MovDisordV3, PubMed, Corpus, bibRecord, 003233

Evidence for a disorder of locomotor timing in Huntington's disease.

Identifieur interne : 003233 ( PubMed/Corpus ); précédent : 003232; suivant : 003234

Evidence for a disorder of locomotor timing in Huntington's disease.

Auteurs : Belinda Bilney ; Meg E. Morris ; Andrew Churchyard ; Edmond Chiu ; Nellie Georgiou-Karistianis

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.

RBID : pubmed:15390128

English descriptors

KwdEn :
- Acoustic Stimulation, Adult, Analysis of Variance, Case-Control Studies, Cues, Female, Gait (physiology), Gait Disorders, Neurologic (etiology), Humans, Huntington Disease (physiopathology), Male, Mental Status Schedule, Middle Aged, Neurologic Examination (methods), Postural Balance (physiology), Time Factors, Walking (physiology).
MESH :
- etiology : Gait Disorders, Neurologic.
- methods : Neurologic Examination.
- physiology : Gait, Postural Balance, Walking.
- physiopathology : Huntington Disease.
- Acoustic Stimulation, Adult, Analysis of Variance, Case-Control Studies, Cues, Female, Humans, Male, Mental Status Schedule, Middle Aged, Time Factors.

Abstract

Disturbances of walking have been described in people with Huntington's disease (HD), although the nature of the deficits have not yet been well defined. The purpose of this investigation was to determine whether people with HD have a deficit in the regulation of footstep timing during walking. The footstep patterns of 30 people with HD and 30 matched comparisons were measured at self-selected slow, preferred, and fast speeds. Subjects were also instructed to match their footsteps to auditory metronome cues set at 80 and 120 beats per minute. Gait speed, cadence, stride length, and double limb support as a percentage of the gait cycle were measured using a computerized foot-switch system. People with HD demonstrated a disorder in their ability to regulate cadence, manifest as a reduced step frequency when walking at preferred speed and when required to increase their speed. For all walking conditions, people with HD had increased variability of footstep cadence. They also had difficulty synchronizing their footstep timing to an auditory cue. For all walking conditions, people with HD had reduced stride length. Thus, in HD, there is a disorder in the regulation of footstep timing, with increased variability, a restricted cadence range, difficulty synchronizing footsteps to an auditory cue and reduced stride length. The exact neural correlates of this timing disorder are yet to be determined.

DOI: 10.1002/mds.20294
PubMed: 15390128

Links to Exploration step

pubmed:15390128

Le document en format XML

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<author><name sortKey="Bilney, Belinda" sort="Bilney, Belinda" uniqKey="Bilney B" first="Belinda" last="Bilney">Belinda Bilney</name>
<affiliation><nlm:affiliation>School of Physiotherapy, La Trobe University, Victoria, Australia. b.bilney@latrobe.edu.au</nlm:affiliation>
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<author><name sortKey="Morris, Meg E" sort="Morris, Meg E" uniqKey="Morris M" first="Meg E" last="Morris">Meg E. Morris</name>
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<author><name sortKey="Churchyard, Andrew" sort="Churchyard, Andrew" uniqKey="Churchyard A" first="Andrew" last="Churchyard">Andrew Churchyard</name>
</author>
<author><name sortKey="Chiu, Edmond" sort="Chiu, Edmond" uniqKey="Chiu E" first="Edmond" last="Chiu">Edmond Chiu</name>
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<author><name sortKey="Georgiou Karistianis, Nellie" sort="Georgiou Karistianis, Nellie" uniqKey="Georgiou Karistianis N" first="Nellie" last="Georgiou-Karistianis">Nellie Georgiou-Karistianis</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Evidence for a disorder of locomotor timing in Huntington's disease.</title>
<author><name sortKey="Bilney, Belinda" sort="Bilney, Belinda" uniqKey="Bilney B" first="Belinda" last="Bilney">Belinda Bilney</name>
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<author><name sortKey="Morris, Meg E" sort="Morris, Meg E" uniqKey="Morris M" first="Meg E" last="Morris">Meg E. Morris</name>
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<author><name sortKey="Chiu, Edmond" sort="Chiu, Edmond" uniqKey="Chiu E" first="Edmond" last="Chiu">Edmond Chiu</name>
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<term>Gait (physiology)</term>
<term>Gait Disorders, Neurologic (etiology)</term>
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<term>Analysis of Variance</term>
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<term>Cues</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Disturbances of walking have been described in people with Huntington's disease (HD), although the nature of the deficits have not yet been well defined. The purpose of this investigation was to determine whether people with HD have a deficit in the regulation of footstep timing during walking. The footstep patterns of 30 people with HD and 30 matched comparisons were measured at self-selected slow, preferred, and fast speeds. Subjects were also instructed to match their footsteps to auditory metronome cues set at 80 and 120 beats per minute. Gait speed, cadence, stride length, and double limb support as a percentage of the gait cycle were measured using a computerized foot-switch system. People with HD demonstrated a disorder in their ability to regulate cadence, manifest as a reduced step frequency when walking at preferred speed and when required to increase their speed. For all walking conditions, people with HD had increased variability of footstep cadence. They also had difficulty synchronizing their footstep timing to an auditory cue. For all walking conditions, people with HD had reduced stride length. Thus, in HD, there is a disorder in the regulation of footstep timing, with increased variability, a restricted cadence range, difficulty synchronizing footsteps to an auditory cue and reduced stride length. The exact neural correlates of this timing disorder are yet to be determined.</div>
</front>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Evidence for a disorder of locomotor timing in Huntington's disease.</ArticleTitle>
<Pagination><MedlinePgn>51-7</MedlinePgn>
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<Abstract><AbstractText>Disturbances of walking have been described in people with Huntington's disease (HD), although the nature of the deficits have not yet been well defined. The purpose of this investigation was to determine whether people with HD have a deficit in the regulation of footstep timing during walking. The footstep patterns of 30 people with HD and 30 matched comparisons were measured at self-selected slow, preferred, and fast speeds. Subjects were also instructed to match their footsteps to auditory metronome cues set at 80 and 120 beats per minute. Gait speed, cadence, stride length, and double limb support as a percentage of the gait cycle were measured using a computerized foot-switch system. People with HD demonstrated a disorder in their ability to regulate cadence, manifest as a reduced step frequency when walking at preferred speed and when required to increase their speed. For all walking conditions, people with HD had increased variability of footstep cadence. They also had difficulty synchronizing their footstep timing to an auditory cue. For all walking conditions, people with HD had reduced stride length. Thus, in HD, there is a disorder in the regulation of footstep timing, with increased variability, a restricted cadence range, difficulty synchronizing footsteps to an auditory cue and reduced stride length. The exact neural correlates of this timing disorder are yet to be determined.</AbstractText>
<CopyrightInformation>(c) 2004 Movement Disorder Society.</CopyrightInformation>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Evidence for a disorder of locomotor timing in Huntington's disease.

Evidence for a disorder of locomotor timing in Huntington's disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki