Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD.
Identifieur interne : 003544 ( PubMed/Corpus ); précédent : 003543; suivant : 003545Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD.
Auteurs : Jürgen Andrich ; Carsten Saft ; Anneliese Arz ; Birgit Schneider ; Markus W. Agelink ; Peter H. Kraus ; Wilfried Kuhn ; Thomas MüllerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Biological Markers (blood), Central Nervous System Agents (administration & dosage), Central Nervous System Agents (adverse effects), Central Nervous System Agents (pharmacokinetics), Disease Progression, Drug Interactions, Female, Homocysteine (blood), Humans, Huntington Disease (blood), Huntington Disease (diagnosis), Huntington Disease (drug therapy), Hyperhomocysteinemia (blood), Hyperhomocysteinemia (diagnosis), Male, Metabolic Clearance Rate (drug effects), Middle Aged, Mutation (genetics), Nerve Tissue Proteins (genetics), Neurologic Examination, Nuclear Proteins (genetics).
- MESH :
- chemical , administration & dosage : Central Nervous System Agents.
- chemical , adverse effects : Central Nervous System Agents.
- chemical , blood : Biological Markers, Homocysteine.
- chemical , genetics : Nerve Tissue Proteins, Nuclear Proteins.
- chemical , pharmacokinetics : Central Nervous System Agents.
- blood : Huntington Disease, Hyperhomocysteinemia.
- diagnosis : Huntington Disease, Hyperhomocysteinemia.
- drug effects : Metabolic Clearance Rate.
- drug therapy : Huntington Disease.
- genetics : Mutation.
- Adult, Disease Progression, Drug Interactions, Female, Humans, Male, Middle Aged, Neurologic Examination.
Abstract
Significantly increased plasma total homocysteine levels (t-Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD.
DOI: 10.1002/mds.10629
PubMed: 14978683
Links to Exploration step
pubmed:14978683Le document en format XML
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<author><name sortKey="Andrich, Jurgen" sort="Andrich, Jurgen" uniqKey="Andrich J" first="Jürgen" last="Andrich">Jürgen Andrich</name>
<affiliation><nlm:affiliation>Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.</nlm:affiliation>
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<author><name sortKey="Saft, Carsten" sort="Saft, Carsten" uniqKey="Saft C" first="Carsten" last="Saft">Carsten Saft</name>
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<author><name sortKey="Schneider, Birgit" sort="Schneider, Birgit" uniqKey="Schneider B" first="Birgit" last="Schneider">Birgit Schneider</name>
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<term>Disease Progression</term>
<term>Drug Interactions</term>
<term>Female</term>
<term>Homocysteine (blood)</term>
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<front><div type="abstract" xml:lang="en">Significantly increased plasma total homocysteine levels (t-Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD.</div>
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<Abstract><AbstractText>Significantly increased plasma total homocysteine levels (t-Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD.</AbstractText>
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