Hedonic and behavioral deficits associated with apathy in Parkinson's disease: potential treatment implications.
Identifieur interne : 000894 ( PubMed/Curation ); précédent : 000893; suivant : 000895Hedonic and behavioral deficits associated with apathy in Parkinson's disease: potential treatment implications.
Auteurs : Lizabeth L. Jordan [États-Unis] ; Laura B. Zahodne ; Michael S. Okun ; Dawn BowersSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Behavioral Symptoms.
- physiology : Apathy.
- psychology : Parkinson Disease.
- Aged, Female, Humans, Inhibition (Psychology), Male, Middle Aged, Psychiatric Status Rating Scales, Regression Analysis.
Abstract
Many individuals with Parkinson's disease (PD) experience apathy independent of depression.
DOI: 10.1002/mds.25496
PubMed: 23712560
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hedonic and behavioral deficits associated with apathy in Parkinson's disease: potential treatment implications.</title><author><name sortKey="Jordan, Lizabeth L" sort="Jordan, Lizabeth L" uniqKey="Jordan L" first="Lizabeth L" last="Jordan">Lizabeth L. Jordan</name><affiliation wicri:level="1"><nlm:affiliation>Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B" last="Zahodne">Laura B. Zahodne</name></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S" last="Okun">Michael S. Okun</name></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23712560</idno><idno type="pmid">23712560</idno><idno type="doi">10.1002/mds.25496</idno><idno type="wicri:Area/PubMed/Corpus">000894</idno><idno type="wicri:Area/PubMed/Curation">000894</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hedonic and behavioral deficits associated with apathy in Parkinson's disease: potential treatment implications.</title><author><name sortKey="Jordan, Lizabeth L" sort="Jordan, Lizabeth L" uniqKey="Jordan L" first="Lizabeth L" last="Jordan">Lizabeth L. Jordan</name><affiliation wicri:level="1"><nlm:affiliation>Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B" last="Zahodne">Laura B. Zahodne</name></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S" last="Okun">Michael S. Okun</name></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Apathy (physiology)</term><term>Behavioral Symptoms (etiology)</term><term>Female</term><term>Humans</term><term>Inhibition (Psychology)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (psychology)</term><term>Psychiatric Status Rating Scales</term><term>Regression Analysis</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Behavioral Symptoms</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Apathy</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Inhibition (Psychology)</term><term>Male</term><term>Middle Aged</term><term>Psychiatric Status Rating Scales</term><term>Regression Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many individuals with Parkinson's disease (PD) experience apathy independent of depression.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23712560</PMID><DateCreated><Year>2013</Year><Month>09</Month><Day>04</Day></DateCreated><DateCompleted><Year>2014</Year><Month>04</Month><Day>02</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>9</Issue><PubDate><Year>2013</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Hedonic and behavioral deficits associated with apathy in Parkinson's disease: potential treatment implications.</ArticleTitle><Pagination><MedlinePgn>1301-4</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25496</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Many individuals with Parkinson's disease (PD) experience apathy independent of depression.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In this study, we examined hedonic and behavioral deficits related to apathy in 50 patients with PD and 42 healthy older adults who completed standardized measures.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Regression analyses revealed that apathy was associated with anticipatory, but not consummatory, anhedonia and reduced goal-directed behavior, independent of PD diagnosis, age, education, and depressive symptoms.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings suggest that apathy is characterized by deficits in anticipatory pleasure and behavioral drive rather than consummatory pleasure or reward responsiveness. Therefore, PD patients with apathy would likely benefit from psychotherapeutic treatment that encourages structured, goal-directed plans for pleasurable events and stimulation that provide adaptive hedonic effects. In addition, given the proposed shared mechanism of dopamine depletion within the ventral striatum in apathy and anticipatory anhedonia, future trials of dopamine-eliciting activities (eg, exercise and other nonpharmacologic methods) appear to be warranted to improve these symptoms in patients with PD. © 2013 Movement Disorder Society.</AbstractText><CopyrightInformation>Copyright © 2013 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jordan</LastName><ForeName>Lizabeth L</ForeName><Initials>LL</Initials><AffiliationInfo><Affiliation>Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zahodne</LastName><ForeName>Laura B</ForeName><Initials>LB</Initials></Author><Author ValidYN="Y"><LastName>Okun</LastName><ForeName>Michael S</ForeName><Initials>MS</Initials></Author><Author ValidYN="Y"><LastName>Bowers</LastName><ForeName>Dawn</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01-NS0653</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 NS079767</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21-NS09767</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32-AG020499</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>05</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Clin Neurophysiol. 2006 Oct;117(10):2144-53</RefSource><PMID Version="1">16920018</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2006 Jul 11;67(1):33-8</RefSource><PMID Version="1">16832074</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Affect Disord. 2007 Apr;99(1-3):83-9</RefSource><PMID Version="1">16996138</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Geriatr Psychiatry. 2007 May;15(5):386-94</RefSource><PMID Version="1">17463189</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov 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Version="1">17095520</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D057565">Apathy</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001526">Behavioral Symptoms</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007266">Inhibition (Psychology)</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011569">Psychiatric Status Rating Scales</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012044">Regression Analysis</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS470811</OtherID><OtherID Source="NLM">PMC3760996</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">anhedonia</Keyword><Keyword MajorTopicYN="N">apathy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>6</Month><Day>15</Day></PubMedPubDate><PubMedPubDate 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