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Rivastigmine as alternative treatment for refractory REM behavior disorder in Parkinson's disease.

Identifieur interne : 000E78 ( PubMed/Curation ); précédent : 000E77; suivant : 000E79

Rivastigmine as alternative treatment for refractory REM behavior disorder in Parkinson's disease.

Auteurs : Raffaella Di Giacopo [Italie] ; Alfonso Fasano ; Davide Quaranta ; Giacomo Della Marca ; Francesco Bove ; Anna Rita Bentivoglio

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.

RBID : pubmed:22290743

English descriptors

KwdEn :
- Aged, Cholinesterase Inhibitors (therapeutic use), Cross-Over Studies, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Phenylcarbamates (therapeutic use), Pilot Projects, Polysomnography, REM Sleep Behavior Disorder (drug therapy), REM Sleep Behavior Disorder (etiology).
MESH :
- chemical , therapeutic use : Cholinesterase Inhibitors, Phenylcarbamates.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease, REM Sleep Behavior Disorder.
- etiology : REM Sleep Behavior Disorder.
- Aged, Cross-Over Studies, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Pilot Projects, Polysomnography.

Abstract

We report on a double-blind, crossover pilot trial for the treatment of rapid eye movement behavior disorder (RBD) in 12 patients with Parkinson's disease in whom conventional therapy failed.

DOI: 10.1002/mds.24909
PubMed: 22290743

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pubmed:22290743

Le document en format XML

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<author><name sortKey="Di Giacopo, Raffaella" sort="Di Giacopo, Raffaella" uniqKey="Di Giacopo R" first="Raffaella" last="Di Giacopo">Raffaella Di Giacopo</name>
<affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Research Center, Department of Neuroscience, Catholic University, Rome, Italy. rdigiacopo@yahoo.it</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Movement Disorders Research Center, Department of Neuroscience, Catholic University, Rome</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name>
</author>
<author><name sortKey="Quaranta, Davide" sort="Quaranta, Davide" uniqKey="Quaranta D" first="Davide" last="Quaranta">Davide Quaranta</name>
</author>
<author><name sortKey="Della Marca, Giacomo" sort="Della Marca, Giacomo" uniqKey="Della Marca G" first="Giacomo" last="Della Marca">Giacomo Della Marca</name>
</author>
<author><name sortKey="Bove, Francesco" sort="Bove, Francesco" uniqKey="Bove F" first="Francesco" last="Bove">Francesco Bove</name>
</author>
<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Rivastigmine as alternative treatment for refractory REM behavior disorder in Parkinson's disease.</title>
<author><name sortKey="Di Giacopo, Raffaella" sort="Di Giacopo, Raffaella" uniqKey="Di Giacopo R" first="Raffaella" last="Di Giacopo">Raffaella Di Giacopo</name>
<affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Research Center, Department of Neuroscience, Catholic University, Rome, Italy. rdigiacopo@yahoo.it</nlm:affiliation>
<country xml:lang="fr">Italie</country>
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<author><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name>
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<author><name sortKey="Quaranta, Davide" sort="Quaranta, Davide" uniqKey="Quaranta D" first="Davide" last="Quaranta">Davide Quaranta</name>
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<author><name sortKey="Della Marca, Giacomo" sort="Della Marca, Giacomo" uniqKey="Della Marca G" first="Giacomo" last="Della Marca">Giacomo Della Marca</name>
</author>
<author><name sortKey="Bove, Francesco" sort="Bove, Francesco" uniqKey="Bove F" first="Francesco" last="Bove">Francesco Bove</name>
</author>
<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2012" type="published">2012</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cholinesterase Inhibitors (therapeutic use)</term>
<term>Cross-Over Studies</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Phenylcarbamates (therapeutic use)</term>
<term>Pilot Projects</term>
<term>Polysomnography</term>
<term>REM Sleep Behavior Disorder (drug therapy)</term>
<term>REM Sleep Behavior Disorder (etiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Cholinesterase Inhibitors</term>
<term>Phenylcarbamates</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
<term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cross-Over Studies</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pilot Projects</term>
<term>Polysomnography</term>
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<front><div type="abstract" xml:lang="en">We report on a double-blind, crossover pilot trial for the treatment of rapid eye movement behavior disorder (RBD) in 12 patients with Parkinson's disease in whom conventional therapy failed.</div>
</front>
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<DateCreated><Year>2012</Year>
<Month>04</Month>
<Day>10</Day>
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<Month>08</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Rivastigmine as alternative treatment for refractory REM behavior disorder in Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>559-61</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.24909</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">We report on a double-blind, crossover pilot trial for the treatment of rapid eye movement behavior disorder (RBD) in 12 patients with Parkinson's disease in whom conventional therapy failed.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We employed a patch of the cholinesterase inhibitor rivastigmine at a dose of 4.6 mg/24 hours for 3 weeks compared with placebo to reduce the frequency of RBD episodes. The number of RBD episodes was monitored by diaries of bed partners.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Rivastigmine was well tolerated in most patients, with minor side effects, mainly related to peripheral cholinergic action, and significantly reduced the mean frequency of RBD episodes during the observation time.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The results of this pilot trial need to be confirmed by further studies on a larger number of patients.</AbstractText>
<CopyrightInformation>Copyright © 2012 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Di Giacopo</LastName>
<ForeName>Raffaella</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Movement Disorders Research Center, Department of Neuroscience, Catholic University, Rome, Italy. rdigiacopo@yahoo.it</Affiliation>
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<Author ValidYN="Y"><LastName>Quaranta</LastName>
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<Author ValidYN="Y"><LastName>Della Marca</LastName>
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<Author ValidYN="Y"><LastName>Bove</LastName>
<ForeName>Francesco</ForeName>
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<Author ValidYN="Y"><LastName>Bentivoglio</LastName>
<ForeName>Anna Rita</ForeName>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType>
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<NameOfSubstance UI="D048448">Phenylcarbamates</NameOfSubstance>
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<Chemical><RegistryNumber>123441-03-2</RegistryNumber>
<NameOfSubstance UI="C072506">rivastigmine</NameOfSubstance>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010865">Pilot Projects</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D017286">Polysomnography</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020187">REM Sleep Behavior Disorder</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName>
</MeshHeading>
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</MedlineCitation>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Rivastigmine as alternative treatment for refractory REM behavior disorder in Parkinson's disease.

Rivastigmine as alternative treatment for refractory REM behavior disorder in Parkinson's disease.

Source :

English descriptors

Abstract

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