Facilitated temporal summation of pain at spinal level in Parkinson's disease.
Identifieur interne : 001336 ( PubMed/Curation ); précédent : 001335; suivant : 001337Facilitated temporal summation of pain at spinal level in Parkinson's disease.
Auteurs : Armando Perrotta [Italie] ; Giorgio Sandrini ; Mariano Serrao ; Simona Buscone ; Cristina Tassorelli ; Michele Tinazzi ; Roberta Zangaglia ; Claudio Pacchetti ; Michelangelo Bartolo ; Francesco Pierelli ; Emilia MartignoniSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (therapeutic use), Disability Evaluation, Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Pain (drug therapy), Pain (etiology), Pain (pathology), Pain Measurement, Pain Threshold (drug effects), Pain Threshold (physiology), Parkinson Disease (complications), Parkinson Disease (drug therapy), Physical Stimulation, Psychophysics (methods), Reflex (physiology), Severity of Illness Index, Spinal Cord (physiopathology).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- complications : Parkinson Disease.
- drug effects : Pain Threshold.
- drug therapy : Pain, Parkinson Disease.
- etiology : Pain.
- methods : Psychophysics.
- pathology : Pain.
- physiology : Pain Threshold, Reflex.
- physiopathology : Spinal Cord.
- Adult, Aged, Disability Evaluation, Female, Humans, Male, Middle Aged, Pain Measurement, Physical Stimulation, Severity of Illness Index.
Abstract
Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiopathological substrate to explain the high incidence of diffuse pain symptoms.
DOI: 10.1002/mds.23458
PubMed: 21462260
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Mondino Institute of Neurology Foundation, University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Sandrini, Giorgio" sort="Sandrini, Giorgio" uniqKey="Sandrini G" first="Giorgio" last="Sandrini">Giorgio Sandrini</name></author><author><name sortKey="Serrao, Mariano" sort="Serrao, Mariano" uniqKey="Serrao M" first="Mariano" last="Serrao">Mariano Serrao</name></author><author><name sortKey="Buscone, Simona" sort="Buscone, Simona" uniqKey="Buscone S" first="Simona" last="Buscone">Simona Buscone</name></author><author><name sortKey="Tassorelli, Cristina" sort="Tassorelli, Cristina" uniqKey="Tassorelli C" first="Cristina" last="Tassorelli">Cristina Tassorelli</name></author><author><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name></author><author><name sortKey="Zangaglia, Roberta" sort="Zangaglia, Roberta" uniqKey="Zangaglia R" first="Roberta" last="Zangaglia">Roberta Zangaglia</name></author><author><name sortKey="Pacchetti, Claudio" sort="Pacchetti, Claudio" uniqKey="Pacchetti C" first="Claudio" last="Pacchetti">Claudio Pacchetti</name></author><author><name sortKey="Bartolo, Michelangelo" sort="Bartolo, Michelangelo" uniqKey="Bartolo M" first="Michelangelo" last="Bartolo">Michelangelo Bartolo</name></author><author><name sortKey="Pierelli, Francesco" sort="Pierelli, Francesco" uniqKey="Pierelli F" first="Francesco" last="Pierelli">Francesco Pierelli</name></author><author><name sortKey="Martignoni, Emilia" sort="Martignoni, Emilia" uniqKey="Martignoni E" first="Emilia" last="Martignoni">Emilia Martignoni</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23458</idno><idno type="RBID">pubmed:21462260</idno><idno type="pmid">21462260</idno><idno type="wicri:Area/PubMed/Corpus">001336</idno><idno type="wicri:Area/PubMed/Curation">001336</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Facilitated temporal summation of pain at spinal level in Parkinson's disease.</title><author><name sortKey="Perrotta, Armando" sort="Perrotta, Armando" uniqKey="Perrotta A" first="Armando" last="Perrotta">Armando Perrotta</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, IRCCS C. Mondino Institute of Neurology Foundation, University of Pavia, Pavia, Italy. armando.perrotta@mondino.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, IRCCS C. Mondino Institute of Neurology Foundation, University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Sandrini, Giorgio" sort="Sandrini, Giorgio" uniqKey="Sandrini G" first="Giorgio" last="Sandrini">Giorgio Sandrini</name></author><author><name sortKey="Serrao, Mariano" sort="Serrao, Mariano" uniqKey="Serrao M" first="Mariano" last="Serrao">Mariano Serrao</name></author><author><name sortKey="Buscone, Simona" sort="Buscone, Simona" uniqKey="Buscone S" first="Simona" last="Buscone">Simona Buscone</name></author><author><name sortKey="Tassorelli, Cristina" sort="Tassorelli, Cristina" uniqKey="Tassorelli C" first="Cristina" last="Tassorelli">Cristina Tassorelli</name></author><author><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name></author><author><name sortKey="Zangaglia, Roberta" sort="Zangaglia, Roberta" uniqKey="Zangaglia R" first="Roberta" last="Zangaglia">Roberta Zangaglia</name></author><author><name sortKey="Pacchetti, Claudio" sort="Pacchetti, Claudio" uniqKey="Pacchetti C" first="Claudio" last="Pacchetti">Claudio Pacchetti</name></author><author><name sortKey="Bartolo, Michelangelo" sort="Bartolo, Michelangelo" uniqKey="Bartolo M" first="Michelangelo" last="Bartolo">Michelangelo Bartolo</name></author><author><name sortKey="Pierelli, Francesco" sort="Pierelli, Francesco" uniqKey="Pierelli F" first="Francesco" last="Pierelli">Francesco Pierelli</name></author><author><name sortKey="Martignoni, Emilia" sort="Martignoni, Emilia" uniqKey="Martignoni E" first="Emilia" last="Martignoni">Emilia Martignoni</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Pain (drug therapy)</term><term>Pain (etiology)</term><term>Pain (pathology)</term><term>Pain Measurement</term><term>Pain Threshold (drug effects)</term><term>Pain Threshold (physiology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Physical Stimulation</term><term>Psychophysics (methods)</term><term>Reflex (physiology)</term><term>Severity of Illness Index</term><term>Spinal Cord (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Pain Threshold</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pain</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Psychophysics</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Pain</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Pain Threshold</term><term>Reflex</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Spinal Cord</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pain Measurement</term><term>Physical Stimulation</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiopathological substrate to explain the high incidence of diffuse pain symptoms.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21462260</PMID><DateCreated><Year>2011</Year><Month>04</Month><Day>04</Day></DateCreated><DateCompleted><Year>2011</Year><Month>07</Month><Day>29</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>3</Issue><PubDate><Year>2011</Year><Month>Feb</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Facilitated temporal summation of pain at spinal level in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>442-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23458</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiopathological substrate to explain the high incidence of diffuse pain symptoms.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">We used the temporal summation threshold of the nociceptive withdrawal reflex and the related pain sensation to evaluate the facilitation in pain processing at spinal level. Fifteen (7 Women; 8 Men; mean age 63.0 ± 9.1) Parkinson's disease patients without clinical pain and 12 (6 Women, 6 Men; mean age 61.2 ± 4.2) healthy subjects were recruited. Parkinson's disease group has been subdivided into two subgroups, 7 early-stage Parkinson's disease patients with unilateral signs (Hoehn and Yahr stage 1) and 8 patients in a more advanced stage of the disease showing bilateral parkinsonian signs (Hoehn and Yahr stages 2 and 2.5), both "on" and "off" treatments with levodopa.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A significant facilitation in temporal summation of pain (reduced temporal summation threshold and increased painful sensation) was found in Parkinson's disease patients when compared with controls. This facilitation is more evident in Parkinson's disease with bilateral signs and on the side more affected in Parkinson's disease with unilateral signs. Levodopa administration failed to significantly modify the neurophysiological abnormalities; however, a slight improvement has been detected.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The increased gain in pain processing at spinal level in Parkinson's disease patients could be a consequence of the degenerative phenomena involving supraspinal projections implicated in the modulation of pain processing and could make Parkinson's disease patients more predisposed to develop a pain condition.</AbstractText><CopyrightInformation>Copyright © 2010 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Perrotta</LastName><ForeName>Armando</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, IRCCS C. Mondino Institute of Neurology Foundation, University of Pavia, Pavia, Italy. armando.perrotta@mondino.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sandrini</LastName><ForeName>Giorgio</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Serrao</LastName><ForeName>Mariano</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Buscone</LastName><ForeName>Simona</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Tassorelli</LastName><ForeName>Cristina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Tinazzi</LastName><ForeName>Michele</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Zangaglia</LastName><ForeName>Roberta</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Pacchetti</LastName><ForeName>Claudio</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Bartolo</LastName><ForeName>Michelangelo</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Pierelli</LastName><ForeName>Francesco</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Martignoni</LastName><ForeName>Emilia</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>12</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000978">Antiparkinson Agents</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004185">Disability Evaluation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007980">Levodopa</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010146">Pain</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010147">Pain Measurement</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017288">Pain Threshold</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010812">Physical Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011601">Psychophysics</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012018">Reflex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013116">Spinal Cord</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>6</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>8</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>9</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2010</Year><Month>12</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23458</ArticleId><ArticleId IdType="pubmed">21462260</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce 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