Parkinson's disease is associated with hippocampal atrophy.
Identifieur interne : 003753 ( PubMed/Corpus ); précédent : 003752; suivant : 003754Parkinson's disease is associated with hippocampal atrophy.
Auteurs : Richard Camicioli ; M Milar Moore ; Anthony Kinney ; Elizabeth Corbridge ; Kathryn Glassberg ; Jeffrey A. KayeSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Aged, Alzheimer Disease (diagnosis), Atrophy, Brain (pathology), Cerebral Cortex (pathology), Dementia (diagnosis), Diagnosis, Differential, Disease Progression, Female, Hippocampus (pathology), Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mathematical Computing, Neurologic Examination, Neuropsychological Tests, Parahippocampal Gyrus (pathology), Parkinson Disease (diagnosis), Red Nucleus (pathology), Reference Values, Superior Colliculi (pathology).
- MESH :
- diagnosis : Alzheimer Disease, Dementia, Parkinson Disease.
- pathology : Brain, Cerebral Cortex, Hippocampus, Parahippocampal Gyrus, Red Nucleus, Superior Colliculi.
- Aged, Atrophy, Diagnosis, Differential, Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mathematical Computing, Neurologic Examination, Neuropsychological Tests, Reference Values.
Abstract
Patients with Parkinson's disease (PD) may have hippocampal atrophy compared with controls. We compared hippocampal, and extra-hippocampal volumes between PD, PDD (patients with PD who have mild cognitive impairment or dementia), Alzheimer's disease (AD) and controls using volumetric magnetic resonance imaging (MRI). Participants (10 patients with PD, 10 with PDD, 11 with AD, and 12 control subjects) had an informant interview, neurological examination, and psychometric testing. Established, reliable methods were used to measure the hippocampus, parahippocampal gyrus, temporal, frontal, and parieto-occipital lobes. Correction for intracranial volume was carried out before comparison. There was no age difference between groups (mean age, 74 years). On the Clinical Dementia Rating scale (CDR) cognitive impairment was mild (CDR = 0.5) in the majority of PDD and AD patients. Hippocampal (P < 0.0004) volumes were smaller in the patient groups. Effect sizes compared with the control group were: PD, 0.66; PDD, 1.22; and AD, 1.81. The other volumes did not differ significantly. Among PD and PDD patients, recognition memory (r = 0.54, P = 0.015) and Mini-Mental State Examination scores (r = 0.56, P = 0.01) correlated with left, but not right hippocampal volume. In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early marker for dementia in PD.
DOI: 10.1002/mds.10444
PubMed: 12815657
Links to Exploration step
pubmed:12815657Le document en format XML
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<author><name sortKey="Moore, M Milar" sort="Moore, M Milar" uniqKey="Moore M" first="M Milar" last="Moore">M Milar Moore</name>
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<author><name sortKey="Kinney, Anthony" sort="Kinney, Anthony" uniqKey="Kinney A" first="Anthony" last="Kinney">Anthony Kinney</name>
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<author><name sortKey="Corbridge, Elizabeth" sort="Corbridge, Elizabeth" uniqKey="Corbridge E" first="Elizabeth" last="Corbridge">Elizabeth Corbridge</name>
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<author><name sortKey="Glassberg, Kathryn" sort="Glassberg, Kathryn" uniqKey="Glassberg K" first="Kathryn" last="Glassberg">Kathryn Glassberg</name>
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<author><name sortKey="Moore, M Milar" sort="Moore, M Milar" uniqKey="Moore M" first="M Milar" last="Moore">M Milar Moore</name>
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<author><name sortKey="Kaye, Jeffrey A" sort="Kaye, Jeffrey A" uniqKey="Kaye J" first="Jeffrey A" last="Kaye">Jeffrey A. Kaye</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Alzheimer Disease (diagnosis)</term>
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<term>Dementia (diagnosis)</term>
<term>Diagnosis, Differential</term>
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<term>Hippocampus (pathology)</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Mathematical Computing</term>
<term>Neurologic Examination</term>
<term>Neuropsychological Tests</term>
<term>Parahippocampal Gyrus (pathology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Red Nucleus (pathology)</term>
<term>Reference Values</term>
<term>Superior Colliculi (pathology)</term>
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<term>Dementia</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Cerebral Cortex</term>
<term>Hippocampus</term>
<term>Parahippocampal Gyrus</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Atrophy</term>
<term>Diagnosis, Differential</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
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<front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) may have hippocampal atrophy compared with controls. We compared hippocampal, and extra-hippocampal volumes between PD, PDD (patients with PD who have mild cognitive impairment or dementia), Alzheimer's disease (AD) and controls using volumetric magnetic resonance imaging (MRI). Participants (10 patients with PD, 10 with PDD, 11 with AD, and 12 control subjects) had an informant interview, neurological examination, and psychometric testing. Established, reliable methods were used to measure the hippocampus, parahippocampal gyrus, temporal, frontal, and parieto-occipital lobes. Correction for intracranial volume was carried out before comparison. There was no age difference between groups (mean age, 74 years). On the Clinical Dementia Rating scale (CDR) cognitive impairment was mild (CDR = 0.5) in the majority of PDD and AD patients. Hippocampal (P < 0.0004) volumes were smaller in the patient groups. Effect sizes compared with the control group were: PD, 0.66; PDD, 1.22; and AD, 1.81. The other volumes did not differ significantly. Among PD and PDD patients, recognition memory (r = 0.54, P = 0.015) and Mini-Mental State Examination scores (r = 0.56, P = 0.01) correlated with left, but not right hippocampal volume. In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early marker for dementia in PD.</div>
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<Abstract><AbstractText>Patients with Parkinson's disease (PD) may have hippocampal atrophy compared with controls. We compared hippocampal, and extra-hippocampal volumes between PD, PDD (patients with PD who have mild cognitive impairment or dementia), Alzheimer's disease (AD) and controls using volumetric magnetic resonance imaging (MRI). Participants (10 patients with PD, 10 with PDD, 11 with AD, and 12 control subjects) had an informant interview, neurological examination, and psychometric testing. Established, reliable methods were used to measure the hippocampus, parahippocampal gyrus, temporal, frontal, and parieto-occipital lobes. Correction for intracranial volume was carried out before comparison. There was no age difference between groups (mean age, 74 years). On the Clinical Dementia Rating scale (CDR) cognitive impairment was mild (CDR = 0.5) in the majority of PDD and AD patients. Hippocampal (P < 0.0004) volumes were smaller in the patient groups. Effect sizes compared with the control group were: PD, 0.66; PDD, 1.22; and AD, 1.81. The other volumes did not differ significantly. Among PD and PDD patients, recognition memory (r = 0.54, P = 0.015) and Mini-Mental State Examination scores (r = 0.56, P = 0.01) correlated with left, but not right hippocampal volume. In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early marker for dementia in PD.</AbstractText>
<CopyrightInformation>Copyright 2003 Movement Disorder Society</CopyrightInformation>
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