Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops?
Identifieur interne : 001286 ( PubMed/Curation ); précédent : 001285; suivant : 001287Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops?
Auteurs : Carl E. Clarke [Royaume-Uni] ; Smitaa Patel ; Natalie Ives ; Caroline Rick ; Keith Wheatley ; Richard GraySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- methods : Watchful Waiting.
- physiopathology : Parkinson Disease.
- Disability Evaluation, Early Diagnosis, Humans.
Abstract
Evidence from clinical trials with monoamine oxidase type B inhibitors (TEMPO, ADAGIO and DATATOP) and levodopa (ELLDOPA) suggests that Parkinson's disease patients may benefit from treatment being commenced immediately on diagnosis rather than waiting for functional disability to develop, as is traditional clinical practice.
DOI: 10.1002/mds.23519
PubMed: 21495068
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<author><name sortKey="Clarke, Carl E" sort="Clarke, Carl E" uniqKey="Clarke C" first="Carl E" last="Clarke">Carl E. Clarke</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurology, City Hospital, Sandwell and West Birmingham NHS Trust, Dudley Road, Birmingham</wicri:regionArea>
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<author><name sortKey="Patel, Smitaa" sort="Patel, Smitaa" uniqKey="Patel S" first="Smitaa" last="Patel">Smitaa Patel</name>
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<author><name sortKey="Ives, Natalie" sort="Ives, Natalie" uniqKey="Ives N" first="Natalie" last="Ives">Natalie Ives</name>
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<author><name sortKey="Rick, Caroline" sort="Rick, Caroline" uniqKey="Rick C" first="Caroline" last="Rick">Caroline Rick</name>
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<author><name sortKey="Wheatley, Keith" sort="Wheatley, Keith" uniqKey="Wheatley K" first="Keith" last="Wheatley">Keith Wheatley</name>
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<author><name sortKey="Gray, Richard" sort="Gray, Richard" uniqKey="Gray R" first="Richard" last="Gray">Richard Gray</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops?</title>
<author><name sortKey="Clarke, Carl E" sort="Clarke, Carl E" uniqKey="Clarke C" first="Carl E" last="Clarke">Carl E. Clarke</name>
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<author><name sortKey="Rick, Caroline" sort="Rick, Caroline" uniqKey="Rick C" first="Caroline" last="Rick">Caroline Rick</name>
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<author><name sortKey="Wheatley, Keith" sort="Wheatley, Keith" uniqKey="Wheatley K" first="Keith" last="Wheatley">Keith Wheatley</name>
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<term>Disability Evaluation</term>
<term>Early Diagnosis</term>
<term>Humans</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Watchful Waiting (methods)</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Watchful Waiting</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Disability Evaluation</term>
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<front><div type="abstract" xml:lang="en">Evidence from clinical trials with monoamine oxidase type B inhibitors (TEMPO, ADAGIO and DATATOP) and levodopa (ELLDOPA) suggests that Parkinson's disease patients may benefit from treatment being commenced immediately on diagnosis rather than waiting for functional disability to develop, as is traditional clinical practice.</div>
</front>
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<DateCreated><Year>2011</Year>
<Month>06</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2011</Year>
<Month>11</Month>
<Day>02</Day>
</DateCompleted>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>26</Volume>
<Issue>7</Issue>
<PubDate><Year>2011</Year>
<Month>Jun</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops?</ArticleTitle>
<Pagination><MedlinePgn>1187-93</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23519</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Evidence from clinical trials with monoamine oxidase type B inhibitors (TEMPO, ADAGIO and DATATOP) and levodopa (ELLDOPA) suggests that Parkinson's disease patients may benefit from treatment being commenced immediately on diagnosis rather than waiting for functional disability to develop, as is traditional clinical practice.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We performed a narrative literature review and meta-analysis of delayed-start design trials in Parkinson's disease.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">There was inconsistency in the results of the two rasagiline delayed-start design trials, with early treatment with a 2 mg dose significantly superior in the TEMPO trial, but the 1 mg dose significantly better in the ADAGIO trial, making interpretation difficult. Further, the benefits of immediate treatment were small in terms of total unified Parkinson's disease rating scale scores, with a mean difference of 0.91 units (95% confidence interval 0.01, 1.80; P = 0.05) in a meta-analysis of the TEMPO and ADAGIO delayed-start design trials. Such small differences are unlikely to be of clinical relevance. There is also little information on whether immediate treatment has a beneficial effect on patient quality of life with an acceptable adverse reaction profile, and we have no data on whether immediate treatment is cost-effective.</AbstractText>
<AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">Based on the evidence available, changing clinical practice to immediate therapy on diagnosis is not warranted and further trials are needed.</AbstractText>
<CopyrightInformation>Copyright © 2010 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Clarke</LastName>
<ForeName>Carl E</ForeName>
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<AffiliationInfo><Affiliation>Department of Neurology, City Hospital, Sandwell and West Birmingham NHS Trust, Dudley Road, Birmingham, United Kingdom. c.e.clarke@bham.ac.uk</Affiliation>
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<Author ValidYN="Y"><LastName>Patel</LastName>
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<Author ValidYN="Y"><LastName>Ives</LastName>
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