Postneuroleptic laryngeal dyskinesias: a cause of upper airway obstructive syndrome improved by local injections of botulinum toxin.
Identifieur interne : 004C44 ( PubMed/Corpus ); précédent : 004C43; suivant : 004C45Postneuroleptic laryngeal dyskinesias: a cause of upper airway obstructive syndrome improved by local injections of botulinum toxin.
Auteurs : A. Fève ; B. Angelard ; G. Fénelon ; M. Logak ; A. Guillard ; J. Lacau Saint-GuilySource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1993.
English descriptors
- KwdEn :
- Airway Obstruction (chemically induced), Airway Obstruction (drug therapy), Botulinum Toxins (administration & dosage), Dyskinesia, Drug-Induced (drug therapy), Electromyography (drug effects), Flupenthixol (administration & dosage), Flupenthixol (adverse effects), Humans, Injections, Intramuscular, Laryngeal Diseases (chemically induced), Laryngeal Diseases (drug therapy), Laryngeal Muscles (drug effects), Male, Middle Aged, Neurologic Examination (drug effects), Spouse Abuse (prevention & control), Violence.
- MESH :
- chemical , administration & dosage : Botulinum Toxins, Flupenthixol.
- chemical , adverse effects : Flupenthixol.
- chemically induced : Airway Obstruction, Laryngeal Diseases.
- drug effects : Electromyography, Laryngeal Muscles, Neurologic Examination.
- drug therapy : Airway Obstruction, Dyskinesia, Drug-Induced, Laryngeal Diseases.
- prevention & control : Spouse Abuse.
- Humans, Injections, Intramuscular, Male, Middle Aged, Violence.
Abstract
We report a case of laryngeal dyskinesia resulting in severe rest and exercise dyspnea. A 51-year-old man treated for 2 years with flupentixol, an incisive neuroleptic, developed severe dyspnea due to intermittent, rhythmic, and dystonic movements of the vocal cords and upper airway. Local injections of botulinum toxin resulted in spectacular regression of laryngeal spasms and major improvement in breathing. This case emphasizes the risk of upper respiratory dyskinesias associated with neuroleptic treatment and shows the feasibility of a new local treatment in this life-threatening disorder.
DOI: 10.1002/mds.870080220
PubMed: 8474494
Links to Exploration step
pubmed:8474494Le document en format XML
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<author><name sortKey="Feve, A" sort="Feve, A" uniqKey="Feve A" first="A" last="Fève">A. Fève</name>
<affiliation><nlm:affiliation>Service de neurologie, Hôpital Tenon, Paris, France.</nlm:affiliation>
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<author><name sortKey="Angelard, B" sort="Angelard, B" uniqKey="Angelard B" first="B" last="Angelard">B. Angelard</name>
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<author><name sortKey="Fenelon, G" sort="Fenelon, G" uniqKey="Fenelon G" first="G" last="Fénelon">G. Fénelon</name>
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<author><name sortKey="Logak, M" sort="Logak, M" uniqKey="Logak M" first="M" last="Logak">M. Logak</name>
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<author><name sortKey="Guillard, A" sort="Guillard, A" uniqKey="Guillard A" first="A" last="Guillard">A. Guillard</name>
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<author><name sortKey="Lacau Saint Guily, J" sort="Lacau Saint Guily, J" uniqKey="Lacau Saint Guily J" first="J" last="Lacau Saint-Guily">J. Lacau Saint-Guily</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Postneuroleptic laryngeal dyskinesias: a cause of upper airway obstructive syndrome improved by local injections of botulinum toxin.</title>
<author><name sortKey="Feve, A" sort="Feve, A" uniqKey="Feve A" first="A" last="Fève">A. Fève</name>
<affiliation><nlm:affiliation>Service de neurologie, Hôpital Tenon, Paris, France.</nlm:affiliation>
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<author><name sortKey="Angelard, B" sort="Angelard, B" uniqKey="Angelard B" first="B" last="Angelard">B. Angelard</name>
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<author><name sortKey="Fenelon, G" sort="Fenelon, G" uniqKey="Fenelon G" first="G" last="Fénelon">G. Fénelon</name>
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<author><name sortKey="Logak, M" sort="Logak, M" uniqKey="Logak M" first="M" last="Logak">M. Logak</name>
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<author><name sortKey="Guillard, A" sort="Guillard, A" uniqKey="Guillard A" first="A" last="Guillard">A. Guillard</name>
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<author><name sortKey="Lacau Saint Guily, J" sort="Lacau Saint Guily, J" uniqKey="Lacau Saint Guily J" first="J" last="Lacau Saint-Guily">J. Lacau Saint-Guily</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="1993" type="published">1993</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Airway Obstruction (chemically induced)</term>
<term>Airway Obstruction (drug therapy)</term>
<term>Botulinum Toxins (administration & dosage)</term>
<term>Dyskinesia, Drug-Induced (drug therapy)</term>
<term>Electromyography (drug effects)</term>
<term>Flupenthixol (administration & dosage)</term>
<term>Flupenthixol (adverse effects)</term>
<term>Humans</term>
<term>Injections, Intramuscular</term>
<term>Laryngeal Diseases (chemically induced)</term>
<term>Laryngeal Diseases (drug therapy)</term>
<term>Laryngeal Muscles (drug effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurologic Examination (drug effects)</term>
<term>Spouse Abuse (prevention & control)</term>
<term>Violence</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Botulinum Toxins</term>
<term>Flupenthixol</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Flupenthixol</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Airway Obstruction</term>
<term>Laryngeal Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Electromyography</term>
<term>Laryngeal Muscles</term>
<term>Neurologic Examination</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Airway Obstruction</term>
<term>Dyskinesia, Drug-Induced</term>
<term>Laryngeal Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Spouse Abuse</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Injections, Intramuscular</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Violence</term>
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<front><div type="abstract" xml:lang="en">We report a case of laryngeal dyskinesia resulting in severe rest and exercise dyspnea. A 51-year-old man treated for 2 years with flupentixol, an incisive neuroleptic, developed severe dyspnea due to intermittent, rhythmic, and dystonic movements of the vocal cords and upper airway. Local injections of botulinum toxin resulted in spectacular regression of laryngeal spasms and major improvement in breathing. This case emphasizes the risk of upper respiratory dyskinesias associated with neuroleptic treatment and shows the feasibility of a new local treatment in this life-threatening disorder.</div>
</front>
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<Month>11</Month>
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<JournalIssue CitedMedium="Print"><Volume>8</Volume>
<Issue>2</Issue>
<PubDate><Year>1993</Year>
<Month>Apr</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Postneuroleptic laryngeal dyskinesias: a cause of upper airway obstructive syndrome improved by local injections of botulinum toxin.</ArticleTitle>
<Pagination><MedlinePgn>217-9</MedlinePgn>
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<Abstract><AbstractText>We report a case of laryngeal dyskinesia resulting in severe rest and exercise dyspnea. A 51-year-old man treated for 2 years with flupentixol, an incisive neuroleptic, developed severe dyspnea due to intermittent, rhythmic, and dystonic movements of the vocal cords and upper airway. Local injections of botulinum toxin resulted in spectacular regression of laryngeal spasms and major improvement in breathing. This case emphasizes the risk of upper respiratory dyskinesias associated with neuroleptic treatment and shows the feasibility of a new local treatment in this life-threatening disorder.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fève</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Service de neurologie, Hôpital Tenon, Paris, France.</Affiliation>
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<MedlineJournalInfo><Country>UNITED STATES</Country>
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<ChemicalList><Chemical><RegistryNumber>EC 3.4.24.69</RegistryNumber>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D013179">Spouse Abuse</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D014754">Violence</DescriptorName>
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