HLA antigens in drug-induced parkinsonism.
Identifieur interne : 004F94 ( PubMed/Corpus ); précédent : 004F93; suivant : 004F95HLA antigens in drug-induced parkinsonism.
Auteurs : W S Metzer ; J E Newton ; R W Steele ; M. Claybrook ; S R Paige ; D E Mcmillan ; S. HaysSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1989.
English descriptors
- KwdEn :
- Adult, Antipsychotic Agents (adverse effects), Antipsychotic Agents (therapeutic use), Dyskinesia, Drug-Induced (genetics), HLA Antigens (genetics), Humans, Male, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (genetics), Risk Factors, Schizophrenia (drug therapy), Schizophrenia (genetics).
- MESH :
- chemical , adverse effects : Antipsychotic Agents.
- chemical , genetics : HLA Antigens.
- chemical , therapeutic use : Antipsychotic Agents.
- chemically induced : Parkinson Disease, Secondary.
- drug therapy : Schizophrenia.
- genetics : Dyskinesia, Drug-Induced, Parkinson Disease, Secondary, Schizophrenia.
- Adult, Humans, Male, Risk Factors.
Abstract
The results of two epidemiological studies suggest a hereditary predisposition to develop drug-induced parkinsonism. We investigated human leukocyte antigen (HLA) antigen prevalence rates in patients with neuroleptic-induced parkinsonism. Fifty-two male, white, neuroleptic-treated, chronic in-patients with DSM-III-diagnosed schizophrenia were examined for the presence of parkinsonism. Subjects were tested for 23 type A, 43 type B, 4 type C, and 10 type DR HLA antigens. The group of schizophrenic patients with parkinsonism (n = 29) was compared with the group of schizophrenic patients without parkinsonism (n = 23). There were no significant differences between the two groups with respect to age, duration of neuroleptic exposure, or anticholinergic drug exposure. One HLA antigen, B44, was significantly more prevalent in the group with parkinsonism than in the group without parkinsonism. We derived a relative risk of 7.16 for drug-induced parkinsonism with HLA-B44 present in this group of schizophrenic patients. These data indicate that HLA-B44 may play a role in genetic or immunologic susceptibility to develop drug-induced parkinsonism in white schizophrenic individuals.
DOI: 10.1002/mds.870040203
PubMed: 2567491
Links to Exploration step
pubmed:2567491Le document en format XML
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<author><name sortKey="Metzer, W S" sort="Metzer, W S" uniqKey="Metzer W" first="W S" last="Metzer">W S Metzer</name>
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<author><name sortKey="Newton, J E" sort="Newton, J E" uniqKey="Newton J" first="J E" last="Newton">J E Newton</name>
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<author><name sortKey="Steele, R W" sort="Steele, R W" uniqKey="Steele R" first="R W" last="Steele">R W Steele</name>
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<author><name sortKey="Claybrook, M" sort="Claybrook, M" uniqKey="Claybrook M" first="M" last="Claybrook">M. Claybrook</name>
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<author><name sortKey="Paige, S R" sort="Paige, S R" uniqKey="Paige S" first="S R" last="Paige">S R Paige</name>
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<author><name sortKey="Mcmillan, D E" sort="Mcmillan, D E" uniqKey="Mcmillan D" first="D E" last="Mcmillan">D E Mcmillan</name>
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<author><name sortKey="Hays, S" sort="Hays, S" uniqKey="Hays S" first="S" last="Hays">S. Hays</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">HLA antigens in drug-induced parkinsonism.</title>
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<author><name sortKey="Steele, R W" sort="Steele, R W" uniqKey="Steele R" first="R W" last="Steele">R W Steele</name>
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<term>HLA Antigens (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Parkinson Disease, Secondary (genetics)</term>
<term>Risk Factors</term>
<term>Schizophrenia (drug therapy)</term>
<term>Schizophrenia (genetics)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antipsychotic Agents</term>
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<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Schizophrenia</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Parkinson Disease, Secondary</term>
<term>Schizophrenia</term>
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<front><div type="abstract" xml:lang="en">The results of two epidemiological studies suggest a hereditary predisposition to develop drug-induced parkinsonism. We investigated human leukocyte antigen (HLA) antigen prevalence rates in patients with neuroleptic-induced parkinsonism. Fifty-two male, white, neuroleptic-treated, chronic in-patients with DSM-III-diagnosed schizophrenia were examined for the presence of parkinsonism. Subjects were tested for 23 type A, 43 type B, 4 type C, and 10 type DR HLA antigens. The group of schizophrenic patients with parkinsonism (n = 29) was compared with the group of schizophrenic patients without parkinsonism (n = 23). There were no significant differences between the two groups with respect to age, duration of neuroleptic exposure, or anticholinergic drug exposure. One HLA antigen, B44, was significantly more prevalent in the group with parkinsonism than in the group without parkinsonism. We derived a relative risk of 7.16 for drug-induced parkinsonism with HLA-B44 present in this group of schizophrenic patients. These data indicate that HLA-B44 may play a role in genetic or immunologic susceptibility to develop drug-induced parkinsonism in white schizophrenic individuals.</div>
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<Abstract><AbstractText>The results of two epidemiological studies suggest a hereditary predisposition to develop drug-induced parkinsonism. We investigated human leukocyte antigen (HLA) antigen prevalence rates in patients with neuroleptic-induced parkinsonism. Fifty-two male, white, neuroleptic-treated, chronic in-patients with DSM-III-diagnosed schizophrenia were examined for the presence of parkinsonism. Subjects were tested for 23 type A, 43 type B, 4 type C, and 10 type DR HLA antigens. The group of schizophrenic patients with parkinsonism (n = 29) was compared with the group of schizophrenic patients without parkinsonism (n = 23). There were no significant differences between the two groups with respect to age, duration of neuroleptic exposure, or anticholinergic drug exposure. One HLA antigen, B44, was significantly more prevalent in the group with parkinsonism than in the group without parkinsonism. We derived a relative risk of 7.16 for drug-induced parkinsonism with HLA-B44 present in this group of schizophrenic patients. These data indicate that HLA-B44 may play a role in genetic or immunologic susceptibility to develop drug-induced parkinsonism in white schizophrenic individuals.</AbstractText>
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