Population prevalence of Tourette syndrome: a systematic review and meta-analysis.
Identifieur interne : 000321 ( PubMed/Curation ); précédent : 000320; suivant : 000322Population prevalence of Tourette syndrome: a systematic review and meta-analysis.
Auteurs : Jeremiah M. Scharf [États-Unis] ; Laura L. Miller ; Caitlin A. Gauvin ; Janelle Alabiso ; Carol A. Mathews ; Yoav Ben-ShlomoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Tourette Syndrome.
- methods : Data Collection.
- Child, Child, Preschool, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Male, Patient Selection, Prevalence, Sample Size.
Abstract
The aim of this study was to refine the population prevalence estimate of Tourette Syndrome (TS) in children and to investigate potential sources of heterogeneity in previously published studies. A systematic review was conducted and all qualifying published studies of TS prevalence were examined. Extracted data were subjected to a random-effects meta-analysis weighted by sample size; meta-regressions were performed to examine covariates that have previously been proposed as potential sources of heterogeneity. Twenty-six articles met study inclusion criteria. Studies derived from clinically referred cases had prevalence estimates that were significantly lower than those derived from population-based samples (P = 0.004). Among the 21 population-based prevalence studies, the pooled TS population prevalence estimate was 0.52% (95% confidence interval CI: 0.32-0.85). In univariable meta-regression analysis, study sample size (P = 0.002) and study date (P = 0.03) were significant predictors of TS prevalence. In the final multivariable model including sample size, study date, age, and diagnostic criteria, only sample size (P < 0.001) and diagnostic criteria (omnibus P = 0.003; Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision [DSM-IV-TR]: P = 0.005) were independently associated with variation in TS population prevalence across studies. This study refines the population prevalence estimate of TS in children to be 0.3% to 0.9%. Study sample size, which is likely a proxy for case assessment method, and the use of DSM-IV-TR diagnostic criteria are the major sources of heterogeneity across studies. The true TS population prevalence rate is likely at the higher end of these estimates, given the methodological limitations of most studies. Further studies in large, well-characterized samples will be helpful to determine the burden of disease in the general population.
DOI: 10.1002/mds.26089
PubMed: 25487709
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Scharf</name><affiliation wicri:level="1"><nlm:affiliation>Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Departments of Neurology and Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA; Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Departments of Neurology and Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA; Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Miller, Laura L" sort="Miller, Laura L" uniqKey="Miller L" first="Laura L" last="Miller">Laura L. Miller</name></author><author><name sortKey="Gauvin, Caitlin A" sort="Gauvin, Caitlin A" uniqKey="Gauvin C" first="Caitlin A" last="Gauvin">Caitlin A. Gauvin</name></author><author><name sortKey="Alabiso, Janelle" sort="Alabiso, Janelle" uniqKey="Alabiso J" first="Janelle" last="Alabiso">Janelle Alabiso</name></author><author><name sortKey="Mathews, Carol A" sort="Mathews, Carol A" uniqKey="Mathews C" first="Carol A" last="Mathews">Carol A. Mathews</name></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25487709</idno><idno type="pmid">25487709</idno><idno type="doi">10.1002/mds.26089</idno><idno type="wicri:Area/PubMed/Corpus">000321</idno><idno type="wicri:Area/PubMed/Curation">000321</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Population prevalence of Tourette syndrome: a systematic review and meta-analysis.</title><author><name sortKey="Scharf, Jeremiah M" sort="Scharf, Jeremiah M" uniqKey="Scharf J" first="Jeremiah M" last="Scharf">Jeremiah M. Scharf</name><affiliation wicri:level="1"><nlm:affiliation>Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Departments of Neurology and Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA; Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Departments of Neurology and Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA; Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Miller, Laura L" sort="Miller, Laura L" uniqKey="Miller L" first="Laura L" last="Miller">Laura L. Miller</name></author><author><name sortKey="Gauvin, Caitlin A" sort="Gauvin, Caitlin A" uniqKey="Gauvin C" first="Caitlin A" last="Gauvin">Caitlin A. Gauvin</name></author><author><name sortKey="Alabiso, Janelle" sort="Alabiso, Janelle" uniqKey="Alabiso J" first="Janelle" last="Alabiso">Janelle Alabiso</name></author><author><name sortKey="Mathews, Carol A" sort="Mathews, Carol A" uniqKey="Mathews C" first="Carol A" last="Mathews">Carol A. Mathews</name></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Data Collection (methods)</term><term>Diagnostic and Statistical Manual of Mental Disorders</term><term>Female</term><term>Humans</term><term>Male</term><term>Patient Selection</term><term>Prevalence</term><term>Sample Size</term><term>Tourette Syndrome (epidemiology)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Data Collection</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Diagnostic and Statistical Manual of Mental Disorders</term><term>Female</term><term>Humans</term><term>Male</term><term>Patient Selection</term><term>Prevalence</term><term>Sample Size</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to refine the population prevalence estimate of Tourette Syndrome (TS) in children and to investigate potential sources of heterogeneity in previously published studies. A systematic review was conducted and all qualifying published studies of TS prevalence were examined. Extracted data were subjected to a random-effects meta-analysis weighted by sample size; meta-regressions were performed to examine covariates that have previously been proposed as potential sources of heterogeneity. Twenty-six articles met study inclusion criteria. Studies derived from clinically referred cases had prevalence estimates that were significantly lower than those derived from population-based samples (P = 0.004). Among the 21 population-based prevalence studies, the pooled TS population prevalence estimate was 0.52% (95% confidence interval CI: 0.32-0.85). In univariable meta-regression analysis, study sample size (P = 0.002) and study date (P = 0.03) were significant predictors of TS prevalence. In the final multivariable model including sample size, study date, age, and diagnostic criteria, only sample size (P < 0.001) and diagnostic criteria (omnibus P = 0.003; Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision [DSM-IV-TR]: P = 0.005) were independently associated with variation in TS population prevalence across studies. This study refines the population prevalence estimate of TS in children to be 0.3% to 0.9%. Study sample size, which is likely a proxy for case assessment method, and the use of DSM-IV-TR diagnostic criteria are the major sources of heterogeneity across studies. The true TS population prevalence rate is likely at the higher end of these estimates, given the methodological limitations of most studies. Further studies in large, well-characterized samples will be helpful to determine the burden of disease in the general population.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25487709</PMID><DateCreated><Year>2015</Year><Month>02</Month><Day>04</Day></DateCreated><DateCompleted><Year>2015</Year><Month>10</Month><Day>22</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Population prevalence of Tourette syndrome: a systematic review and meta-analysis.</ArticleTitle><Pagination><MedlinePgn>221-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26089</ELocationID><Abstract><AbstractText>The aim of this study was to refine the population prevalence estimate of Tourette Syndrome (TS) in children and to investigate potential sources of heterogeneity in previously published studies. A systematic review was conducted and all qualifying published studies of TS prevalence were examined. Extracted data were subjected to a random-effects meta-analysis weighted by sample size; meta-regressions were performed to examine covariates that have previously been proposed as potential sources of heterogeneity. Twenty-six articles met study inclusion criteria. Studies derived from clinically referred cases had prevalence estimates that were significantly lower than those derived from population-based samples (P = 0.004). Among the 21 population-based prevalence studies, the pooled TS population prevalence estimate was 0.52% (95% confidence interval CI: 0.32-0.85). In univariable meta-regression analysis, study sample size (P = 0.002) and study date (P = 0.03) were significant predictors of TS prevalence. In the final multivariable model including sample size, study date, age, and diagnostic criteria, only sample size (P < 0.001) and diagnostic criteria (omnibus P = 0.003; Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision [DSM-IV-TR]: P = 0.005) were independently associated with variation in TS population prevalence across studies. This study refines the population prevalence estimate of TS in children to be 0.3% to 0.9%. Study sample size, which is likely a proxy for case assessment method, and the use of DSM-IV-TR diagnostic criteria are the major sources of heterogeneity across studies. The true TS population prevalence rate is likely at the higher end of these estimates, given the methodological limitations of most studies. Further studies in large, well-characterized samples will be helpful to determine the burden of disease in the general population.</AbstractText><CopyrightInformation>© 2014 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Scharf</LastName><ForeName>Jeremiah M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Departments of Neurology and Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA; Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Laura L</ForeName><Initials>LL</Initials></Author><Author ValidYN="Y"><LastName>Gauvin</LastName><ForeName>Caitlin A</ForeName><Initials>CA</Initials></Author><Author ValidYN="Y"><LastName>Alabiso</LastName><ForeName>Janelle</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Mathews</LastName><ForeName>Carol A</ForeName><Initials>CA</Initials></Author><Author ValidYN="Y"><LastName>Ben-Shlomo</LastName><ForeName>Yoav</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MH080857</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>12</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002648">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002675">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003625">Data Collection</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D039721">Diagnostic and Statistical Manual of Mental Disorders</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018579">Patient Selection</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015995">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018401">Sample Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005879">Tourette Syndrome</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Tourette syndrome</Keyword><Keyword MajorTopicYN="N">developmental disorders</Keyword><Keyword MajorTopicYN="N">meta-analysis</Keyword><Keyword MajorTopicYN="N">prevalence studies</Keyword><Keyword MajorTopicYN="N">tics</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>6</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>10</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>10</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>12</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>10</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25487709</ArticleId><ArticleId IdType="doi">10.1002/mds.26089</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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