Clinical markers for identifying cholinergic deficits in Parkinson's disease.
Identifieur interne : 000346 ( PubMed/Curation ); précédent : 000345; suivant : 000347Clinical markers for identifying cholinergic deficits in Parkinson's disease.
Auteurs : Martijn L T M. Müller [États-Unis] ; Nicolaas I. Bohnen ; Vikas Kotagal ; Peter J H. Scott ; Robert A. Koeppe ; Kirk A. Frey ; Roger L. AlbinSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Acetylcholine (metabolism), Adult, Aged, Aged, 80 and over, Biological Markers (analysis), Cholinergic Neurons (metabolism), Dopamine (metabolism), Female, Humans, Male, Middle Aged, Parkinson Disease (diagnosis), Positron-Emission Tomography (methods), REM Sleep Behavior Disorder (diagnosis), Retrospective Studies.
- MESH :
- chemical , analysis : Biological Markers.
- chemical , metabolism : Acetylcholine, Dopamine.
- diagnosis : Parkinson Disease, REM Sleep Behavior Disorder.
- metabolism : Cholinergic Neurons.
- methods : Positron-Emission Tomography.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies.
Abstract
Cholinergic projection systems degeneration is associated with dopamine nonresponsive features of Parkinson's disease (PD). Cholinergic deficits are variable in nondemented PD. Identification of cholinergic deficits in PD may help with selection of suitable patients for targeted cholinergic drug treatment in PD. The objective of this retrospective multivariate predictor analysis study was to identify clinical markers indicative of cholinergic deficits in PD patients, as assessed by acetylcholinesterase ([(11) C]PMP) positron emission tomography.
DOI: 10.1002/mds.26061
PubMed: 25393613
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical markers for identifying cholinergic deficits in Parkinson's disease.</title><author><name sortKey="Muller, Martijn L T M" sort="Muller, Martijn L T M" uniqKey="Muller M" first="Martijn L T M" last="Müller">Martijn L T M. Müller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of Michigan, Ann Arbor, Michigan</wicri:regionArea></affiliation></author><author><name sortKey="Bohnen, Nicolaas I" sort="Bohnen, Nicolaas I" uniqKey="Bohnen N" first="Nicolaas I" last="Bohnen">Nicolaas I. Bohnen</name></author><author><name sortKey="Kotagal, Vikas" sort="Kotagal, Vikas" uniqKey="Kotagal V" first="Vikas" last="Kotagal">Vikas Kotagal</name></author><author><name sortKey="Scott, Peter J H" sort="Scott, Peter J H" uniqKey="Scott P" first="Peter J H" last="Scott">Peter J H. Scott</name></author><author><name sortKey="Koeppe, Robert A" sort="Koeppe, Robert A" uniqKey="Koeppe R" first="Robert A" last="Koeppe">Robert A. Koeppe</name></author><author><name sortKey="Frey, Kirk A" sort="Frey, Kirk A" uniqKey="Frey K" first="Kirk A" last="Frey">Kirk A. Frey</name></author><author><name sortKey="Albin, Roger L" sort="Albin, Roger L" uniqKey="Albin R" first="Roger L" last="Albin">Roger L. Albin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25393613</idno><idno type="pmid">25393613</idno><idno type="doi">10.1002/mds.26061</idno><idno type="wicri:Area/PubMed/Corpus">000346</idno><idno type="wicri:Area/PubMed/Curation">000346</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical markers for identifying cholinergic deficits in Parkinson's disease.</title><author><name sortKey="Muller, Martijn L T M" sort="Muller, Martijn L T M" uniqKey="Muller M" first="Martijn L T M" last="Müller">Martijn L T M. Müller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of Michigan, Ann Arbor, Michigan</wicri:regionArea></affiliation></author><author><name sortKey="Bohnen, Nicolaas I" sort="Bohnen, Nicolaas I" uniqKey="Bohnen N" first="Nicolaas I" last="Bohnen">Nicolaas I. Bohnen</name></author><author><name sortKey="Kotagal, Vikas" sort="Kotagal, Vikas" uniqKey="Kotagal V" first="Vikas" last="Kotagal">Vikas Kotagal</name></author><author><name sortKey="Scott, Peter J H" sort="Scott, Peter J H" uniqKey="Scott P" first="Peter J H" last="Scott">Peter J H. Scott</name></author><author><name sortKey="Koeppe, Robert A" sort="Koeppe, Robert A" uniqKey="Koeppe R" first="Robert A" last="Koeppe">Robert A. Koeppe</name></author><author><name sortKey="Frey, Kirk A" sort="Frey, Kirk A" uniqKey="Frey K" first="Kirk A" last="Frey">Kirk A. Frey</name></author><author><name sortKey="Albin, Roger L" sort="Albin, Roger L" uniqKey="Albin R" first="Roger L" last="Albin">Roger L. Albin</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholine (metabolism)</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Biological Markers (analysis)</term><term>Cholinergic Neurons (metabolism)</term><term>Dopamine (metabolism)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Positron-Emission Tomography (methods)</term><term>REM Sleep Behavior Disorder (diagnosis)</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biological Markers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acetylcholine</term><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cholinergic Neurons</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cholinergic projection systems degeneration is associated with dopamine nonresponsive features of Parkinson's disease (PD). Cholinergic deficits are variable in nondemented PD. Identification of cholinergic deficits in PD may help with selection of suitable patients for targeted cholinergic drug treatment in PD. The objective of this retrospective multivariate predictor analysis study was to identify clinical markers indicative of cholinergic deficits in PD patients, as assessed by acetylcholinesterase ([(11) C]PMP) positron emission tomography.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25393613</PMID><DateCreated><Year>2015</Year><Month>02</Month><Day>04</Day></DateCreated><DateCompleted><Year>2015</Year><Month>10</Month><Day>22</Day></DateCompleted><DateRevised><Year>2015</Year><Month>02</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Clinical markers for identifying cholinergic deficits in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>269-73</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26061</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Cholinergic projection systems degeneration is associated with dopamine nonresponsive features of Parkinson's disease (PD). Cholinergic deficits are variable in nondemented PD. Identification of cholinergic deficits in PD may help with selection of suitable patients for targeted cholinergic drug treatment in PD. The objective of this retrospective multivariate predictor analysis study was to identify clinical markers indicative of cholinergic deficits in PD patients, as assessed by acetylcholinesterase ([(11) C]PMP) positron emission tomography.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">One hundred thirty-seven PD patients (34 female) participated; median modified Hoehn and Yahr score was 2.5 (range, 1-4), average age 65.6 ± 7.4 years, and average duration of motor disease symptoms of 6.0 ± 4.2 years. Subjects were dichotomized as "normocholinergic" or "hypocholinergic" based on a 5(th) percentile cutoff from normal for the basal forebrain-cortical and pedunculopontine nucleus-thalamic cholinergic projection systems. Previously identified clinical indices of cholinergic denervation were used for statistical prediction of cholinergic deficits. Logistic regression determined which risk factors predicted cholinergic deficits. Sensitivity, specificity, and accuracy were determined for the (combinations of) significant predictor variables.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Forty-nine (35.8%) hypocholinergic PD subjects were identified. The combination of rapid eye movement (REM) sleep behavior disorder (RBD) symptoms and fall history showed highest diagnostic accuracy (81.1%) for predicting combined thalamic and cortical cholinergic deficits. A combined assessment of 8.5 m walk time and lower score on the Montreal cognitive assessment scale provided diagnostic accuracy of 80.7% for predicting isolated cortical cholinergic denervation.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Assessment of clinical indices of cholinergic denervation may be useful for identifying suitable subjects for trials of targeted cholinergic drug treatments in PD.</AbstractText><CopyrightInformation>© 2014 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Martijn L T M</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bohnen</LastName><ForeName>Nicolaas I</ForeName><Initials>NI</Initials></Author><Author ValidYN="Y"><LastName>Kotagal</LastName><ForeName>Vikas</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Peter J H</ForeName><Initials>PJ</Initials></Author><Author ValidYN="Y"><LastName>Koeppe</LastName><ForeName>Robert A</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>Frey</LastName><ForeName>Kirk A</ForeName><Initials>KA</Initials></Author><Author ValidYN="Y"><LastName>Albin</LastName><ForeName>Roger L</ForeName><Initials>RL</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P01 NS015655</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 NS015655</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS07085</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS070856</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biological Markers</NameOfSubstance></Chemical><Chemical><RegistryNumber>N9YNS0M02X</RegistryNumber><NameOfSubstance UI="D000109">Acetylcholine</NameOfSubstance></Chemical><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2012 Apr;71(4):560-8</RefSource><PMID Version="1">22522445</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2011 Dec;26(14):2496-503</RefSource><PMID Version="1">21898597</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2013 Mar;28(3):296-301</RefSource><PMID Version="1">23239424</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cereb Blood Flow Metab. 2012 Aug;32(8):1609-17</RefSource><PMID Version="1">22569194</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2012 Aug;11(8):697-707</RefSource><PMID 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May;19(5):522-6</RefSource><PMID Version="1">23462483</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000109">Acetylcholine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015415">Biological Markers</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000032">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D059329">Cholinergic Neurons</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004298">Dopamine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D049268">Positron-Emission Tomography</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020187">REM Sleep Behavior Disorder</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012189">Retrospective Studies</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS633804 [Available on 02/01/16]</OtherID><OtherID Source="NLM">PMC4318774 [Available on 02/01/16]</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">PET</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">acetylcholine</Keyword><Keyword MajorTopicYN="N">acetylcholinesterase</Keyword><Keyword MajorTopicYN="N">biomarkers</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>5</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>10</Month><Day>3</Day></PubMedPubDate><PubMedPubDate 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