><Year>2010</Year><Month>06</Month><Day>21</Day></DateCreated><DateCompleted><Year>2010</Year><Month>09</Month><Day>20</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>8</Issue><PubDate><Year>2010</Year><Month>Jun</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Imitation in patients with Gilles de la Tourette syndrome--a behavioral study.</ArticleTitle><Pagination><MedlinePgn>991-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22994</ELocationID><Abstract><AbstractText>Echophenomena in Gilles de la Tourette syndrome (GTS) may relate to deficient processing of observed biological movements. This would be reflected in altered effects of movement observation on motor responses in these patients. We studied reaction times in 11 unmedicated GTS patients without psychiatric comorbidity and healthy subjects. In experiment 1, participants imitated single biological finger movement stimuli or nonbiological dot movement stimuli immediately. In experiment 2, participants responded to a tone while viewing biological or nonbiological movement stimuli that were either compatible (identical) or incompatible (different) with their response. In experiment 1, both patients and healthy subjects responded faster to single biological than to nonbiological stimuli. In experiment 2, biological stimuli caused a larger compatibility-effect in responses than nonbiological stimuli in both groups, provided stimulus presentation and response initiation coincided. Healthy subjects responded faster to compatible biological than nonbiological stimuli. In contrast, GTS patients responded slower to incompatible biological than nonbiological stimuli. Patients' mean reaction time in experiment 2 correlated with phonic tic-frequency. Motor facilitation by observing biological movements appears to rely on concomitance of stimuli and responses in GTS patients and healthy individuals. Differing behavioral effects of movement observation in GTS might reflect altered activation of an action observation-execution matching system. To avoid unwanted movements GTS patients probably have to inhibit motor activation induced by observed movement automatically. Thus, movement stimuli may facilitate similar motor responses less but interfere more with different responses in these patients.</AbstractText><CopyrightInformation>(c) 2010 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jonas</LastName><ForeName>Melanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. m.jonas@uke.uni-hamburg.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomalla</LastName><ForeName>Götz</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Biermann-Ruben</LastName><ForeName>Katja</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Siebner</LastName><ForeName>Hartwig Roman</ForeName><Initials>HR</Initials></Author><Author ValidYN="Y"><LastName>Müller-Vahl</LastName><ForeName>Kirsten</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Bäumer</LastName><ForeName>Tobias</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Gerloff</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Schnitzler</LastName><ForeName>Alfons</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Orth</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Münchau</LastName><ForeName>Alexander</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000704">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007100">Imitative Behavior</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009068">Movement</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011597">Psychomotor Performance</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013223">Statistics as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005879">Tourette Syndrome</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D055815">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>6</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>6</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>9</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22994</ArticleId><ArticleId IdType="pubmed">20535824</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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