Zonisamide improves wearing-off in Parkinson's disease: A randomized, double-blind study.
Identifieur interne : 000149 ( PubMed/Curation ); précédent : 000148; suivant : 000150Zonisamide improves wearing-off in Parkinson's disease: A randomized, double-blind study.
Auteurs : Miho Murata [Japon] ; Kazuko Hasegawa [Japon] ; Ichiro Kanazawa [Japon] ; Junichi Fukasaka [Japon] ; Kenji Kochi [Japon] ; Rieko Shimazu [Japon]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Previously, we reported 50 mg/d zonisamide improved wearing-off without increasing dyskinesia in patients with Parkinson's disease (PD).
DOI: 10.1002/mds.26286
PubMed: 26094993
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uniqKey="Kochi K" first="Kenji" last="Kochi">Kenji Kochi</name><affiliation wicri:level="1"><nlm:affiliation>Sumitomo Dainippon Pharma Co., Ltd, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Sumitomo Dainippon Pharma Co., Ltd, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Shimazu, Rieko" sort="Shimazu, Rieko" uniqKey="Shimazu R" first="Rieko" last="Shimazu">Rieko Shimazu</name><affiliation wicri:level="1"><nlm:affiliation>Sumitomo Dainippon Pharma Co., Ltd, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Sumitomo Dainippon Pharma Co., Ltd, Tokyo</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26094993</idno><idno type="pmid">26094993</idno><idno type="doi">10.1002/mds.26286</idno><idno type="wicri:Area/PubMed/Corpus">000149</idno><idno type="wicri:Area/PubMed/Curation">000149</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Zonisamide improves wearing-off in Parkinson's disease: A randomized, double-blind study.</title><author><name sortKey="Murata, Miho" sort="Murata, Miho" uniqKey="Murata M" first="Miho" last="Murata">Miho Murata</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Sagamihara National Hospital, Kanagawa, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Sagamihara National Hospital, Kanagawa</wicri:regionArea></affiliation></author><author><name sortKey="Kanazawa, Ichiro" sort="Kanazawa, Ichiro" uniqKey="Kanazawa I" first="Ichiro" last="Kanazawa">Ichiro Kanazawa</name><affiliation wicri:level="1"><nlm:affiliation>International University of Health and Welfare Graduate School, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>International University of Health and Welfare Graduate School, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Fukasaka, Junichi" sort="Fukasaka, Junichi" uniqKey="Fukasaka J" first="Junichi" last="Fukasaka">Junichi Fukasaka</name><affiliation wicri:level="1"><nlm:affiliation>Sumitomo Dainippon Pharma Co., Ltd, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Sumitomo Dainippon Pharma Co., Ltd, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Kochi, Kenji" sort="Kochi, Kenji" uniqKey="Kochi K" first="Kenji" last="Kochi">Kenji Kochi</name><affiliation wicri:level="1"><nlm:affiliation>Sumitomo Dainippon Pharma Co., Ltd, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Sumitomo Dainippon Pharma Co., Ltd, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Shimazu, Rieko" sort="Shimazu, Rieko" uniqKey="Shimazu R" first="Rieko" last="Shimazu">Rieko Shimazu</name><affiliation wicri:level="1"><nlm:affiliation>Sumitomo Dainippon Pharma Co., Ltd, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Sumitomo Dainippon Pharma Co., Ltd, Tokyo</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previously, we reported 50 mg/d zonisamide improved wearing-off without increasing dyskinesia in patients with Parkinson's disease (PD).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">26094993</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>03</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>10</Issue><PubDate><Year>2015</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Zonisamide improves wearing-off in Parkinson's disease: A randomized, double-blind study.</ArticleTitle><Pagination><MedlinePgn>1343-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26286</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Previously, we reported 50 mg/d zonisamide improved wearing-off without increasing dyskinesia in patients with Parkinson's disease (PD).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">To determine the efficacy of zonisamide for treatment of "off" time in PD patients, we conducted a multicenter, randomized, double-blind, parallel-group, placebo-controlled study in Japan. Patients with PD and wearing-off received placebo for 4 weeks and then were treated for 12 weeks with zonisamide 25 or 50 mg/d or placebo, in addition to their previous therapy. The primary endpoint was the change from baseline in daily "off" time as determined by patients' diaries at the final assessment. Secondary endpoints included changes from baseline in the total scores of the Unified Parkinson's Disease Rating Scale Parts I, II, III, and IV, the dyskinesia duration, and PDQ-39 score.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 422 patients enrolled, 389 (131 for placebo, 130 for zonisamide 25 mg, and 128 for zonisamide 50 mg) were randomized, and 354 (120, 119, and 115, respectively) completed the study. The "off" time significantly reduced by 0.719 ± 0.179 h for zonisamide, 50 mg compared with placebo (0.011 ± 0.173 h, P = 0.005). Although the incidence of somnolence was higher for zonisamide (3.1% for zonisamide 25 mg, 6.3% for zonisamide 50 mg) than for placebo (2.3%), the incidences of the other adverse events, including dyskinesia or hallucination, for both zonisamide treatments were comparable to those for placebo.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The study provides evidence that confirms the efficacy of zonisamide 50 mg/d for reduction in "off" time in PD patients with wearing-off phenomena.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Murata</LastName><ForeName>Miho</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hasegawa</LastName><ForeName>Kazuko</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, Sagamihara National Hospital, Kanagawa, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kanazawa</LastName><ForeName>Ichiro</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>International University of Health and Welfare Graduate School, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fukasaka</LastName><ForeName>Junichi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Sumitomo Dainippon Pharma Co., Ltd, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kochi</LastName><ForeName>Kenji</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Sumitomo Dainippon Pharma Co., Ltd, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author 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