Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.
Identifieur interne : 003469 ( PubMed/Corpus ); précédent : 003468; suivant : 003470Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.
Auteurs : Meltem Müftüoglu ; Bülent Elibol ; Ozlem Dalmizrak ; Ayse Ercan ; Gülnihal Kulaksiz ; Hamdi Ogüs ; Turgay Dalkara ; Nazmi OzerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Electron Transport Complex I (genetics), Electron Transport Complex I (metabolism), Electron Transport Complex IV (genetics), Electron Transport Complex IV (metabolism), Exons (genetics), Female, Humans, Leukocytes (metabolism), Male, Middle Aged, Parkinson Disease (genetics), Parkinson Disease (metabolism), Point Mutation (genetics), Ubiquitin-Protein Ligases (genetics), Ubiquitin-Protein Ligases (metabolism).
- MESH :
- chemical , genetics : Electron Transport Complex I, Electron Transport Complex IV, Ubiquitin-Protein Ligases.
- chemical , metabolism : Electron Transport Complex I, Electron Transport Complex IV, Ubiquitin-Protein Ligases.
- genetics : Exons, Parkinson Disease, Point Mutation.
- metabolism : Leukocytes, Parkinson Disease.
- Adult, Female, Humans, Male, Middle Aged.
Abstract
The parkin protein functions as a RING-type ubiquitin protein ligase. Considering the possibility that impaired ubiquitin-proteosomal system activity may impair antioxidant defenses and enhance oxidative stress, we have investigated the activity of mitochondrial respiratory enzymes in patients with parkin gene mutations. A significant decrease in the leukocyte complex I activity was found both in patients with parkin mutations (62.5%) and idiopathic PD (64.5%) compared with age-matched controls (P < 0.001). Complex IV activity was also decreased significantly in idiopathic PD patients (60%), but no difference was detected between controls and patients with parkin mutations.
DOI: 10.1002/mds.10695
PubMed: 15133818
Links to Exploration step
pubmed:15133818Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.</title>
<author><name sortKey="Muftuoglu, Meltem" sort="Muftuoglu, Meltem" uniqKey="Muftuoglu M" first="Meltem" last="Müftüoglu">Meltem Müftüoglu</name>
<affiliation><nlm:affiliation>Department of Biochemistry, Hacettepe University, Faculty of Medicine, Ankara, Turkey.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Elibol, Bulent" sort="Elibol, Bulent" uniqKey="Elibol B" first="Bülent" last="Elibol">Bülent Elibol</name>
</author>
<author><name sortKey="Dalmizrak, Ozlem" sort="Dalmizrak, Ozlem" uniqKey="Dalmizrak O" first="Ozlem" last="Dalmizrak">Ozlem Dalmizrak</name>
</author>
<author><name sortKey="Ercan, Ayse" sort="Ercan, Ayse" uniqKey="Ercan A" first="Ayse" last="Ercan">Ayse Ercan</name>
</author>
<author><name sortKey="Kulaksiz, Gulnihal" sort="Kulaksiz, Gulnihal" uniqKey="Kulaksiz G" first="Gülnihal" last="Kulaksiz">Gülnihal Kulaksiz</name>
</author>
<author><name sortKey="Ogus, Hamdi" sort="Ogus, Hamdi" uniqKey="Ogus H" first="Hamdi" last="Ogüs">Hamdi Ogüs</name>
</author>
<author><name sortKey="Dalkara, Turgay" sort="Dalkara, Turgay" uniqKey="Dalkara T" first="Turgay" last="Dalkara">Turgay Dalkara</name>
</author>
<author><name sortKey="Ozer, Nazmi" sort="Ozer, Nazmi" uniqKey="Ozer N" first="Nazmi" last="Ozer">Nazmi Ozer</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.</title>
<author><name sortKey="Muftuoglu, Meltem" sort="Muftuoglu, Meltem" uniqKey="Muftuoglu M" first="Meltem" last="Müftüoglu">Meltem Müftüoglu</name>
<affiliation><nlm:affiliation>Department of Biochemistry, Hacettepe University, Faculty of Medicine, Ankara, Turkey.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Elibol, Bulent" sort="Elibol, Bulent" uniqKey="Elibol B" first="Bülent" last="Elibol">Bülent Elibol</name>
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<author><name sortKey="Dalmizrak, Ozlem" sort="Dalmizrak, Ozlem" uniqKey="Dalmizrak O" first="Ozlem" last="Dalmizrak">Ozlem Dalmizrak</name>
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<author><name sortKey="Ercan, Ayse" sort="Ercan, Ayse" uniqKey="Ercan A" first="Ayse" last="Ercan">Ayse Ercan</name>
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<author><name sortKey="Kulaksiz, Gulnihal" sort="Kulaksiz, Gulnihal" uniqKey="Kulaksiz G" first="Gülnihal" last="Kulaksiz">Gülnihal Kulaksiz</name>
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<author><name sortKey="Ogus, Hamdi" sort="Ogus, Hamdi" uniqKey="Ogus H" first="Hamdi" last="Ogüs">Hamdi Ogüs</name>
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<author><name sortKey="Dalkara, Turgay" sort="Dalkara, Turgay" uniqKey="Dalkara T" first="Turgay" last="Dalkara">Turgay Dalkara</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2004" type="published">2004</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Electron Transport Complex I (genetics)</term>
<term>Electron Transport Complex I (metabolism)</term>
<term>Electron Transport Complex IV (genetics)</term>
<term>Electron Transport Complex IV (metabolism)</term>
<term>Exons (genetics)</term>
<term>Female</term>
<term>Humans</term>
<term>Leukocytes (metabolism)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Point Mutation (genetics)</term>
<term>Ubiquitin-Protein Ligases (genetics)</term>
<term>Ubiquitin-Protein Ligases (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Electron Transport Complex I</term>
<term>Electron Transport Complex IV</term>
<term>Ubiquitin-Protein Ligases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Electron Transport Complex I</term>
<term>Electron Transport Complex IV</term>
<term>Ubiquitin-Protein Ligases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Exons</term>
<term>Parkinson Disease</term>
<term>Point Mutation</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">The parkin protein functions as a RING-type ubiquitin protein ligase. Considering the possibility that impaired ubiquitin-proteosomal system activity may impair antioxidant defenses and enhance oxidative stress, we have investigated the activity of mitochondrial respiratory enzymes in patients with parkin gene mutations. A significant decrease in the leukocyte complex I activity was found both in patients with parkin mutations (62.5%) and idiopathic PD (64.5%) compared with age-matched controls (P < 0.001). Complex IV activity was also decreased significantly in idiopathic PD patients (60%), but no difference was detected between controls and patients with parkin mutations.</div>
</front>
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<DateCreated><Year>2004</Year>
<Month>05</Month>
<Day>10</Day>
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<DateCompleted><Year>2004</Year>
<Month>09</Month>
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<Day>15</Day>
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<JournalIssue CitedMedium="Print"><Volume>19</Volume>
<Issue>5</Issue>
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<Month>May</Month>
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</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.</ArticleTitle>
<Pagination><MedlinePgn>544-8</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The parkin protein functions as a RING-type ubiquitin protein ligase. Considering the possibility that impaired ubiquitin-proteosomal system activity may impair antioxidant defenses and enhance oxidative stress, we have investigated the activity of mitochondrial respiratory enzymes in patients with parkin gene mutations. A significant decrease in the leukocyte complex I activity was found both in patients with parkin mutations (62.5%) and idiopathic PD (64.5%) compared with age-matched controls (P < 0.001). Complex IV activity was also decreased significantly in idiopathic PD patients (60%), but no difference was detected between controls and patients with parkin mutations.</AbstractText>
<CopyrightInformation>Copyright 2003 Movement Disorder Society</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Müftüoglu</LastName>
<ForeName>Meltem</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Hacettepe University, Faculty of Medicine, Ankara, Turkey.</Affiliation>
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<Author ValidYN="Y"><LastName>Elibol</LastName>
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<Author ValidYN="Y"><LastName>Dalmizrak</LastName>
<ForeName>Ozlem</ForeName>
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<ChemicalList><Chemical><RegistryNumber>EC 1.6.5.3</RegistryNumber>
<NameOfSubstance UI="D042967">Electron Transport Complex I</NameOfSubstance>
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<Chemical><RegistryNumber>EC 1.9.3.1</RegistryNumber>
<NameOfSubstance UI="D003576">Electron Transport Complex IV</NameOfSubstance>
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<Chemical><RegistryNumber>EC 6.3.2.19</RegistryNumber>
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<Chemical><RegistryNumber>EC 6.3.2.19</RegistryNumber>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D003576">Electron Transport Complex IV</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
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<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
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</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D044767">Ubiquitin-Protein Ligases</DescriptorName>
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