Clinical problems in non-fluctuating patients with Parkinson's disease: a community-based study.
Identifieur interne : 003F19 ( PubMed/Corpus ); précédent : 003F18; suivant : 003F20Clinical problems in non-fluctuating patients with Parkinson's disease: a community-based study.
Auteurs : J P Larsen ; K. Karlsen ; E. TandbergSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2000.
English descriptors
- KwdEn :
- Age of Onset, Aged, Antiparkinson Agents (adverse effects), Case-Control Studies, Dementia (epidemiology), Dementia (etiology), Depression (epidemiology), Depression (etiology), Diabetes Mellitus (epidemiology), Drug Tolerance, Fatigue (epidemiology), Fatigue (etiology), Female, Humans, Levodopa (adverse effects), Male, Movement Disorders (epidemiology), Movement Disorders (etiology), Neurologic Examination, Norway (epidemiology), Outpatients, Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Prevalence, Psychomotor Performance, Quality of Life, Questionnaires, Severity of Illness Index, Sleep Disorders (epidemiology), Sleep Disorders (etiology).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- geographic , epidemiology : Norway.
- complications : Parkinson Disease.
- epidemiology : Dementia, Depression, Diabetes Mellitus, Fatigue, Movement Disorders, Parkinson Disease, Sleep Disorders.
- etiology : Dementia, Depression, Fatigue, Movement Disorders, Sleep Disorders.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- Age of Onset, Aged, Case-Control Studies, Drug Tolerance, Female, Humans, Male, Neurologic Examination, Outpatients, Prevalence, Psychomotor Performance, Quality of Life, Questionnaires, Severity of Illness Index.
Abstract
To investigate the frequency of nonfluctuators in a community-based prevalence study of Parkinson's disease (PD) and to describe disability, non-motor problems, and health-related quality of life in patients with PD with and without motor fluctuations, and compare the findings to those of two control groups.
PubMed: 11009186
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pubmed:11009186Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical problems in non-fluctuating patients with Parkinson's disease: a community-based study.</title><author><name sortKey="Larsen, J P" sort="Larsen, J P" uniqKey="Larsen J" first="J P" last="Larsen">J P Larsen</name><affiliation><nlm:affiliation>Department of Neurology, Central Hospital of Rogaland, Stavanger, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Karlsen, K" sort="Karlsen, K" uniqKey="Karlsen K" first="K" last="Karlsen">K. Karlsen</name></author><author><name sortKey="Tandberg, E" sort="Tandberg, E" uniqKey="Tandberg E" first="E" last="Tandberg">E. Tandberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:11009186</idno><idno type="pmid">11009186</idno><idno type="wicri:Area/PubMed/Corpus">003F19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical problems in non-fluctuating patients with Parkinson's disease: a community-based study.</title><author><name sortKey="Larsen, J P" sort="Larsen, J P" uniqKey="Larsen J" first="J P" last="Larsen">J P Larsen</name><affiliation><nlm:affiliation>Department of Neurology, Central Hospital of Rogaland, Stavanger, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Karlsen, K" sort="Karlsen, K" uniqKey="Karlsen K" first="K" last="Karlsen">K. Karlsen</name></author><author><name sortKey="Tandberg, E" sort="Tandberg, E" uniqKey="Tandberg E" first="E" last="Tandberg">E. Tandberg</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Antiparkinson Agents (adverse effects)</term><term>Case-Control Studies</term><term>Dementia (epidemiology)</term><term>Dementia (etiology)</term><term>Depression (epidemiology)</term><term>Depression (etiology)</term><term>Diabetes Mellitus (epidemiology)</term><term>Drug Tolerance</term><term>Fatigue (epidemiology)</term><term>Fatigue (etiology)</term><term>Female</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Movement Disorders (epidemiology)</term><term>Movement Disorders (etiology)</term><term>Neurologic Examination</term><term>Norway (epidemiology)</term><term>Outpatients</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Prevalence</term><term>Psychomotor Performance</term><term>Quality of Life</term><term>Questionnaires</term><term>Severity of Illness Index</term><term>Sleep Disorders (epidemiology)</term><term>Sleep Disorders (etiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Norway</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dementia</term><term>Depression</term><term>Diabetes Mellitus</term><term>Fatigue</term><term>Movement Disorders</term><term>Parkinson Disease</term><term>Sleep Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dementia</term><term>Depression</term><term>Fatigue</term><term>Movement Disorders</term><term>Sleep Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Case-Control Studies</term><term>Drug Tolerance</term><term>Female</term><term>Humans</term><term>Male</term><term>Neurologic Examination</term><term>Outpatients</term><term>Prevalence</term><term>Psychomotor Performance</term><term>Quality of Life</term><term>Questionnaires</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the frequency of nonfluctuators in a community-based prevalence study of Parkinson's disease (PD) and to describe disability, non-motor problems, and health-related quality of life in patients with PD with and without motor fluctuations, and compare the findings to those of two control groups.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">11009186</PMID><DateCreated><Year>2001</Year><Month>01</Month><Day>09</Day></DateCreated><DateCompleted><Year>2001</Year><Month>01</Month><Day>09</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>15</Volume><Issue>5</Issue><PubDate><Year>2000</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Clinical problems in non-fluctuating patients with Parkinson's disease: a community-based study.</ArticleTitle><Pagination><MedlinePgn>826-9</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the frequency of nonfluctuators in a community-based prevalence study of Parkinson's disease (PD) and to describe disability, non-motor problems, and health-related quality of life in patients with PD with and without motor fluctuations, and compare the findings to those of two control groups.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The study involved 245 patients with PD who were participating in a prevalence study and two control groups (100 healthy elderly individuals and 100 patients with diabetes mellitus [DM]). Data were obtained through neurologic examination and a semistructured interview, and by the use of several questionnaires.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In this group of unselected patients with PD, 78% did not experience motor fluctuations. Mean duration of treatment with levodopa was 6.3 years. Patients with motor fluctuations had a lower age at onset of disease, longer duration of disease, and a higher daily levodopa dose than patients without fluctuations. Among the non-fluctuating patients, we found more dementia and a higher age at prevalence day. Disability (assessed by the Unified Parkinson's Disease Rating Scale subscales for activities of daily living and motor function and the Hoehn and Yahr stage) was similar in fluctuators and nonfluctuators. Depression, sleep disturbances, and fatigue were equally frequent in both patient groups. The occurrence of these difficulties was clearly more frequent among non-fluctuating patients with PD than among the control subjects.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Most patients in the general population who have PD do not experience dose-dependent motor fluctuations. Severity of motor disability and neuropsychiatric manifestations are as important in non-fluctuators as in fluctuators. Patients without motor fluctuations have more depression, sleep disturbances, fatigue, and a poorer health-related quality of life than patients with DM and healthy elderly individuals. This also underlines the importance of developing better management and treatment strategies for this group of patients with PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Larsen</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Neurology, Central Hospital of Rogaland, Stavanger, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karlsen</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Tandberg</LastName><ForeName>E</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017668">Age of Onset</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000978">Antiparkinson Agents</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016022">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003704">Dementia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003863">Depression</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003920">Diabetes Mellitus</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004361">Drug Tolerance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005221">Fatigue</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007980">Levodopa</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009069">Movement Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D009664">Norway</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010045">Outpatients</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015995">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D011597">Psychomotor Performance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D011788">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" 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