MovDisordV3, PubMed, Corpus, bibRecord, 004288

Apomorphine induces changes in GPi spontaneous outflow in patients with Parkinson's disease.

Identifieur interne : 004288 ( PubMed/Corpus ); précédent : 004287; suivant : 004289

Apomorphine induces changes in GPi spontaneous outflow in patients with Parkinson's disease.

Auteurs : M. Merello ; J. Balej ; M. Delfino ; A. Cammarota ; O. Betti ; R. Leiguarda

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1999.

RBID : pubmed:9918343

English descriptors

KwdEn :
- Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Apomorphine (administration & dosage), Apomorphine (adverse effects), Electroencephalography (drug effects), Evoked Potentials (drug effects), Female, Globus Pallidus (drug effects), Globus Pallidus (physiopathology), Globus Pallidus (surgery), Humans, Male, Microelectrodes, Middle Aged, Neurologic Examination (drug effects), Neurons (drug effects), Neurons (physiology), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Signal Processing, Computer-Assisted, Synaptic Transmission (drug effects), Synaptic Transmission (physiology).
MESH :
- chemical , administration & dosage : Antiparkinson Agents, Apomorphine.
- chemical , adverse effects : Antiparkinson Agents, Apomorphine.
- drug effects : Electroencephalography, Evoked Potentials, Globus Pallidus, Neurologic Examination, Neurons, Synaptic Transmission.
- drug therapy : Parkinson Disease.
- physiology : Neurons, Synaptic Transmission.
- physiopathology : Globus Pallidus, Parkinson Disease.
- surgery : Globus Pallidus, Parkinson Disease.
- Female, Humans, Male, Microelectrodes, Middle Aged, Signal Processing, Computer-Assisted.

Abstract

To determine the effect of a single dose of apomorphine on internal globus pallidus (GPi) neuronal discharge in patients with Parkinson's disease (PD).

PubMed: 9918343

Links to Exploration step

pubmed:9918343

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Apomorphine induces changes in GPi spontaneous outflow in patients with Parkinson's disease.</title>
<author><name sortKey="Merello, M" sort="Merello, M" uniqKey="Merello M" first="M" last="Merello">M. Merello</name>
<affiliation><nlm:affiliation>Movement Disorders Section, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Balej, J" sort="Balej, J" uniqKey="Balej J" first="J" last="Balej">J. Balej</name>
</author>
<author><name sortKey="Delfino, M" sort="Delfino, M" uniqKey="Delfino M" first="M" last="Delfino">M. Delfino</name>
</author>
<author><name sortKey="Cammarota, A" sort="Cammarota, A" uniqKey="Cammarota A" first="A" last="Cammarota">A. Cammarota</name>
</author>
<author><name sortKey="Betti, O" sort="Betti, O" uniqKey="Betti O" first="O" last="Betti">O. Betti</name>
</author>
<author><name sortKey="Leiguarda, R" sort="Leiguarda, R" uniqKey="Leiguarda R" first="R" last="Leiguarda">R. Leiguarda</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1999">1999</date>
<idno type="RBID">pubmed:9918343</idno>
<idno type="pmid">9918343</idno>
<idno type="wicri:Area/PubMed/Corpus">004288</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Apomorphine induces changes in GPi spontaneous outflow in patients with Parkinson's disease.</title>
<author><name sortKey="Merello, M" sort="Merello, M" uniqKey="Merello M" first="M" last="Merello">M. Merello</name>
<affiliation><nlm:affiliation>Movement Disorders Section, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Balej, J" sort="Balej, J" uniqKey="Balej J" first="J" last="Balej">J. Balej</name>
</author>
<author><name sortKey="Delfino, M" sort="Delfino, M" uniqKey="Delfino M" first="M" last="Delfino">M. Delfino</name>
</author>
<author><name sortKey="Cammarota, A" sort="Cammarota, A" uniqKey="Cammarota A" first="A" last="Cammarota">A. Cammarota</name>
</author>
<author><name sortKey="Betti, O" sort="Betti, O" uniqKey="Betti O" first="O" last="Betti">O. Betti</name>
</author>
<author><name sortKey="Leiguarda, R" sort="Leiguarda, R" uniqKey="Leiguarda R" first="R" last="Leiguarda">R. Leiguarda</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="1999" type="published">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (administration & dosage)</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Apomorphine (administration & dosage)</term>
<term>Apomorphine (adverse effects)</term>
<term>Electroencephalography (drug effects)</term>
<term>Evoked Potentials (drug effects)</term>
<term>Female</term>
<term>Globus Pallidus (drug effects)</term>
<term>Globus Pallidus (physiopathology)</term>
<term>Globus Pallidus (surgery)</term>
<term>Humans</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
<term>Neurologic Examination (drug effects)</term>
<term>Neurons (drug effects)</term>
<term>Neurons (physiology)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Signal Processing, Computer-Assisted</term>
<term>Synaptic Transmission (drug effects)</term>
<term>Synaptic Transmission (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Electroencephalography</term>
<term>Evoked Potentials</term>
<term>Globus Pallidus</term>
<term>Neurologic Examination</term>
<term>Neurons</term>
<term>Synaptic Transmission</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term>
<term>Synaptic Transmission</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Globus Pallidus</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
<term>Signal Processing, Computer-Assisted</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To determine the effect of a single dose of apomorphine on internal globus pallidus (GPi) neuronal discharge in patients with Parkinson's disease (PD).</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">9918343</PMID>
<DateCreated><Year>1999</Year>
<Month>04</Month>
<Day>01</Day>
</DateCreated>
<DateCompleted><Year>1999</Year>
<Month>04</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN>
<JournalIssue CitedMedium="Print"><Volume>14</Volume>
<Issue>1</Issue>
<PubDate><Year>1999</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Apomorphine induces changes in GPi spontaneous outflow in patients with Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>45-9</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine the effect of a single dose of apomorphine on internal globus pallidus (GPi) neuronal discharge in patients with Parkinson's disease (PD).</AbstractText>
<AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Nine PD patients who underwent microelectrode-guided posteroventral pallidotomy (PVP) were studied. After identification of a single GPi unit discharge with sufficient spike S/N ratio to allow reliable thresholding, basal recording was followed by a single 3-mg subcutaneous injection. One-minute samples were recorded 10', 30', and 60' after apomorphine.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In four patients, recording was lost after 5-10 minutes. In two, changes were observed at peak-of-dose but recording was then lost, whereas three completed recording and returned to baseline, all five showing significant reduction in GPi firing rate (mean +/- standard deviation for basal and post-apomorphine were 143+/-55.6 and 52+/-19.2, respectively; p <0.002).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In patients with PD, apomorphine induces changes in GPi spontaneous discharge and modifies firing rates resembling recordings in normal primates. These findings show that clinical improvement as well as induction of dyskinesias following DA administration could be mediated by reduction of GPi outflow.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Merello</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Movement Disorders Section, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Balej</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Delfino</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cammarota</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Betti</LastName>
<ForeName>O</ForeName>
<Initials>O</Initials>
</Author>
<Author ValidYN="Y"><LastName>Leiguarda</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>UNITED STATES</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>N21FAR7B4S</RegistryNumber>
<NameOfSubstance UI="D001058">Apomorphine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000978">Antiparkinson Agents</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000008">administration & dosage</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001058">Apomorphine</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000008">administration & dosage</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D004569">Electroencephalography</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005071">Evoked Potentials</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005917">Globus Pallidus</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000601">surgery</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008839">Microelectrodes</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009474">Neurons</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000601">surgery</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012815">Signal Processing, Computer-Assisted</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009435">Synaptic Transmission</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year>
<Month>1</Month>
<Day>26</Day>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">9918343</ArticleId>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Apomorphine induces changes in GPi spontaneous outflow in patients with Parkinson's disease.

Apomorphine induces changes in GPi spontaneous outflow in patients with Parkinson's disease.

Source :

English descriptors

Abstract

Links to Exploration step

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