The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease.
Identifieur interne : 001661 ( PubMed/Curation ); précédent : 001660; suivant : 001662The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease.
Auteurs : Hye Young Sung [Corée du Sud] ; Joong-Seok Kim ; Kwang-Soo Lee ; Yeong-In Kim ; In-Uk Song ; Sung-Woo Chung ; Dong-Won Yang ; Yu Kyung Cho ; Jae Myung Park ; In Seok Lee ; Sang Woo Kim ; In-Sik Chung ; Myung-Gyu ChoiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Deglutition (physiology), Esophageal Motility Disorders (complications), Esophageal Motility Disorders (diagnosis), Esophageal Motility Disorders (epidemiology), Esophagus (physiopathology), Female, Humans, Male, Manometry, Middle Aged, Parkinson Disease (complications), Parkinson Disease (epidemiology), Prevalence, Severity of Illness Index, Statistics as Topic.
- MESH :
- complications : Esophageal Motility Disorders, Parkinson Disease.
- diagnosis : Esophageal Motility Disorders.
- epidemiology : Esophageal Motility Disorders, Parkinson Disease.
- physiology : Deglutition.
- physiopathology : Esophagus.
- Aged, Analysis of Variance, Female, Humans, Male, Manometry, Middle Aged, Prevalence, Severity of Illness Index, Statistics as Topic.
Abstract
Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early-stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty-four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early-stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early-stage PD.
DOI: 10.1002/mds.23290
PubMed: 20669313
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sortKey="Kim, Yeong In" sort="Kim, Yeong In" uniqKey="Kim Y" first="Yeong-In" last="Kim">Yeong-In Kim</name></author><author><name sortKey="Song, In Uk" sort="Song, In Uk" uniqKey="Song I" first="In-Uk" last="Song">In-Uk Song</name></author><author><name sortKey="Chung, Sung Woo" sort="Chung, Sung Woo" uniqKey="Chung S" first="Sung-Woo" last="Chung">Sung-Woo Chung</name></author><author><name sortKey="Yang, Dong Won" sort="Yang, Dong Won" uniqKey="Yang D" first="Dong-Won" last="Yang">Dong-Won Yang</name></author><author><name sortKey="Cho, Yu Kyung" sort="Cho, Yu Kyung" uniqKey="Cho Y" first="Yu Kyung" last="Cho">Yu Kyung Cho</name></author><author><name sortKey="Park, Jae Myung" sort="Park, Jae Myung" uniqKey="Park J" first="Jae Myung" last="Park">Jae Myung Park</name></author><author><name sortKey="Lee, In Seok" sort="Lee, In Seok" uniqKey="Lee I" first="In Seok" last="Lee">In Seok Lee</name></author><author><name sortKey="Kim, Sang Woo" sort="Kim, Sang Woo" uniqKey="Kim S" 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wicri:level="1"><nlm:affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Joong Seok" sort="Kim, Joong Seok" uniqKey="Kim J" first="Joong-Seok" last="Kim">Joong-Seok Kim</name></author><author><name sortKey="Lee, Kwang Soo" sort="Lee, Kwang Soo" uniqKey="Lee K" first="Kwang-Soo" last="Lee">Kwang-Soo Lee</name></author><author><name sortKey="Kim, Yeong In" sort="Kim, Yeong In" uniqKey="Kim Y" first="Yeong-In" last="Kim">Yeong-In Kim</name></author><author><name sortKey="Song, In Uk" sort="Song, In Uk" uniqKey="Song I" first="In-Uk" last="Song">In-Uk Song</name></author><author><name sortKey="Chung, Sung Woo" sort="Chung, Sung Woo" uniqKey="Chung S" first="Sung-Woo" last="Chung">Sung-Woo Chung</name></author><author><name sortKey="Yang, Dong Won" sort="Yang, Dong Won" uniqKey="Yang D" first="Dong-Won" last="Yang">Dong-Won Yang</name></author><author><name sortKey="Cho, Yu Kyung" sort="Cho, Yu Kyung" uniqKey="Cho Y" first="Yu Kyung" last="Cho">Yu Kyung Cho</name></author><author><name sortKey="Park, Jae Myung" sort="Park, Jae Myung" uniqKey="Park J" first="Jae Myung" last="Park">Jae Myung Park</name></author><author><name sortKey="Lee, In Seok" sort="Lee, In Seok" uniqKey="Lee I" first="In Seok" last="Lee">In Seok Lee</name></author><author><name sortKey="Kim, Sang Woo" sort="Kim, Sang Woo" uniqKey="Kim S" first="Sang Woo" last="Kim">Sang Woo Kim</name></author><author><name sortKey="Chung, In Sik" sort="Chung, In Sik" uniqKey="Chung I" first="In-Sik" last="Chung">In-Sik Chung</name></author><author><name sortKey="Choi, Myung Gyu" sort="Choi, Myung Gyu" uniqKey="Choi M" first="Myung-Gyu" last="Choi">Myung-Gyu Choi</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Deglutition (physiology)</term><term>Esophageal Motility Disorders (complications)</term><term>Esophageal Motility Disorders (diagnosis)</term><term>Esophageal Motility Disorders (epidemiology)</term><term>Esophagus (physiopathology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Manometry</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Prevalence</term><term>Severity of Illness Index</term><term>Statistics as Topic</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Esophageal Motility Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Esophageal Motility Disorders</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Esophageal Motility Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Deglutition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Esophagus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Male</term><term>Manometry</term><term>Middle Aged</term><term>Prevalence</term><term>Severity of Illness Index</term><term>Statistics as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early-stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty-four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early-stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early-stage PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20669313</PMID><DateCreated><Year>2010</Year><Month>10</Month><Day>26</Day></DateCreated><DateCompleted><Year>2011</Year><Month>02</Month><Day>22</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>14</Issue><PubDate><Year>2010</Year><Month>Oct</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>2361-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23290</ELocationID><Abstract><AbstractText>Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early-stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty-four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early-stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early-stage PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sung</LastName><ForeName>Hye Young</ForeName><Initials>HY</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Joong-Seok</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Kwang-Soo</ForeName><Initials>KS</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Yeong-In</ForeName><Initials>YI</Initials></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>In-Uk</ForeName><Initials>IU</Initials></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Sung-Woo</ForeName><Initials>SW</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Dong-Won</ForeName><Initials>DW</Initials></Author><Author ValidYN="Y"><LastName>Cho</LastName><ForeName>Yu Kyung</ForeName><Initials>YK</Initials></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Jae Myung</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>In Seok</ForeName><Initials>IS</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Sang Woo</ForeName><Initials>SW</Initials></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>In-Sik</ForeName><Initials>IS</Initials></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Myung-Gyu</ForeName><Initials>MG</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000704">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003679">Deglutition</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015154">Esophageal Motility Disorders</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004947">Esophagus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008365">Manometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015995">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013223">Statistics as Topic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>2</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23290</ArticleId><ArticleId IdType="pubmed">20669313</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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