Effects of rasagiline on olfactory function in patients with Parkinson’s disease.
Identifieur interne : 000682 ( PubMed/Curation ); précédent : 000681; suivant : 000683Effects of rasagiline on olfactory function in patients with Parkinson’s disease.
Auteurs : Antje Haehner ; Thomas Hummel ; Martin Wolz ; Lisa Klingelhöfer ; Mareike Fauser ; Alexander Storch ; Heinz ReichmannSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Administration, Intranasal, Aged, Double-Blind Method, Electroencephalography, Evoked Potentials, Female, Humans, Indans (therapeutic use), Male, Middle Aged, Neuroprotective Agents (therapeutic use), Olfaction Disorders (drug therapy), Olfaction Disorders (etiology), Olfactometry, Parkinson Disease (complications), Prospective Studies, Psychophysics, Quality of Life, Severity of Illness Index.
- MESH :
- chemical , therapeutic use : Indans, Neuroprotective Agents.
- complications : Parkinson Disease.
- drug therapy : Olfaction Disorders.
- etiology : Olfaction Disorders.
- Administration, Intranasal, Aged, Double-Blind Method, Electroencephalography, Evoked Potentials, Female, Humans, Male, Middle Aged, Olfactometry, Prospective Studies, Psychophysics, Quality of Life, Severity of Illness Index.
Abstract
Impairment of olfactory function is a well recognized nonmotor manifestation of Parkinson’s disease(PD). The aim of this investigation was to determine if the MAO-B inhibitor rasagiline can improve olfaction in PD patients.
DOI: 10.1002/mds.25661
PubMed: 24190245
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pubmed:24190245Le document en format XML
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<author><name sortKey="Haehner, Antje" sort="Haehner, Antje" uniqKey="Haehner A" first="Antje" last="Haehner">Antje Haehner</name>
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<author><name sortKey="Hummel, Thomas" sort="Hummel, Thomas" uniqKey="Hummel T" first="Thomas" last="Hummel">Thomas Hummel</name>
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<author><name sortKey="Wolz, Martin" sort="Wolz, Martin" uniqKey="Wolz M" first="Martin" last="Wolz">Martin Wolz</name>
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<author><name sortKey="Klingelhofer, Lisa" sort="Klingelhofer, Lisa" uniqKey="Klingelhofer L" first="Lisa" last="Klingelhöfer">Lisa Klingelhöfer</name>
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<author><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of rasagiline on olfactory function in patients with Parkinson’s disease.</title>
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<author><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Female</term>
<term>Humans</term>
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<term>Neuroprotective Agents (therapeutic use)</term>
<term>Olfaction Disorders (drug therapy)</term>
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<term>Parkinson Disease (complications)</term>
<term>Prospective Studies</term>
<term>Psychophysics</term>
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<term>Severity of Illness Index</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Indans</term>
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<term>Aged</term>
<term>Double-Blind Method</term>
<term>Electroencephalography</term>
<term>Evoked Potentials</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Olfactometry</term>
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<front><div type="abstract" xml:lang="en">Impairment of olfactory function is a well recognized nonmotor manifestation of Parkinson’s disease(PD). The aim of this investigation was to determine if the MAO-B inhibitor rasagiline can improve olfaction in PD patients.</div>
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<Month>01</Month>
<Day>25</Day>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Effects of rasagiline on olfactory function in patients with Parkinson’s disease.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Impairment of olfactory function is a well recognized nonmotor manifestation of Parkinson’s disease(PD). The aim of this investigation was to determine if the MAO-B inhibitor rasagiline can improve olfaction in PD patients.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Thirty-four PD patients participated in this single-center, prospective, randomized, controlled,double-blind study. Seventeen patients were randomly assigned to rasagiline and 17 patients to placebo. Orthoand retronasal olfactory testing and recording of event related potentials were performed before and after 120 days of rasagiline versus placebo intake.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">When comparing olfactory score differences between baseline and after 120 days between the 2 groups, the level of significance was not reached.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The primary end point of the study was not reached, and therefore, a specific effect of rasagiline on olfactory function in PD could not be demonstrated.</AbstractText>
</Abstract>
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