Evidence of cortical metabolic dysfunction in early Huntington's disease by single-photon-emission computed tomography.
Identifieur interne : 004761 ( PubMed/Corpus ); précédent : 004760; suivant : 004762Evidence of cortical metabolic dysfunction in early Huntington's disease by single-photon-emission computed tomography.
Auteurs : D S Sax ; R. Powsner ; A. Kim ; S. Tilak ; R. Bhatia ; L A Cupples ; R H MyersSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1996.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Basal Ganglia (blood supply), Basal Ganglia (radionuclide imaging), Brain Mapping, Cerebral Cortex (blood supply), Cerebral Cortex (radionuclide imaging), Energy Metabolism (physiology), Female, Humans, Huntington Disease (physiopathology), Huntington Disease (radionuclide imaging), Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Reference Values, Regional Blood Flow (physiology), Tomography, Emission-Computed, Single-Photon.
- MESH :
- blood supply : Basal Ganglia, Cerebral Cortex.
- physiology : Energy Metabolism, Regional Blood Flow.
- physiopathology : Huntington Disease.
- radionuclide imaging : Basal Ganglia, Cerebral Cortex, Huntington Disease.
- Adult, Aged, Aged, 80 and over, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Reference Values, Tomography, Emission-Computed, Single-Photon.
Abstract
We compared perfusion of prefrontal, motor, and sensory cortices and basal ganglia in 29 Huntington's disease (HD) patients and nine controls. We found a significant reduction in perfusion in patients with HD of short (< 6 years, n = 10), medium (6-10 years, n = 8), and long duration (> 10 years, n = 11) compared with controls. Among short-duration patients, we observed decreases in cortical perfusion before evidence of atrophy on magnetic resonance imaging, suggesting that decreases in neuronal activity, as reflected by perfusion levels, precede gross structural changes. As expected, decreased perfusion was marked in basal ganglia. The extent of cortical perfusion correlated with clinical assessments of functional capabilities as well as with the duration of disease. Prefrontal perfusion correlated with cognitive measures, and motor cortical perfusion correlated with physical disability and activities of daily living scores. We found no significant clinical correlations with sensory cortical perfusion. Single-photon-emission computed tomography may be a sensitive method for assessing disease progression in clinical trials and pharmacologic intervention.
DOI: 10.1002/mds.870110612
PubMed: 8914093
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pubmed:8914093Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evidence of cortical metabolic dysfunction in early Huntington's disease by single-photon-emission computed tomography.</title><author><name sortKey="Sax, D S" sort="Sax, D S" uniqKey="Sax D" first="D S" last="Sax">D S Sax</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Massachusetts 02118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Powsner, R" sort="Powsner, R" uniqKey="Powsner R" first="R" last="Powsner">R. Powsner</name></author><author><name sortKey="Kim, A" sort="Kim, A" uniqKey="Kim A" first="A" last="Kim">A. Kim</name></author><author><name sortKey="Tilak, S" sort="Tilak, S" uniqKey="Tilak S" first="S" last="Tilak">S. Tilak</name></author><author><name sortKey="Bhatia, R" sort="Bhatia, R" uniqKey="Bhatia R" first="R" last="Bhatia">R. Bhatia</name></author><author><name sortKey="Cupples, L A" sort="Cupples, L A" uniqKey="Cupples L" first="L A" last="Cupples">L A Cupples</name></author><author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R H" last="Myers">R H Myers</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1996">1996</date><idno type="RBID">pubmed:8914093</idno><idno type="pmid">8914093</idno><idno type="doi">10.1002/mds.870110612</idno><idno type="wicri:Area/PubMed/Corpus">004761</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evidence of cortical metabolic dysfunction in early Huntington's disease by single-photon-emission computed tomography.</title><author><name sortKey="Sax, D S" sort="Sax, D S" uniqKey="Sax D" first="D S" last="Sax">D S Sax</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Massachusetts 02118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Powsner, R" sort="Powsner, R" uniqKey="Powsner R" first="R" last="Powsner">R. Powsner</name></author><author><name sortKey="Kim, A" sort="Kim, A" uniqKey="Kim A" first="A" last="Kim">A. Kim</name></author><author><name sortKey="Tilak, S" sort="Tilak, S" uniqKey="Tilak S" first="S" last="Tilak">S. Tilak</name></author><author><name sortKey="Bhatia, R" sort="Bhatia, R" uniqKey="Bhatia R" first="R" last="Bhatia">R. Bhatia</name></author><author><name sortKey="Cupples, L A" sort="Cupples, L A" uniqKey="Cupples L" first="L A" last="Cupples">L A Cupples</name></author><author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R H" last="Myers">R H Myers</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Basal Ganglia (blood supply)</term><term>Basal Ganglia (radionuclide imaging)</term><term>Brain Mapping</term><term>Cerebral Cortex (blood supply)</term><term>Cerebral Cortex (radionuclide imaging)</term><term>Energy Metabolism (physiology)</term><term>Female</term><term>Humans</term><term>Huntington Disease (physiopathology)</term><term>Huntington Disease (radionuclide imaging)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Reference Values</term><term>Regional Blood Flow (physiology)</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Basal Ganglia</term><term>Cerebral Cortex</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Energy Metabolism</term><term>Regional Blood Flow</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Basal Ganglia</term><term>Cerebral Cortex</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Reference Values</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared perfusion of prefrontal, motor, and sensory cortices and basal ganglia in 29 Huntington's disease (HD) patients and nine controls. We found a significant reduction in perfusion in patients with HD of short (< 6 years, n = 10), medium (6-10 years, n = 8), and long duration (> 10 years, n = 11) compared with controls. Among short-duration patients, we observed decreases in cortical perfusion before evidence of atrophy on magnetic resonance imaging, suggesting that decreases in neuronal activity, as reflected by perfusion levels, precede gross structural changes. As expected, decreased perfusion was marked in basal ganglia. The extent of cortical perfusion correlated with clinical assessments of functional capabilities as well as with the duration of disease. Prefrontal perfusion correlated with cognitive measures, and motor cortical perfusion correlated with physical disability and activities of daily living scores. We found no significant clinical correlations with sensory cortical perfusion. Single-photon-emission computed tomography may be a sensitive method for assessing disease progression in clinical trials and pharmacologic intervention.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">8914093</PMID><DateCreated><Year>1997</Year><Month>03</Month><Day>20</Day></DateCreated><DateCompleted><Year>1997</Year><Month>03</Month><Day>20</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><Issue>6</Issue><PubDate><Year>1996</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Evidence of cortical metabolic dysfunction in early Huntington's disease by single-photon-emission computed tomography.</ArticleTitle><Pagination><MedlinePgn>671-7</MedlinePgn></Pagination><Abstract><AbstractText>We compared perfusion of prefrontal, motor, and sensory cortices and basal ganglia in 29 Huntington's disease (HD) patients and nine controls. We found a significant reduction in perfusion in patients with HD of short (< 6 years, n = 10), medium (6-10 years, n = 8), and long duration (> 10 years, n = 11) compared with controls. Among short-duration patients, we observed decreases in cortical perfusion before evidence of atrophy on magnetic resonance imaging, suggesting that decreases in neuronal activity, as reflected by perfusion levels, precede gross structural changes. As expected, decreased perfusion was marked in basal ganglia. The extent of cortical perfusion correlated with clinical assessments of functional capabilities as well as with the duration of disease. Prefrontal perfusion correlated with cognitive measures, and motor cortical perfusion correlated with physical disability and activities of daily living scores. We found no significant clinical correlations with sensory cortical perfusion. Single-photon-emission computed tomography may be a sensitive method for assessing disease progression in clinical trials and pharmacologic intervention.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sax</LastName><ForeName>D S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Massachusetts 02118, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Powsner</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Tilak</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Bhatia</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Cupples</LastName><ForeName>L A</ForeName><Initials>LA</Initials></Author><Author ValidYN="Y"><LastName>Myers</LastName><ForeName>R H</ForeName><Initials>RH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001479">Basal Ganglia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000098">blood supply</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001931">Brain Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002540">Cerebral Cortex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000098">blood supply</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004734">Energy Metabolism</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006816">Huntington Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012016">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012039">Regional Blood Flow</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D015899">Tomography, Emission-Computed, Single-Photon</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1996</Year><Month>11</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1996</Year><Month>11</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1996</Year><Month>11</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8914093</ArticleId><ArticleId IdType="doi">10.1002/mds.870110612</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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