MovDisordV3, PubMed, Corpus, bibRecord, 003469

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

Identifieur interne : 003469 ( PubMed/Corpus ); précédent : 003468; suivant : 003470

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

Auteurs : Meltem Müftüoglu ; Bülent Elibol ; Ozlem Dalmizrak ; Ayse Ercan ; Gülnihal Kulaksiz ; Hamdi Ogüs ; Turgay Dalkara ; Nazmi Ozer

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2004.

RBID : pubmed:15133818

English descriptors

KwdEn :
- Adult, Electron Transport Complex I (genetics), Electron Transport Complex I (metabolism), Electron Transport Complex IV (genetics), Electron Transport Complex IV (metabolism), Exons (genetics), Female, Humans, Leukocytes (metabolism), Male, Middle Aged, Parkinson Disease (genetics), Parkinson Disease (metabolism), Point Mutation (genetics), Ubiquitin-Protein Ligases (genetics), Ubiquitin-Protein Ligases (metabolism).
MESH :
- chemical , genetics : Electron Transport Complex I, Electron Transport Complex IV, Ubiquitin-Protein Ligases.
- chemical , metabolism : Electron Transport Complex I, Electron Transport Complex IV, Ubiquitin-Protein Ligases.
- genetics : Exons, Parkinson Disease, Point Mutation.
- metabolism : Leukocytes, Parkinson Disease.
- Adult, Female, Humans, Male, Middle Aged.

Abstract

The parkin protein functions as a RING-type ubiquitin protein ligase. Considering the possibility that impaired ubiquitin-proteosomal system activity may impair antioxidant defenses and enhance oxidative stress, we have investigated the activity of mitochondrial respiratory enzymes in patients with parkin gene mutations. A significant decrease in the leukocyte complex I activity was found both in patients with parkin mutations (62.5%) and idiopathic PD (64.5%) compared with age-matched controls (P < 0.001). Complex IV activity was also decreased significantly in idiopathic PD patients (60%), but no difference was detected between controls and patients with parkin mutations.

DOI: 10.1002/mds.10695
PubMed: 15133818

Links to Exploration step

pubmed:15133818

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.</title>
<author><name sortKey="Muftuoglu, Meltem" sort="Muftuoglu, Meltem" uniqKey="Muftuoglu M" first="Meltem" last="Müftüoglu">Meltem Müftüoglu</name>
<affiliation><nlm:affiliation>Department of Biochemistry, Hacettepe University, Faculty of Medicine, Ankara, Turkey.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Elibol, Bulent" sort="Elibol, Bulent" uniqKey="Elibol B" first="Bülent" last="Elibol">Bülent Elibol</name>
</author>
<author><name sortKey="Dalmizrak, Ozlem" sort="Dalmizrak, Ozlem" uniqKey="Dalmizrak O" first="Ozlem" last="Dalmizrak">Ozlem Dalmizrak</name>
</author>
<author><name sortKey="Ercan, Ayse" sort="Ercan, Ayse" uniqKey="Ercan A" first="Ayse" last="Ercan">Ayse Ercan</name>
</author>
<author><name sortKey="Kulaksiz, Gulnihal" sort="Kulaksiz, Gulnihal" uniqKey="Kulaksiz G" first="Gülnihal" last="Kulaksiz">Gülnihal Kulaksiz</name>
</author>
<author><name sortKey="Ogus, Hamdi" sort="Ogus, Hamdi" uniqKey="Ogus H" first="Hamdi" last="Ogüs">Hamdi Ogüs</name>
</author>
<author><name sortKey="Dalkara, Turgay" sort="Dalkara, Turgay" uniqKey="Dalkara T" first="Turgay" last="Dalkara">Turgay Dalkara</name>
</author>
<author><name sortKey="Ozer, Nazmi" sort="Ozer, Nazmi" uniqKey="Ozer N" first="Nazmi" last="Ozer">Nazmi Ozer</name>
</author>
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<idno type="doi">10.1002/mds.10695</idno>
<idno type="wicri:Area/PubMed/Corpus">003469</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.</title>
<author><name sortKey="Muftuoglu, Meltem" sort="Muftuoglu, Meltem" uniqKey="Muftuoglu M" first="Meltem" last="Müftüoglu">Meltem Müftüoglu</name>
<affiliation><nlm:affiliation>Department of Biochemistry, Hacettepe University, Faculty of Medicine, Ankara, Turkey.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Elibol, Bulent" sort="Elibol, Bulent" uniqKey="Elibol B" first="Bülent" last="Elibol">Bülent Elibol</name>
</author>
<author><name sortKey="Dalmizrak, Ozlem" sort="Dalmizrak, Ozlem" uniqKey="Dalmizrak O" first="Ozlem" last="Dalmizrak">Ozlem Dalmizrak</name>
</author>
<author><name sortKey="Ercan, Ayse" sort="Ercan, Ayse" uniqKey="Ercan A" first="Ayse" last="Ercan">Ayse Ercan</name>
</author>
<author><name sortKey="Kulaksiz, Gulnihal" sort="Kulaksiz, Gulnihal" uniqKey="Kulaksiz G" first="Gülnihal" last="Kulaksiz">Gülnihal Kulaksiz</name>
</author>
<author><name sortKey="Ogus, Hamdi" sort="Ogus, Hamdi" uniqKey="Ogus H" first="Hamdi" last="Ogüs">Hamdi Ogüs</name>
</author>
<author><name sortKey="Dalkara, Turgay" sort="Dalkara, Turgay" uniqKey="Dalkara T" first="Turgay" last="Dalkara">Turgay Dalkara</name>
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<author><name sortKey="Ozer, Nazmi" sort="Ozer, Nazmi" uniqKey="Ozer N" first="Nazmi" last="Ozer">Nazmi Ozer</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2004" type="published">2004</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Electron Transport Complex I (genetics)</term>
<term>Electron Transport Complex I (metabolism)</term>
<term>Electron Transport Complex IV (genetics)</term>
<term>Electron Transport Complex IV (metabolism)</term>
<term>Exons (genetics)</term>
<term>Female</term>
<term>Humans</term>
<term>Leukocytes (metabolism)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Point Mutation (genetics)</term>
<term>Ubiquitin-Protein Ligases (genetics)</term>
<term>Ubiquitin-Protein Ligases (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Electron Transport Complex I</term>
<term>Electron Transport Complex IV</term>
<term>Ubiquitin-Protein Ligases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Electron Transport Complex I</term>
<term>Electron Transport Complex IV</term>
<term>Ubiquitin-Protein Ligases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Exons</term>
<term>Parkinson Disease</term>
<term>Point Mutation</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The parkin protein functions as a RING-type ubiquitin protein ligase. Considering the possibility that impaired ubiquitin-proteosomal system activity may impair antioxidant defenses and enhance oxidative stress, we have investigated the activity of mitochondrial respiratory enzymes in patients with parkin gene mutations. A significant decrease in the leukocyte complex I activity was found both in patients with parkin mutations (62.5%) and idiopathic PD (64.5%) compared with age-matched controls (P < 0.001). Complex IV activity was also decreased significantly in idiopathic PD patients (60%), but no difference was detected between controls and patients with parkin mutations.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">15133818</PMID>
<DateCreated><Year>2004</Year>
<Month>05</Month>
<Day>10</Day>
</DateCreated>
<DateCompleted><Year>2004</Year>
<Month>09</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN>
<JournalIssue CitedMedium="Print"><Volume>19</Volume>
<Issue>5</Issue>
<PubDate><Year>2004</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.</ArticleTitle>
<Pagination><MedlinePgn>544-8</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The parkin protein functions as a RING-type ubiquitin protein ligase. Considering the possibility that impaired ubiquitin-proteosomal system activity may impair antioxidant defenses and enhance oxidative stress, we have investigated the activity of mitochondrial respiratory enzymes in patients with parkin gene mutations. A significant decrease in the leukocyte complex I activity was found both in patients with parkin mutations (62.5%) and idiopathic PD (64.5%) compared with age-matched controls (P < 0.001). Complex IV activity was also decreased significantly in idiopathic PD patients (60%), but no difference was detected between controls and patients with parkin mutations.</AbstractText>
<CopyrightInformation>Copyright 2003 Movement Disorder Society</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Müftüoglu</LastName>
<ForeName>Meltem</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Hacettepe University, Faculty of Medicine, Ankara, Turkey.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Elibol</LastName>
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<Author ValidYN="Y"><LastName>Dalmizrak</LastName>
<ForeName>Ozlem</ForeName>
<Initials>O</Initials>
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<Author ValidYN="Y"><LastName>Ercan</LastName>
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<Author ValidYN="Y"><LastName>Kulaksiz</LastName>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>EC 1.6.5.3</RegistryNumber>
<NameOfSubstance UI="D042967">Electron Transport Complex I</NameOfSubstance>
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<Chemical><RegistryNumber>EC 1.9.3.1</RegistryNumber>
<NameOfSubstance UI="D003576">Electron Transport Complex IV</NameOfSubstance>
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<Chemical><RegistryNumber>EC 6.3.2.19</RegistryNumber>
<NameOfSubstance UI="D044767">Ubiquitin-Protein Ligases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 6.3.2.19</RegistryNumber>
<NameOfSubstance UI="C111567">parkin protein</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName>
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<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D003576">Electron Transport Complex IV</DescriptorName>
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<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
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</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D017354">Point Mutation</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D044767">Ubiquitin-Protein Ligases</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki