Diffusion imaging of nigral alterations in early Parkinson's disease with dopaminergic deficits.
Identifieur interne : 000070 ( PubMed/Curation ); précédent : 000069; suivant : 000071Diffusion imaging of nigral alterations in early Parkinson's disease with dopaminergic deficits.
Auteurs : Norbert Schuff [États-Unis] ; I-Wei Wu [États-Unis] ; Shannon Buckley [États-Unis] ; Eric D. Foster [États-Unis] ; Christopher S. Coffey [États-Unis] ; Darren R. Gitelman [États-Unis] ; Susan Mendick [États-Unis] ; John Seibyl [États-Unis] ; Tanya Simuni [États-Unis] ; Yu Zhang [États-Unis] ; Joseph Jankovic [États-Unis] ; Christine Hunter [États-Unis] ; Caroline M. Tanner [États-Unis] ; Linda Rees [États-Unis] ; Stewart Factor [États-Unis] ; Daniela Berg [Allemagne] ; Isabel Wurster [Allemagne] ; Katharina Gauss [Allemagne] ; Fabienne Sprenger [Autriche] ; Klaus Seppi [Autriche] ; Werner Poewe [Autriche] ; Brit Mollenhauer [Allemagne] ; Susanne Knake [Allemagne] ; Zoltan Mari [États-Unis] ; Arita Mccoy [États-Unis] ; Madelaine Ranola [Australie] ; Kenneth Marek [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusion imaging values from the substantia nigra. in a large multicenter cohort and determine whether nigral diffusion alterations are associated with dopamine deficits.
DOI: 10.1002/mds.26325
PubMed: 26260437
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Foster</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa</wicri:regionArea></affiliation></author><author><name sortKey="Coffey, Christopher S" sort="Coffey, Christopher S" uniqKey="Coffey C" first="Christopher S" last="Coffey">Christopher S. Coffey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa</wicri:regionArea></affiliation></author><author><name sortKey="Gitelman, Darren R" sort="Gitelman, Darren R" uniqKey="Gitelman D" first="Darren R" last="Gitelman">Darren R. 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Tanner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veteran Affairs Medical Center, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veteran Affairs Medical Center, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Rees, Linda" sort="Rees, Linda" uniqKey="Rees L" first="Linda" last="Rees">Linda Rees</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of California, San Francisco, CA</wicri:regionArea></affiliation></author><author><name sortKey="Factor, Stewart" sort="Factor, Stewart" uniqKey="Factor S" first="Stewart" last="Factor">Stewart Factor</name><affiliation wicri:level="1"><nlm:affiliation>Emory University, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory University, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="1"><nlm:affiliation>University of Tuebingen, Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tuebingen, Tuebingen</wicri:regionArea></affiliation></author><author><name sortKey="Wurster, Isabel" sort="Wurster, Isabel" uniqKey="Wurster I" first="Isabel" last="Wurster">Isabel Wurster</name><affiliation wicri:level="1"><nlm:affiliation>University of Tuebingen, Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tuebingen, Tuebingen</wicri:regionArea></affiliation></author><author><name sortKey="Gauss, Katharina" sort="Gauss, Katharina" uniqKey="Gauss K" first="Katharina" last="Gauss">Katharina Gauss</name><affiliation wicri:level="1"><nlm:affiliation>University of Tuebingen, Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tuebingen, Tuebingen</wicri:regionArea></affiliation></author><author><name sortKey="Sprenger, Fabienne" sort="Sprenger, Fabienne" uniqKey="Sprenger F" first="Fabienne" last="Sprenger">Fabienne Sprenger</name><affiliation wicri:level="1"><nlm:affiliation>Innsbruck Medical University, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation wicri:level="1"><nlm:affiliation>Innsbruck Medical University, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><nlm:affiliation>Innsbruck Medical University, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><affiliation wicri:level="1"><nlm:affiliation>Paracelsus-Elena Klinik, Kassel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena Klinik, Kassel</wicri:regionArea></affiliation></author><author><name sortKey="Knake, Susanne" sort="Knake, Susanne" uniqKey="Knake S" first="Susanne" last="Knake">Susanne Knake</name><affiliation wicri:level="1"><nlm:affiliation>Paracelsus-Elena Klinik, Kassel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena Klinik, Kassel</wicri:regionArea></affiliation></author><author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name><affiliation wicri:level="1"><nlm:affiliation>Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Mccoy, Arita" sort="Mccoy, Arita" uniqKey="Mccoy A" first="Arita" last="Mccoy">Arita Mccoy</name><affiliation wicri:level="1"><nlm:affiliation>Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Ranola, Madelaine" sort="Ranola, Madelaine" uniqKey="Ranola M" first="Madelaine" last="Ranola">Madelaine Ranola</name><affiliation wicri:level="1"><nlm:affiliation>Macquarie University, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Macquarie University, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Marek, Kenneth" sort="Marek, Kenneth" uniqKey="Marek K" first="Kenneth" last="Marek">Kenneth Marek</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), New Haven, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), New Haven, Connecticut</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26260437</idno><idno type="pmid">26260437</idno><idno type="doi">10.1002/mds.26325</idno><idno type="wicri:Area/PubMed/Corpus">000070</idno><idno type="wicri:Area/PubMed/Curation">000070</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Diffusion imaging of nigral alterations in early Parkinson's disease with dopaminergic deficits.</title><author><name sortKey="Schuff, Norbert" sort="Schuff, Norbert" uniqKey="Schuff N" first="Norbert" last="Schuff">Norbert Schuff</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veteran Affairs Medical Center, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veteran Affairs Medical Center, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Wu, I Wei" sort="Wu, I Wei" uniqKey="Wu I" first="I-Wei" last="Wu">I-Wei Wu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veteran Affairs Medical Center, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veteran Affairs Medical Center, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Buckley, Shannon" sort="Buckley, Shannon" uniqKey="Buckley S" first="Shannon" last="Buckley">Shannon Buckley</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veteran Affairs Medical Center, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veteran Affairs Medical Center, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Foster, Eric D" sort="Foster, Eric D" uniqKey="Foster E" first="Eric D" last="Foster">Eric D. Foster</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa</wicri:regionArea></affiliation></author><author><name sortKey="Coffey, Christopher S" sort="Coffey, Christopher S" uniqKey="Coffey C" first="Christopher S" last="Coffey">Christopher S. Coffey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa</wicri:regionArea></affiliation></author><author><name sortKey="Gitelman, Darren R" sort="Gitelman, Darren R" uniqKey="Gitelman D" first="Darren R" last="Gitelman">Darren R. Gitelman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois</wicri:regionArea></affiliation></author><author><name sortKey="Mendick, Susan" sort="Mendick, Susan" uniqKey="Mendick S" first="Susan" last="Mendick">Susan Mendick</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), New Haven, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), New Haven, Connecticut</wicri:regionArea></affiliation></author><author><name sortKey="Seibyl, John" sort="Seibyl, John" uniqKey="Seibyl J" first="John" last="Seibyl">John Seibyl</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), New Haven, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), New Haven, Connecticut</wicri:regionArea></affiliation></author><author><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veteran Affairs Medical Center, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veteran Affairs Medical Center, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="1"><nlm:affiliation>Baylor College of Medicine, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name><affiliation wicri:level="1"><nlm:affiliation>Baylor College of Medicine, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veteran Affairs Medical Center, San Francisco, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veteran Affairs Medical Center, San Francisco, California</wicri:regionArea></affiliation></author><author><name sortKey="Rees, Linda" sort="Rees, Linda" uniqKey="Rees L" first="Linda" last="Rees">Linda Rees</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of California, San Francisco, CA</wicri:regionArea></affiliation></author><author><name sortKey="Factor, Stewart" sort="Factor, Stewart" uniqKey="Factor S" first="Stewart" last="Factor">Stewart Factor</name><affiliation wicri:level="1"><nlm:affiliation>Emory University, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory University, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="1"><nlm:affiliation>University of Tuebingen, Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tuebingen, Tuebingen</wicri:regionArea></affiliation></author><author><name sortKey="Wurster, Isabel" sort="Wurster, Isabel" uniqKey="Wurster I" first="Isabel" last="Wurster">Isabel Wurster</name><affiliation wicri:level="1"><nlm:affiliation>University of Tuebingen, Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tuebingen, Tuebingen</wicri:regionArea></affiliation></author><author><name sortKey="Gauss, Katharina" sort="Gauss, Katharina" uniqKey="Gauss K" first="Katharina" last="Gauss">Katharina Gauss</name><affiliation wicri:level="1"><nlm:affiliation>University of Tuebingen, Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tuebingen, Tuebingen</wicri:regionArea></affiliation></author><author><name sortKey="Sprenger, Fabienne" sort="Sprenger, Fabienne" uniqKey="Sprenger F" first="Fabienne" last="Sprenger">Fabienne Sprenger</name><affiliation wicri:level="1"><nlm:affiliation>Innsbruck Medical University, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation wicri:level="1"><nlm:affiliation>Innsbruck Medical University, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><nlm:affiliation>Innsbruck Medical University, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Innsbruck Medical University, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><affiliation wicri:level="1"><nlm:affiliation>Paracelsus-Elena Klinik, Kassel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena Klinik, Kassel</wicri:regionArea></affiliation></author><author><name sortKey="Knake, Susanne" sort="Knake, Susanne" uniqKey="Knake S" first="Susanne" last="Knake">Susanne Knake</name><affiliation wicri:level="1"><nlm:affiliation>Paracelsus-Elena Klinik, Kassel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena Klinik, Kassel</wicri:regionArea></affiliation></author><author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name><affiliation wicri:level="1"><nlm:affiliation>Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Mccoy, Arita" sort="Mccoy, Arita" uniqKey="Mccoy A" first="Arita" last="Mccoy">Arita Mccoy</name><affiliation wicri:level="1"><nlm:affiliation>Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Ranola, Madelaine" sort="Ranola, Madelaine" uniqKey="Ranola M" first="Madelaine" last="Ranola">Madelaine Ranola</name><affiliation wicri:level="1"><nlm:affiliation>Macquarie University, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Macquarie University, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Marek, Kenneth" sort="Marek, Kenneth" uniqKey="Marek K" first="Kenneth" last="Marek">Kenneth Marek</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), New Haven, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), New Haven, Connecticut</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusion imaging values from the substantia nigra. in a large multicenter cohort and determine whether nigral diffusion alterations are associated with dopamine deficits.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26260437</PMID><DateCreated><Year>2015</Year><Month>10</Month><Day>15</Day></DateCreated><DateRevised><Year>2015</Year><Month>10</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year><Month>Aug</Month><Day>11</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Diffusion imaging of nigral alterations in early Parkinson's disease with dopaminergic deficits.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.1002/mds.26325</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusion imaging values from the substantia nigra. in a large multicenter cohort and determine whether nigral diffusion alterations are associated with dopamine deficits.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Two hundred twenty subjects (PD = 153; control = 67) from 10 imaging sites were included. All subjects had a full neurological exam, a ((123) I)ioflupane dopamine transporter (DAT) single-photon emission computer tomography scan, and diffusion tensor imaging. Fractional anisotropy as well as radial and axial diffusivity was computed within multiple regions across the substantia nigra.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A repeated-measures analysis of variance found a marginally nonsignificant interaction between regional fractional anisotropy of the substantia nigra and disease status (P = 0.08), conflicting with an earlier study. However, a linear mixed model that included control regions in addition to the nigral regions revealed a significant interaction between regions and disease status (P = 0.002), implying a characteristic distribution of reduced fractional anisotropy across the substantia nigra in PD. Reduced fractional anisotropy in PD was also associated with diminished DAT binding ratios. Both axial and radial diffusivity were also abnormal in PD.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Although routine nigral measurements of fractional anisotropy are clinically not helpful, the findings in this study suggest that more-sophisticated diffusion imaging protocols should be used when exploring the clinical utility of this imaging modality. © 2015 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList><Author><LastName>Schuff</LastName><ForeName>Norbert</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Veteran Affairs Medical Center, San Francisco, California, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Wu</LastName><ForeName>I-Wei</ForeName><Initials>IW</Initials><AffiliationInfo><Affiliation>Department of Veteran Affairs Medical Center, San Francisco, California, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Buckley</LastName><ForeName>Shannon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Veteran Affairs Medical Center, San Francisco, California, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Foster</LastName><ForeName>Eric D</ForeName><Initials>ED</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Coffey</LastName><ForeName>Christopher S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Gitelman</LastName><ForeName>Darren R</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Mendick</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), New Haven, Connecticut, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Seibyl</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), New Haven, Connecticut, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Simuni</LastName><ForeName>Tanya</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Zhang</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Veteran Affairs Medical Center, San Francisco, California, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Jankovic</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Baylor College of Medicine, Houston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Hunter</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Baylor College of Medicine, Houston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Tanner</LastName><ForeName>Caroline M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Veteran Affairs Medical Center, San Francisco, California, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, University of California, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Rees</LastName><ForeName>Linda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of California, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Factor</LastName><ForeName>Stewart</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Emory University, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Berg</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University of Tuebingen, Tuebingen, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Wurster</LastName><ForeName>Isabel</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>University of Tuebingen, Tuebingen, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Gauss</LastName><ForeName>Katharina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>University of Tuebingen, Tuebingen, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Sprenger</LastName><ForeName>Fabienne</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author><LastName>Seppi</LastName><ForeName>Klaus</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author><LastName>Poewe</LastName><ForeName>Werner</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author><LastName>Mollenhauer</LastName><ForeName>Brit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Paracelsus-Elena Klinik, Kassel, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Knake</LastName><ForeName>Susanne</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Paracelsus-Elena Klinik, Kassel, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Mari</LastName><ForeName>Zoltan</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Johns Hopkins University, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>McCoy</LastName><ForeName>Arita</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Johns Hopkins University, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Ranola</LastName><ForeName>Madelaine</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Macquarie University, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author><LastName>Marek</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), New Haven, Connecticut, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>8</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">dopamine</Keyword><Keyword MajorTopicYN="N">fractional anisotropy</Keyword><Keyword MajorTopicYN="N">neuroimaging</Keyword><Keyword MajorTopicYN="N">substantia nigra</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>7</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>5</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>6</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26260437</ArticleId><ArticleId IdType="doi">10.1002/mds.26325</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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