MovDisordV3, PubMed, Curation, bibRecord, 000418

Onset of Huntington's disease: can it be purely cognitive?

Identifieur interne : 000418 ( PubMed/Curation ); précédent : 000417; suivant : 000419

Onset of Huntington's disease: can it be purely cognitive?

Auteurs : Jane S. Paulsen [États-Unis] ; Jeffrey D. Long

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.

RBID : pubmed:25142616

English descriptors

KwdEn :
- Adult, Cognition Disorders (diagnosis), Cognition Disorders (etiology), Female, Humans, Huntington Disease (complications), Huntington Disease (genetics), Longitudinal Studies, Male, Middle Aged, Nerve Tissue Proteins (genetics), Neuropsychological Tests, Severity of Illness Index, Trinucleotide Repeat Expansion (genetics).
MESH :
- chemical , genetics : Nerve Tissue Proteins.
- complications : Huntington Disease.
- diagnosis : Cognition Disorders.
- etiology : Cognition Disorders.
- genetics : Huntington Disease, Trinucleotide Repeat Expansion.
- Adult, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.

Abstract

Knowledge of the cognitive manifestation of Huntington's disease has burgeoned over the past two decades. Many studies from independent datasets have shown that cognitive impairment is evident before motor diagnosis, and annual cognitive decline is a robust marker of disease progression. Additionally, cognition is a critical concern to patients and families and is associated with meaningful outcomes, including functional capacity, driving, loss of accustomed work, and quality of life. In the past few years, Huntington's disease animal models of cognition have increased, preparing for preclinical experimental therapeutics with cognitive endpoints. A longitudinal analysis of cognitive variables was conducted with 559 gene-positive cases and 233 controls showing no signs of motor abnormalities over approximately a 3-year period. Results show statistically significant differences in rate of annual change for some cognitive variables, such that the cases group had worsening performance over time. These findings show that cognitive deterioration can be seen in persons with the Huntington's disease gene expansion with no overt motor signs or symptoms, suggesting that cognitive onset of Huntington's disease may precede motor.

DOI: 10.1002/mds.25997
PubMed: 25142616

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Le document en format XML

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<author><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane S" last="Paulsen">Jane S. Paulsen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA; Department of Neurology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA; Department of Psychology, The University of Iowa, Iowa City, IA, USA.</nlm:affiliation>
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<wicri:regionArea>Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA; Department of Neurology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA; Department of Psychology, The University of Iowa, Iowa City, IA</wicri:regionArea>
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<front><div type="abstract" xml:lang="en">Knowledge of the cognitive manifestation of Huntington's disease has burgeoned over the past two decades. Many studies from independent datasets have shown that cognitive impairment is evident before motor diagnosis, and annual cognitive decline is a robust marker of disease progression. Additionally, cognition is a critical concern to patients and families and is associated with meaningful outcomes, including functional capacity, driving, loss of accustomed work, and quality of life. In the past few years, Huntington's disease animal models of cognition have increased, preparing for preclinical experimental therapeutics with cognitive endpoints. A longitudinal analysis of cognitive variables was conducted with 559 gene-positive cases and 233 controls showing no signs of motor abnormalities over approximately a 3-year period. Results show statistically significant differences in rate of annual change for some cognitive variables, such that the cases group had worsening performance over time. These findings show that cognitive deterioration can be seen in persons with the Huntington's disease gene expansion with no overt motor signs or symptoms, suggesting that cognitive onset of Huntington's disease may precede motor.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Onset of Huntington's disease: can it be purely cognitive?

Onset of Huntington's disease: can it be purely cognitive?

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