Pallidotomy effect on the cortical excitability in patients with severe Parkinson's disease.
Identifieur interne : 003185 ( PubMed/Corpus ); précédent : 003184; suivant : 003186Pallidotomy effect on the cortical excitability in patients with severe Parkinson's disease.
Auteurs : Chon-Haw Tsai ; Fang-Chia Chang ; Chin-Song Lu ; Shih-Tseng Lee ; Yu-Ting Huang ; Ming-Kuei Lu ; Rou-Shayn Chen ; Tony Wu ; Jiann-Der Lee ; Yi-Hsin Weng ; Hsiu-Chen ChangSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Adult, Aged, Electromyography (instrumentation), Female, Globus Pallidus (physiopathology), Globus Pallidus (surgery), Humans, Male, Middle Aged, Motor Cortex (physiopathology), Nerve Net (physiopathology), Neural Inhibition (physiology), Neurosurgical Procedures (methods), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Preoperative Care, Thalamus (physiopathology).
- MESH :
- instrumentation : Electromyography.
- methods : Neurosurgical Procedures.
- physiology : Neural Inhibition.
- physiopathology : Globus Pallidus, Motor Cortex, Nerve Net, Parkinson Disease, Thalamus.
- surgery : Globus Pallidus, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Preoperative Care.
Abstract
Surgical lesions in the medial pallidum have been shown to ameliorate motor deficits in patients with Parkinson's disease (PD). It is believed that interruption of the pallidothalamocortical projections to the motor cortex is required for the satisfactory results. In this report, we adopt cortico-cortical inhibition as the tool to assess the pallidotomy effect on cortical excitability in PD. Interstimulus interval between 1 and 15 msec were investigated. The average peak-to-peak amplitude was measured and calculated at each delay. A total of 8 patients (M:F = 4:4) 54.9 years of age (SD = 9.6) and 10 controls were recruited for the study. In the controls, the inhibitory phenomenon was observed from the 1-msec to the 4-msec delay points and the maximal inhibition was at the 3-msec delay point (33.69% +/- 6.50% of the control response). Mild facilitation was noticed since the 5-msec delay point and thereafter. In patients before operation, a similar trend of inhibition was also observed in the initial 4 msec with the maximal inhibition also at the 3-msec delay point (64.66 +/- 6.77% of the control response). In the postoperative group, the short interstimulus interval inhibition can no longer be observed and the conditioned response was 95.06 +/- 23.68% of the control at the 3-msec delay point. The suppression was gone at and after the 7-msec delay point. Results of repeated-measures analysis of variance show a significant difference among the controls and PD patients before and 3 months after pallidotomy (F = 3.40, P = 0.05). Post hoc examination revealed a significant difference between the controls and PD patients 3 months after pallidotomy at the 3-msec delay point (P = 0.004). However, no correlation was observed between the 3-msec inhibition and the Unified Parkinson's Disease Rating Scale Motor score or the dyskinesia score. The results suggest that pallidotomy can modulate the cortical inhibitory circuitry in patients with PD.
DOI: 10.1002/mds.20344
PubMed: 15593137
Links to Exploration step
pubmed:15593137Le document en format XML
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first="Yu-Ting" last="Huang">Yu-Ting Huang</name></author><author><name sortKey="Lu, Ming Kuei" sort="Lu, Ming Kuei" uniqKey="Lu M" first="Ming-Kuei" last="Lu">Ming-Kuei Lu</name></author><author><name sortKey="Chen, Rou Shayn" sort="Chen, Rou Shayn" uniqKey="Chen R" first="Rou-Shayn" last="Chen">Rou-Shayn Chen</name></author><author><name sortKey="Wu, Tony" sort="Wu, Tony" uniqKey="Wu T" first="Tony" last="Wu">Tony Wu</name></author><author><name sortKey="Lee, Jiann Der" sort="Lee, Jiann Der" uniqKey="Lee J" first="Jiann-Der" last="Lee">Jiann-Der Lee</name></author><author><name sortKey="Weng, Yi Hsin" sort="Weng, Yi Hsin" uniqKey="Weng Y" first="Yi-Hsin" last="Weng">Yi-Hsin Weng</name></author><author><name sortKey="Chang, Hsiu Chen" sort="Chang, Hsiu Chen" uniqKey="Chang H" first="Hsiu-Chen" last="Chang">Hsiu-Chen Chang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20344</idno><idno type="RBID">pubmed:15593137</idno><idno type="pmid">15593137</idno><idno type="wicri:Area/PubMed/Corpus">003185</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pallidotomy effect on the cortical excitability in patients with severe Parkinson's disease.</title><author><name sortKey="Tsai, Chon Haw" sort="Tsai, Chon Haw" uniqKey="Tsai C" first="Chon-Haw" last="Tsai">Chon-Haw Tsai</name><affiliation><nlm:affiliation>Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan, Republic of China. d8079@www.cmuh.org.tw</nlm:affiliation></affiliation></author><author><name sortKey="Chang, Fang Chia" sort="Chang, Fang Chia" uniqKey="Chang F" first="Fang-Chia" last="Chang">Fang-Chia Chang</name></author><author><name sortKey="Lu, Chin Song" sort="Lu, Chin Song" uniqKey="Lu C" first="Chin-Song" last="Lu">Chin-Song Lu</name></author><author><name sortKey="Lee, Shih Tseng" sort="Lee, Shih Tseng" uniqKey="Lee S" first="Shih-Tseng" last="Lee">Shih-Tseng Lee</name></author><author><name sortKey="Huang, Yu Ting" sort="Huang, Yu Ting" uniqKey="Huang Y" first="Yu-Ting" last="Huang">Yu-Ting Huang</name></author><author><name sortKey="Lu, Ming Kuei" sort="Lu, Ming Kuei" uniqKey="Lu M" first="Ming-Kuei" last="Lu">Ming-Kuei Lu</name></author><author><name sortKey="Chen, Rou Shayn" sort="Chen, Rou Shayn" uniqKey="Chen R" first="Rou-Shayn" last="Chen">Rou-Shayn Chen</name></author><author><name sortKey="Wu, Tony" sort="Wu, Tony" uniqKey="Wu T" first="Tony" last="Wu">Tony Wu</name></author><author><name sortKey="Lee, Jiann Der" sort="Lee, Jiann Der" uniqKey="Lee J" first="Jiann-Der" last="Lee">Jiann-Der Lee</name></author><author><name sortKey="Weng, Yi Hsin" sort="Weng, Yi Hsin" uniqKey="Weng Y" first="Yi-Hsin" last="Weng">Yi-Hsin Weng</name></author><author><name sortKey="Chang, Hsiu Chen" sort="Chang, Hsiu Chen" uniqKey="Chang H" first="Hsiu-Chen" last="Chang">Hsiu-Chen Chang</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Electromyography (instrumentation)</term><term>Female</term><term>Globus Pallidus (physiopathology)</term><term>Globus Pallidus (surgery)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Nerve Net (physiopathology)</term><term>Neural Inhibition (physiology)</term><term>Neurosurgical Procedures (methods)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Preoperative Care</term><term>Thalamus (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neurosurgical Procedures</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Globus Pallidus</term><term>Motor Cortex</term><term>Nerve Net</term><term>Parkinson Disease</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Preoperative Care</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Surgical lesions in the medial pallidum have been shown to ameliorate motor deficits in patients with Parkinson's disease (PD). It is believed that interruption of the pallidothalamocortical projections to the motor cortex is required for the satisfactory results. In this report, we adopt cortico-cortical inhibition as the tool to assess the pallidotomy effect on cortical excitability in PD. Interstimulus interval between 1 and 15 msec were investigated. The average peak-to-peak amplitude was measured and calculated at each delay. A total of 8 patients (M:F = 4:4) 54.9 years of age (SD = 9.6) and 10 controls were recruited for the study. In the controls, the inhibitory phenomenon was observed from the 1-msec to the 4-msec delay points and the maximal inhibition was at the 3-msec delay point (33.69% +/- 6.50% of the control response). Mild facilitation was noticed since the 5-msec delay point and thereafter. In patients before operation, a similar trend of inhibition was also observed in the initial 4 msec with the maximal inhibition also at the 3-msec delay point (64.66 +/- 6.77% of the control response). In the postoperative group, the short interstimulus interval inhibition can no longer be observed and the conditioned response was 95.06 +/- 23.68% of the control at the 3-msec delay point. The suppression was gone at and after the 7-msec delay point. Results of repeated-measures analysis of variance show a significant difference among the controls and PD patients before and 3 months after pallidotomy (F = 3.40, P = 0.05). Post hoc examination revealed a significant difference between the controls and PD patients 3 months after pallidotomy at the 3-msec delay point (P = 0.004). However, no correlation was observed between the 3-msec inhibition and the Unified Parkinson's Disease Rating Scale Motor score or the dyskinesia score. The results suggest that pallidotomy can modulate the cortical inhibitory circuitry in patients with PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">15593137</PMID><DateCreated><Year>2005</Year><Month>04</Month><Day>13</Day></DateCreated><DateCompleted><Year>2005</Year><Month>08</Month><Day>25</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>4</Issue><PubDate><Year>2005</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Pallidotomy effect on the cortical excitability in patients with severe Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>463-70</MedlinePgn></Pagination><Abstract><AbstractText>Surgical lesions in the medial pallidum have been shown to ameliorate motor deficits in patients with Parkinson's disease (PD). It is believed that interruption of the pallidothalamocortical projections to the motor cortex is required for the satisfactory results. In this report, we adopt cortico-cortical inhibition as the tool to assess the pallidotomy effect on cortical excitability in PD. Interstimulus interval between 1 and 15 msec were investigated. The average peak-to-peak amplitude was measured and calculated at each delay. A total of 8 patients (M:F = 4:4) 54.9 years of age (SD = 9.6) and 10 controls were recruited for the study. In the controls, the inhibitory phenomenon was observed from the 1-msec to the 4-msec delay points and the maximal inhibition was at the 3-msec delay point (33.69% +/- 6.50% of the control response). Mild facilitation was noticed since the 5-msec delay point and thereafter. In patients before operation, a similar trend of inhibition was also observed in the initial 4 msec with the maximal inhibition also at the 3-msec delay point (64.66 +/- 6.77% of the control response). In the postoperative group, the short interstimulus interval inhibition can no longer be observed and the conditioned response was 95.06 +/- 23.68% of the control at the 3-msec delay point. The suppression was gone at and after the 7-msec delay point. Results of repeated-measures analysis of variance show a significant difference among the controls and PD patients before and 3 months after pallidotomy (F = 3.40, P = 0.05). Post hoc examination revealed a significant difference between the controls and PD patients 3 months after pallidotomy at the 3-msec delay point (P = 0.004). However, no correlation was observed between the 3-msec inhibition and the Unified Parkinson's Disease Rating Scale Motor score or the dyskinesia score. The results suggest that pallidotomy can modulate the cortical inhibitory circuitry in patients with PD.</AbstractText><CopyrightInformation>Copyright 2004 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tsai</LastName><ForeName>Chon-Haw</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan, Republic of China. d8079@www.cmuh.org.tw</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Fang-Chia</ForeName><Initials>FC</Initials></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Chin-Song</ForeName><Initials>CS</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Shih-Tseng</ForeName><Initials>ST</Initials></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Yu-Ting</ForeName><Initials>YT</Initials></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Ming-Kuei</ForeName><Initials>MK</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Rou-Shayn</ForeName><Initials>RS</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Tony</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jiann-Der</ForeName><Initials>JD</Initials></Author><Author ValidYN="Y"><LastName>Weng</LastName><ForeName>Yi-Hsin</ForeName><Initials>YH</Initials></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Hsiu-Chen</ForeName><Initials>HC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000295">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005917">Globus Pallidus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009044">Motor Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009415">Nerve Net</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009433">Neural Inhibition</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019635">Neurosurgical Procedures</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011300">Preoperative Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013788">Thalamus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>12</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>8</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>12</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.20344</ArticleId><ArticleId IdType="pubmed">15593137</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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