Familial influence on parkinsonism in a rural area of Turkey (Kizilcaboluk-Denizli): a community-based case-control study.
Identifieur interne : 003751 ( PubMed/Corpus ); précédent : 003750; suivant : 003752Familial influence on parkinsonism in a rural area of Turkey (Kizilcaboluk-Denizli): a community-based case-control study.
Auteurs : Fusun Duzcan ; Mehmet Zencir ; Fatma Ozdemir ; G Ozan Cetin ; Huseyin Bagci ; Peter Heutink ; Vincenzo Bonifati ; Turker SahinerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Case-Control Studies, Cross-Sectional Studies, Environmental Pollutants (toxicity), Female, Genetic Predisposition to Disease (epidemiology), Genetic Predisposition to Disease (genetics), Genetics, Population (statistics & numerical data), Humans, Incidence, Life Style, Male, Middle Aged, Parkinsonian Disorders (epidemiology), Parkinsonian Disorders (genetics), Pesticides (toxicity), Risk Factors, Rural Population (statistics & numerical data), Social Environment, Social Isolation, Socioeconomic Factors.
- MESH :
- chemical , toxicity : Environmental Pollutants, Pesticides.
- epidemiology : Genetic Predisposition to Disease, Parkinsonian Disorders.
- genetics : Genetic Predisposition to Disease, Parkinsonian Disorders.
- statistics & numerical data : Genetics, Population, Rural Population.
- Aged, Aged, 80 and over, Case-Control Studies, Cross-Sectional Studies, Female, Humans, Incidence, Life Style, Male, Middle Aged, Risk Factors, Social Environment, Social Isolation, Socioeconomic Factors.
Abstract
This population-based study on parkinsonism in a genetically isolated community from a rural area of Turkey aimed to provide a selective evaluation of environmental and heritable risk factors. An increased prevalence of parkinsonism (4.1%) was detected in the village of Kizilcaboluk for people 65 years of age and older. This study included 36 patients with parkinsonism living in Kizilcaboluk and three times that number of age- and sex-matched people serving as controls. A questionnaire including demographic data, family history, education, occupation, data on exposures to pesticides, smoking, alcohol intake, and head trauma was administered. We found a significant association of parkinsonism cases with a positive family history in first-degree relatives (odds ratio [OR], 7.48; 95% confidence interval [CI], 2.52-22.17; P < 0.0001) and with pesticide exposure (OR, 2.96; 95% CI, 1.31-6.69; P = 0.015) compared to the control subjects. The value of genetically isolated populations for the identification of genetic risk factors for common and complex disorders has gained much attention recently because the genetic make-up of these populations is likely to be less complex than that of the general population and our findings should prompt investigations to the nature of a familial aggregation of parkinsonism in this population.
DOI: 10.1002/mds.10440
PubMed: 12815659
Links to Exploration step
pubmed:12815659Le document en format XML
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Bagci</name></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name></author><author><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name></author><author><name sortKey="Sahiner, Turker" sort="Sahiner, Turker" uniqKey="Sahiner T" first="Turker" last="Sahiner">Turker Sahiner</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12815659</idno><idno type="pmid">12815659</idno><idno type="doi">10.1002/mds.10440</idno><idno type="wicri:Area/PubMed/Corpus">003751</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Familial influence on parkinsonism in a rural area of Turkey (Kizilcaboluk-Denizli): a community-based case-control study.</title><author><name sortKey="Duzcan, Fusun" sort="Duzcan, Fusun" uniqKey="Duzcan 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80 and over</term><term>Case-Control Studies</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Life Style</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term><term>Social Environment</term><term>Social Isolation</term><term>Socioeconomic Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This population-based study on parkinsonism in a genetically isolated community from a rural area of Turkey aimed to provide a selective evaluation of environmental and heritable risk factors. An increased prevalence of parkinsonism (4.1%) was detected in the village of Kizilcaboluk for people 65 years of age and older. This study included 36 patients with parkinsonism living in Kizilcaboluk and three times that number of age- and sex-matched people serving as controls. A questionnaire including demographic data, family history, education, occupation, data on exposures to pesticides, smoking, alcohol intake, and head trauma was administered. We found a significant association of parkinsonism cases with a positive family history in first-degree relatives (odds ratio [OR], 7.48; 95% confidence interval [CI], 2.52-22.17; P < 0.0001) and with pesticide exposure (OR, 2.96; 95% CI, 1.31-6.69; P = 0.015) compared to the control subjects. The value of genetically isolated populations for the identification of genetic risk factors for common and complex disorders has gained much attention recently because the genetic make-up of these populations is likely to be less complex than that of the general population and our findings should prompt investigations to the nature of a familial aggregation of parkinsonism in this population.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">12815659</PMID><DateCreated><Year>2003</Year><Month>06</Month><Day>19</Day></DateCreated><DateCompleted><Year>2004</Year><Month>01</Month><Day>28</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>7</Issue><PubDate><Year>2003</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. 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We found a significant association of parkinsonism cases with a positive family history in first-degree relatives (odds ratio [OR], 7.48; 95% confidence interval [CI], 2.52-22.17; P < 0.0001) and with pesticide exposure (OR, 2.96; 95% CI, 1.31-6.69; P = 0.015) compared to the control subjects. 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