The autonomic nervous system in Gilles de la Tourette's syndrome.
Identifieur interne : 005091 ( PubMed/Corpus ); précédent : 005090; suivant : 005092The autonomic nervous system in Gilles de la Tourette's syndrome.
Auteurs : C G Goetz ; K M Shannon ; V S Carroll ; C M Tanner ; R. WeingartenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1987.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antipsychotic Agents, Clonidine.
- drug effects : Autonomic Nervous System.
- drug therapy : Tourette Syndrome.
- physiopathology : Autonomic Nervous System, Tourette Syndrome.
- Adolescent, Adult, Drug Therapy, Combination, Female, Humans, Male.
Abstract
Twenty-three patients with Gilles de la Tourette's syndrome (GTS) underwent noninvasive investigation of autonomic nervous system (ANS) function, as did 23 age-matched controls. ANS function in GTS patients was no different from that of controls, and patients receiving neuroleptic drugs had the same ANS function as untreated patients. All 23 patients later received clonidine and were retested. The ANS values before administration of clonidine were compared with those while patients were taking clonidine. The only significant change (p less than 0.01) with clonidine was a reduced resting pulse rate. The combination of clonidine and neuroleptic drugs did not induce significant autonomic changes compared with neuroleptic therapy alone. These results indicate that the ANS in GTS patients is normal and that the drugs used to abate tics do not produce clinically significant changes in ANS when chronically given. The findings suggest that the pathophysiology and treatment of GTS do not directly involve the nuclei or tracts of autonomic regulation.
DOI: 10.1002/mds.870020203
PubMed: 2904121
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pubmed:2904121Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The autonomic nervous system in Gilles de la Tourette's syndrome.</title><author><name sortKey="Goetz, C G" sort="Goetz, C G" uniqKey="Goetz C" first="C G" last="Goetz">C G Goetz</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.</nlm:affiliation></affiliation></author><author><name sortKey="Shannon, K M" sort="Shannon, K M" uniqKey="Shannon K" first="K M" last="Shannon">K M Shannon</name></author><author><name sortKey="Carroll, V S" sort="Carroll, V S" uniqKey="Carroll V" first="V S" last="Carroll">V S Carroll</name></author><author><name sortKey="Tanner, C M" sort="Tanner, C M" uniqKey="Tanner C" first="C M" last="Tanner">C M Tanner</name></author><author><name sortKey="Weingarten, R" sort="Weingarten, R" uniqKey="Weingarten R" first="R" last="Weingarten">R. Weingarten</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1987">1987</date><idno type="RBID">pubmed:2904121</idno><idno type="pmid">2904121</idno><idno type="doi">10.1002/mds.870020203</idno><idno type="wicri:Area/PubMed/Corpus">005091</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The autonomic nervous system in Gilles de la Tourette's syndrome.</title><author><name sortKey="Goetz, C G" sort="Goetz, C G" uniqKey="Goetz C" first="C G" last="Goetz">C G Goetz</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.</nlm:affiliation></affiliation></author><author><name sortKey="Shannon, K M" sort="Shannon, K M" uniqKey="Shannon K" first="K M" last="Shannon">K M Shannon</name></author><author><name sortKey="Carroll, V S" sort="Carroll, V S" uniqKey="Carroll V" first="V S" last="Carroll">V S Carroll</name></author><author><name sortKey="Tanner, C M" sort="Tanner, C M" uniqKey="Tanner C" first="C M" last="Tanner">C M Tanner</name></author><author><name sortKey="Weingarten, R" sort="Weingarten, R" uniqKey="Weingarten R" first="R" last="Weingarten">R. Weingarten</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antipsychotic Agents (pharmacology)</term><term>Autonomic Nervous System (drug effects)</term><term>Autonomic Nervous System (physiopathology)</term><term>Clonidine (pharmacology)</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Tourette Syndrome (drug therapy)</term><term>Tourette Syndrome (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antipsychotic Agents</term><term>Clonidine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autonomic Nervous System</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Twenty-three patients with Gilles de la Tourette's syndrome (GTS) underwent noninvasive investigation of autonomic nervous system (ANS) function, as did 23 age-matched controls. ANS function in GTS patients was no different from that of controls, and patients receiving neuroleptic drugs had the same ANS function as untreated patients. All 23 patients later received clonidine and were retested. The ANS values before administration of clonidine were compared with those while patients were taking clonidine. The only significant change (p less than 0.01) with clonidine was a reduced resting pulse rate. The combination of clonidine and neuroleptic drugs did not induce significant autonomic changes compared with neuroleptic therapy alone. These results indicate that the ANS in GTS patients is normal and that the drugs used to abate tics do not produce clinically significant changes in ANS when chronically given. The findings suggest that the pathophysiology and treatment of GTS do not directly involve the nuclei or tracts of autonomic regulation.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">2904121</PMID><DateCreated><Year>1988</Year><Month>12</Month><Day>23</Day></DateCreated><DateCompleted><Year>1988</Year><Month>12</Month><Day>23</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>2</Volume><Issue>2</Issue><PubDate><Year>1987</Year></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>The autonomic nervous system in Gilles de la Tourette's syndrome.</ArticleTitle><Pagination><MedlinePgn>99-102</MedlinePgn></Pagination><Abstract><AbstractText>Twenty-three patients with Gilles de la Tourette's syndrome (GTS) underwent noninvasive investigation of autonomic nervous system (ANS) function, as did 23 age-matched controls. ANS function in GTS patients was no different from that of controls, and patients receiving neuroleptic drugs had the same ANS function as untreated patients. All 23 patients later received clonidine and were retested. The ANS values before administration of clonidine were compared with those while patients were taking clonidine. The only significant change (p less than 0.01) with clonidine was a reduced resting pulse rate. The combination of clonidine and neuroleptic drugs did not induce significant autonomic changes compared with neuroleptic therapy alone. These results indicate that the ANS in GTS patients is normal and that the drugs used to abate tics do not produce clinically significant changes in ANS when chronically given. The findings suggest that the pathophysiology and treatment of GTS do not directly involve the nuclei or tracts of autonomic regulation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Goetz</LastName><ForeName>C G</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shannon</LastName><ForeName>K M</ForeName><Initials>KM</Initials></Author><Author ValidYN="Y"><LastName>Carroll</LastName><ForeName>V S</ForeName><Initials>VS</Initials></Author><Author ValidYN="Y"><LastName>Tanner</LastName><ForeName>C M</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Weingarten</LastName><ForeName>R</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014150">Antipsychotic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>MN3L5RMN02</RegistryNumber><NameOfSubstance UI="D003000">Clonidine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000293">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014150">Antipsychotic Agents</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001341">Autonomic Nervous System</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003000">Clonidine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004359">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005879">Tourette Syndrome</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1987</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1987</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1987</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2904121</ArticleId><ArticleId IdType="doi">10.1002/mds.870020203</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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