MovDisordV3, PubMed, Corpus, bibRecord, 005064

Computed tomographic findings in progressive supranuclear palsy: correlation with clinical grade.

Identifieur interne : 005064 ( PubMed/Corpus ); précédent : 005063; suivant : 005065

Computed tomographic findings in progressive supranuclear palsy: correlation with clinical grade.

Auteurs : S M Schonfeld ; L I Golbe ; J I Sage ; J N Safer ; R C Duvoisin

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1987.

RBID : pubmed:3504554

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Atrophy, Brain (pathology), Brain (radiography), Cephalometry, Female, Humans, Male, Middle Aged, Supranuclear Palsy, Progressive (radiography), Tomography, X-Ray Computed.
MESH :
- pathology : Brain.
- radiography : Brain, Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Atrophy, Cephalometry, Female, Humans, Male, Middle Aged, Tomography, X-Ray Computed.

Abstract

We report clinical and computed tomography (CT) findings in 17 patients with progressive supranuclear palsy (PSP). Patients were divided into four clinical groups according to the severity of the disease and functional disability. In Grade 1, patients demonstrated minor disability and decreased anteroposterior (AP) diameter of the midbrain tegmentum was present. As the disease progressed clinically to Grade 2, more severe atrophy of the pons and midbrain and dilatation of the quadrigeminal plate cistern were noted. The most severe stages of clinical disability (Grades 3 and 4) were characterized radiologically by dilatation of the aqueduct, progressive dilatation of the third and fourth ventricles and atrophy of the temporal lobes. Cortical atrophy was variable and not a prominent radiological feature. Midbrain and pontine AP diameters were significantly smaller in PSP patients than normal patients. Serial studies showed progressive involution of the pons and midbrain and enlargement of the third ventricle. While the most obvious CT changes in PSP occur late in the disease, CT may in fact suggest the correct diagnosis long before the classic clinical picture is evident.

DOI: 10.1002/mds.870020404
PubMed: 3504554

Links to Exploration step

pubmed:3504554

Le document en format XML

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<author><name sortKey="Schonfeld, S M" sort="Schonfeld, S M" uniqKey="Schonfeld S" first="S M" last="Schonfeld">S M Schonfeld</name>
<affiliation><nlm:affiliation>Department of Radiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903.</nlm:affiliation>
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</author>
<author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L I" last="Golbe">L I Golbe</name>
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<author><name sortKey="Sage, J I" sort="Sage, J I" uniqKey="Sage J" first="J I" last="Sage">J I Sage</name>
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<author><name sortKey="Safer, J N" sort="Safer, J N" uniqKey="Safer J" first="J N" last="Safer">J N Safer</name>
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<author><name sortKey="Duvoisin, R C" sort="Duvoisin, R C" uniqKey="Duvoisin R" first="R C" last="Duvoisin">R C Duvoisin</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Computed tomographic findings in progressive supranuclear palsy: correlation with clinical grade.</title>
<author><name sortKey="Schonfeld, S M" sort="Schonfeld, S M" uniqKey="Schonfeld S" first="S M" last="Schonfeld">S M Schonfeld</name>
<affiliation><nlm:affiliation>Department of Radiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903.</nlm:affiliation>
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<author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L I" last="Golbe">L I Golbe</name>
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<author><name sortKey="Sage, J I" sort="Sage, J I" uniqKey="Sage J" first="J I" last="Sage">J I Sage</name>
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<author><name sortKey="Safer, J N" sort="Safer, J N" uniqKey="Safer J" first="J N" last="Safer">J N Safer</name>
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<author><name sortKey="Duvoisin, R C" sort="Duvoisin, R C" uniqKey="Duvoisin R" first="R C" last="Duvoisin">R C Duvoisin</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
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<term>Brain (pathology)</term>
<term>Brain (radiography)</term>
<term>Cephalometry</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Supranuclear Palsy, Progressive (radiography)</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" qualifier="radiography" xml:lang="en"><term>Brain</term>
<term>Supranuclear Palsy, Progressive</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Atrophy</term>
<term>Cephalometry</term>
<term>Female</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">We report clinical and computed tomography (CT) findings in 17 patients with progressive supranuclear palsy (PSP). Patients were divided into four clinical groups according to the severity of the disease and functional disability. In Grade 1, patients demonstrated minor disability and decreased anteroposterior (AP) diameter of the midbrain tegmentum was present. As the disease progressed clinically to Grade 2, more severe atrophy of the pons and midbrain and dilatation of the quadrigeminal plate cistern were noted. The most severe stages of clinical disability (Grades 3 and 4) were characterized radiologically by dilatation of the aqueduct, progressive dilatation of the third and fourth ventricles and atrophy of the temporal lobes. Cortical atrophy was variable and not a prominent radiological feature. Midbrain and pontine AP diameters were significantly smaller in PSP patients than normal patients. Serial studies showed progressive involution of the pons and midbrain and enlargement of the third ventricle. While the most obvious CT changes in PSP occur late in the disease, CT may in fact suggest the correct diagnosis long before the classic clinical picture is evident.</div>
</front>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<Abstract><AbstractText>We report clinical and computed tomography (CT) findings in 17 patients with progressive supranuclear palsy (PSP). Patients were divided into four clinical groups according to the severity of the disease and functional disability. In Grade 1, patients demonstrated minor disability and decreased anteroposterior (AP) diameter of the midbrain tegmentum was present. As the disease progressed clinically to Grade 2, more severe atrophy of the pons and midbrain and dilatation of the quadrigeminal plate cistern were noted. The most severe stages of clinical disability (Grades 3 and 4) were characterized radiologically by dilatation of the aqueduct, progressive dilatation of the third and fourth ventricles and atrophy of the temporal lobes. Cortical atrophy was variable and not a prominent radiological feature. Midbrain and pontine AP diameters were significantly smaller in PSP patients than normal patients. Serial studies showed progressive involution of the pons and midbrain and enlargement of the third ventricle. While the most obvious CT changes in PSP occur late in the disease, CT may in fact suggest the correct diagnosis long before the classic clinical picture is evident.</AbstractText>
</Abstract>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D002508">Cephalometry</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D013494">Supranuclear Palsy, Progressive</DescriptorName>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Computed tomographic findings in progressive supranuclear palsy: correlation with clinical grade.

Computed tomographic findings in progressive supranuclear palsy: correlation with clinical grade.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki