A preoperative metabolic marker of parkinsonian apathy following subthalamic nucleus stimulation.
Identifieur interne : 000085 ( PubMed/Curation ); précédent : 000084; suivant : 000086A preoperative metabolic marker of parkinsonian apathy following subthalamic nucleus stimulation.
Auteurs : Aude Gesquière-Dando [France] ; Eric Guedj [France] ; Anderson Loundou [France] ; Romain Carron [France] ; Tatiana Witjas [France] ; Frédérique Fluchère [France] ; Marie Delfini [France] ; Laura Mundler [France] ; Jean Regis [France] ; Jean-Philippe Azulay [France] ; Alexandre Eusebio [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) has been associated with the development of postoperative apathy. Debate on the causes of postoperative apathy continues, and the dominant hypothesis is that stimulation or dopaminergic drug reductions are causal in its development. We hypothesized that a preoperative predisposition to apathy also could exist. To this end, we sought to identify a preoperative metabolic pattern using [(18) ]Fluorodeoxyglucose Positron Emission Tomography (PET), which could be associated with the occurrence of postoperative apathy after STN-DBS for PD.
DOI: 10.1002/mds.26349
PubMed: 26228098
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Guedj</name><affiliation wicri:level="1"><nlm:affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Loundou, Anderson" sort="Loundou, Anderson" uniqKey="Loundou A" first="Anderson" last="Loundou">Anderson Loundou</name><affiliation wicri:level="1"><nlm:affiliation>APHM, CHU Timone, Unité d'Aide méthodologique à la Recherche Clinique et Epidémiologique, DRRC, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Unité d'Aide méthodologique à la Recherche Clinique et Epidémiologique, DRRC, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Carron, Romain" sort="Carron, Romain" uniqKey="Carron R" first="Romain" last="Carron">Romain Carron</name><affiliation wicri:level="1"><nlm:affiliation>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name><affiliation wicri:level="1"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Fluchere, Frederique" sort="Fluchere, Frederique" uniqKey="Fluchere F" first="Frédérique" last="Fluchère">Frédérique Fluchère</name><affiliation wicri:level="1"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Delfini, Marie" sort="Delfini, Marie" uniqKey="Delfini M" first="Marie" last="Delfini">Marie Delfini</name><affiliation wicri:level="1"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Mundler, Laura" sort="Mundler, Laura" uniqKey="Mundler L" first="Laura" last="Mundler">Laura Mundler</name><affiliation wicri:level="1"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Regis, Jean" sort="Regis, Jean" uniqKey="Regis J" first="Jean" last="Regis">Jean Regis</name><affiliation wicri:level="1"><nlm:affiliation>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><affiliation wicri:level="1"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation wicri:level="1"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) has been associated with the development of postoperative apathy. Debate on the causes of postoperative apathy continues, and the dominant hypothesis is that stimulation or dopaminergic drug reductions are causal in its development. We hypothesized that a preoperative predisposition to apathy also could exist. To this end, we sought to identify a preoperative metabolic pattern using [(18) ]Fluorodeoxyglucose Positron Emission Tomography (PET), which could be associated with the occurrence of postoperative apathy after STN-DBS for PD.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26228098</PMID><DateCreated><Year>2015</Year><Month>7</Month><Day>31</Day></DateCreated><DateRevised><Year>2015</Year><Month>8</Month><Day>1</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year><Month>Jul</Month><Day>31</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>A preoperative metabolic marker of parkinsonian apathy following subthalamic nucleus stimulation.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.1002/mds.26349</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) has been associated with the development of postoperative apathy. Debate on the causes of postoperative apathy continues, and the dominant hypothesis is that stimulation or dopaminergic drug reductions are causal in its development. We hypothesized that a preoperative predisposition to apathy also could exist. To this end, we sought to identify a preoperative metabolic pattern using [(18) ]Fluorodeoxyglucose Positron Emission Tomography (PET), which could be associated with the occurrence of postoperative apathy after STN-DBS for PD.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Thirty-four patients with PD, not clinically apathetic, underwent an [(18) ]Fluorodeoxyglucose-PET scan before surgery of STN-DBS, and were tested for the occurrence of apathy 1 y after surgery. Whole-brain voxel-based PET intergroup comparison (P < 0.005; corrected for the cluster) was evaluated between patients who developed apathy at 1 y and those who did not.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Eight patients (23.5%) became apathetic after surgery. Motor improvement and decrease in dopaminergic treatment were similar in both postoperative apathy and non-apathy groups. We found a cluster of significantly greater metabolism in the postoperative apathy group within the cerebellum, brainstem (in particular ventral tegmental area), temporal lobe, insula, amygdala, lentiform nucleus, subgenual anterior cingulate, and inferior frontal gyrus. A metabolic value above 68 could discriminate patients who would develop postoperative apathy with 100% sensitivity and 88.5% specificity.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We describe a preoperative metabolic pattern associated with the development of apathy after STN-DBS in PD. This suggests the existence of a predisposition to apathy, which may further be triggered by perioperative drug modifications. © 2015 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList><Author><LastName>Gesquière-Dando</LastName><ForeName>Aude</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</Affiliation></AffiliationInfo></Author><Author><LastName>Guedj</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>APHM, CHU Timone, Service Central de Biophysique et Médecine Nucléaire, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CERIMED, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author><LastName>Loundou</LastName><ForeName>Anderson</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Unité d'Aide méthodologique à la Recherche Clinique et Epidémiologique, DRRC, Marseille, France.</Affiliation></AffiliationInfo></Author><Author><LastName>Carron</LastName><ForeName>Romain</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author><LastName>Witjas</LastName><ForeName>Tatiana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</Affiliation></AffiliationInfo></Author><Author><LastName>Fluchère</LastName><ForeName>Frédérique</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author><LastName>Delfini</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author><LastName>Mundler</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author><LastName>Regis</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author><LastName>Azulay</LastName><ForeName>Jean-Philippe</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</Affiliation></AffiliationInfo></Author><Author><LastName>Eusebio</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>7</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">FDG PET</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">apathy</Keyword><Keyword MajorTopicYN="N">predictive marker</Keyword><Keyword MajorTopicYN="N">subthalamic nucleus stimulation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>1</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>6</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>6</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId 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