Major life events and risk of Parkinson's disease.
Identifieur interne : 001774 ( PubMed/Curation ); précédent : 001773; suivant : 001775Major life events and risk of Parkinson's disease.
Auteurs : Naja Hulvej Rod [Danemark] ; Johnni Hansen ; Eva Schernhammer ; Beate RitzSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
Descripteurs français
- Wicri :
- geographic : Danemark.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Denmark.
- epidemiology : Parkinson Disease.
- psychology : Parkinson Disease.
- Adult, Age Factors, Aged, Aged, 80 and over, Female, Humans, Life Change Events, Male, Middle Aged, Retrospective Studies, Risk Factors, Sex Factors.
Abstract
Major life events such as divorce, death of a spouse or a child, or long-term unemployment are stressful to most people and animal models have suggested a link between stress and onset of parkinsonian symptoms. In a large case-control study based on nationwide registries, we aim to address whether major life events are risk factors for Parkinson's disease. Between 1986 and 2006, we identified 13,695 patients with a (PD) primary diagnosis of PD in the Danish National Hospital Register. Each case was frequency matched by age and gender to five population controls. Information on major life events before onset of PD was ascertained from national registries. Among men, number of life events was associated with risk of Parkinson's disease in an inverse dose-response manner (P < 0.0001). Compared to no events, three or more events were associated with a 42% lower risk of PD (OR = 0.58; 95 % CI: 0.34-0.99). Life events were not associated with PD in women. In contrast, a higher risk of PD was observed among women who had never been married (1.16; 1.04-1.29) and among men (1.47; 1.18-1.82) and women (1.30; 1.05-1.61) who have never been employees. The lower risk of Parkinson's disease among men who had experienced life events was unexpected but might suggest a general "risk avoidance behavior" in Parkinson's patients.
DOI: 10.1002/mds.22850
PubMed: 20602449
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001774
Links to Exploration step
pubmed:20602449Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Major life events and risk of Parkinson's disease.</title>
<author><name sortKey="Rod, Naja Hulvej" sort="Rod, Naja Hulvej" uniqKey="Rod N" first="Naja Hulvej" last="Rod">Naja Hulvej Rod</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Public Health, University of Copenhagen, Department of Social Medicine, Copenhagen, Denmark. n.rod@pubhealth.ku.dk</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Institute of Public Health, University of Copenhagen, Department of Social Medicine, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hansen, Johnni" sort="Hansen, Johnni" uniqKey="Hansen J" first="Johnni" last="Hansen">Johnni Hansen</name>
</author>
<author><name sortKey="Schernhammer, Eva" sort="Schernhammer, Eva" uniqKey="Schernhammer E" first="Eva" last="Schernhammer">Eva Schernhammer</name>
</author>
<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2010">2010</date>
<idno type="doi">10.1002/mds.22850</idno>
<idno type="RBID">pubmed:20602449</idno>
<idno type="pmid">20602449</idno>
<idno type="wicri:Area/PubMed/Corpus">001774</idno>
<idno type="wicri:Area/PubMed/Curation">001774</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Major life events and risk of Parkinson's disease.</title>
<author><name sortKey="Rod, Naja Hulvej" sort="Rod, Naja Hulvej" uniqKey="Rod N" first="Naja Hulvej" last="Rod">Naja Hulvej Rod</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Public Health, University of Copenhagen, Department of Social Medicine, Copenhagen, Denmark. n.rod@pubhealth.ku.dk</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Institute of Public Health, University of Copenhagen, Department of Social Medicine, Copenhagen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hansen, Johnni" sort="Hansen, Johnni" uniqKey="Hansen J" first="Johnni" last="Hansen">Johnni Hansen</name>
</author>
<author><name sortKey="Schernhammer, Eva" sort="Schernhammer, Eva" uniqKey="Schernhammer E" first="Eva" last="Schernhammer">Eva Schernhammer</name>
</author>
<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2010" type="published">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Denmark (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Life Change Events</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Denmark</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Life Change Events</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Danemark</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Major life events such as divorce, death of a spouse or a child, or long-term unemployment are stressful to most people and animal models have suggested a link between stress and onset of parkinsonian symptoms. In a large case-control study based on nationwide registries, we aim to address whether major life events are risk factors for Parkinson's disease. Between 1986 and 2006, we identified 13,695 patients with a (PD) primary diagnosis of PD in the Danish National Hospital Register. Each case was frequency matched by age and gender to five population controls. Information on major life events before onset of PD was ascertained from national registries. Among men, number of life events was associated with risk of Parkinson's disease in an inverse dose-response manner (P < 0.0001). Compared to no events, three or more events were associated with a 42% lower risk of PD (OR = 0.58; 95 % CI: 0.34-0.99). Life events were not associated with PD in women. In contrast, a higher risk of PD was observed among women who had never been married (1.16; 1.04-1.29) and among men (1.47; 1.18-1.82) and women (1.30; 1.05-1.61) who have never been employees. The lower risk of Parkinson's disease among men who had experienced life events was unexpected but might suggest a general "risk avoidance behavior" in Parkinson's patients.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20602449</PMID>
<DateCreated><Year>2010</Year>
<Month>08</Month>
<Day>26</Day>
</DateCreated>
<DateCompleted><Year>2010</Year>
<Month>12</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>09</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>25</Volume>
<Issue>11</Issue>
<PubDate><Year>2010</Year>
<Month>Aug</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Major life events and risk of Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>1639-45</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22850</ELocationID>
<Abstract><AbstractText>Major life events such as divorce, death of a spouse or a child, or long-term unemployment are stressful to most people and animal models have suggested a link between stress and onset of parkinsonian symptoms. In a large case-control study based on nationwide registries, we aim to address whether major life events are risk factors for Parkinson's disease. Between 1986 and 2006, we identified 13,695 patients with a (PD) primary diagnosis of PD in the Danish National Hospital Register. Each case was frequency matched by age and gender to five population controls. Information on major life events before onset of PD was ascertained from national registries. Among men, number of life events was associated with risk of Parkinson's disease in an inverse dose-response manner (P < 0.0001). Compared to no events, three or more events were associated with a 42% lower risk of PD (OR = 0.58; 95 % CI: 0.34-0.99). Life events were not associated with PD in women. In contrast, a higher risk of PD was observed among women who had never been married (1.16; 1.04-1.29) and among men (1.47; 1.18-1.82) and women (1.30; 1.05-1.61) who have never been employees. The lower risk of Parkinson's disease among men who had experienced life events was unexpected but might suggest a general "risk avoidance behavior" in Parkinson's patients.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rod</LastName>
<ForeName>Naja Hulvej</ForeName>
<Initials>NH</Initials>
<AffiliationInfo><Affiliation>Institute of Public Health, University of Copenhagen, Department of Social Medicine, Copenhagen, Denmark. n.rod@pubhealth.ku.dk</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hansen</LastName>
<ForeName>Johnni</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schernhammer</LastName>
<ForeName>Eva</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ritz</LastName>
<ForeName>Beate</ForeName>
<Initials>B</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>1 U54 ES12078</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES010544</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES013717</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES013717</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES013717-03</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Lancet. 1999 Dec 18-25;354(9196):2116-8</RefSource>
<PMID Version="1">10609817</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Psychiatry Rep. 2000 Oct;2(5):421-6</RefSource>
<PMID Version="1">11122991</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Physiol Behav. 2002 Dec;77(4-5):527-31</RefSource>
<PMID Version="1">12526994</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1998 Jan 15;338(3):171-9</RefSource>
<PMID Version="1">9428819</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Dan Med Bull. 1999 Jun;46(3):263-8</RefSource>
<PMID Version="1">10421985</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Cancer. 2004 Dec 20;4:94</RefSource>
<PMID Version="1">15610554</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Neurosci. 2008 Apr;27(8):2133-46</RefSource>
<PMID Version="1">18412632</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2005 Feb 12-18;365(9459):622-7</RefSource>
<PMID Version="1">15708109</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Soc Sci Med. 2006 Mar;62(6):1427-42</RefSource>
<PMID Version="1">16162388</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2006 Mar;77(3):317-21</RefSource>
<PMID Version="1">16484638</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2007 Jul;64(7):990-7</RefSource>
<PMID Version="1">17620489</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Rev Neurosci. 2007;18(3-4):209-22</RefSource>
<PMID Version="1">18019607</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2007;13 Suppl 3:S211-20</RefSource>
<PMID Version="1">18267238</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br J Cancer. 2005 Jan 17;92(1):201-5</RefSource>
<PMID Version="1">15583688</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000367">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D003718">Denmark</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008016">Life Change Events</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000523">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012189">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012737">Sex Factors</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">NIHMS150881</OtherID>
<OtherID Source="NLM">PMC2928859</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year>
<Month>7</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2010</Year>
<Month>7</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2010</Year>
<Month>12</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1002/mds.22850</ArticleId>
<ArticleId IdType="pubmed">20602449</ArticleId>
<ArticleId IdType="pmc">PMC2928859</ArticleId>
<ArticleId IdType="mid">NIHMS150881</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001774 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001774 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:20602449 |texte= Major life events and risk of Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:20602449" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |