Quantitative measurements of alternating finger tapping in Parkinson's disease correlate with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation.
Identifieur interne : 003010 ( PubMed/Corpus ); précédent : 003009; suivant : 003011Quantitative measurements of alternating finger tapping in Parkinson's disease correlate with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation.
Auteurs : Ana Lisa Taylor Tavares ; Gregory S X E. Jefferis ; Mandy Koop ; Bruce C. Hill ; Trevor Hastie ; Gary Heit ; Helen M. Bronte-StewartSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Biomechanical Phenomena, Brain (physiopathology), Brain (surgery), Deep Brain Stimulation (methods), Disability Evaluation, Dopamine Agonists (therapeutic use), Electrodes, Implanted, Electromyography (instrumentation), Fingers (physiopathology), Humans, Levodopa (therapeutic use), Middle Aged, Movement Disorders (diagnosis), Movement Disorders (physiopathology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Periodicity, Postoperative Care, Preoperative Care, Questionnaires, Severity of Illness Index, User-Computer Interface.
- MESH :
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- diagnosis : Movement Disorders, Parkinson Disease.
- instrumentation : Electromyography.
- methods : Deep Brain Stimulation.
- physiopathology : Brain, Fingers, Movement Disorders, Parkinson Disease.
- surgery : Brain.
- therapy : Parkinson Disease.
- Biomechanical Phenomena, Disability Evaluation, Electrodes, Implanted, Humans, Middle Aged, Periodicity, Postoperative Care, Preoperative Care, Questionnaires, Severity of Illness Index, User-Computer Interface.
Abstract
The Unified Parkinson's Disease Rating Scale (UPDRS) is the primary outcome measure in most clinical trials of Parkinson's disease (PD) therapeutics. Each subscore of the motor section (UPDRS III) compresses a wide range of motor performance into a coarse-grained scale from 0 to 4; the assessment of performance can also be subjective. Quantitative digitography (QDG) is an objective, quantitative assessment of digital motor control using a computer-interfaced musical keyboard. In this study, we show that the kinematics of a repetitive alternating finger-tapping (RAFT) task using QDG correlate with the UPDRS motor score, particularly with the bradykinesia subscore, in 33 patients with PD. We show that dopaminergic medication and an average of 9.5 months of bilateral subthalamic nucleus deep brain stimulation (B-STN DBS) significantly improve UPDRS and QDG scores but may have different effects on certain kinematic parameters. This study substantiates the use of QDG to measure motor outcome in trials of PD therapeutics and shows that medication and B-STN DBS both improve fine motor control.
DOI: 10.1002/mds.20556
PubMed: 16001401
Links to Exploration step
pubmed:16001401Le document en format XML
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Jefferis</name></author><author><name sortKey="Koop, Mandy" sort="Koop, Mandy" uniqKey="Koop M" first="Mandy" last="Koop">Mandy Koop</name></author><author><name sortKey="Hill, Bruce C" sort="Hill, Bruce C" uniqKey="Hill B" first="Bruce C" last="Hill">Bruce C. Hill</name></author><author><name sortKey="Hastie, Trevor" sort="Hastie, Trevor" uniqKey="Hastie T" first="Trevor" last="Hastie">Trevor Hastie</name></author><author><name sortKey="Heit, Gary" sort="Heit, Gary" uniqKey="Heit G" first="Gary" last="Heit">Gary Heit</name></author><author><name sortKey="Bronte Stewart, Helen M" sort="Bronte Stewart, Helen M" uniqKey="Bronte Stewart H" first="Helen M" last="Bronte-Stewart">Helen M. Bronte-Stewart</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20556</idno><idno type="RBID">pubmed:16001401</idno><idno type="pmid">16001401</idno><idno type="wicri:Area/PubMed/Corpus">003010</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Quantitative measurements of alternating finger tapping in Parkinson's disease correlate with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation.</title><author><name sortKey="Taylor Tavares, Ana Lisa" sort="Taylor Tavares, Ana Lisa" uniqKey="Taylor Tavares A" first="Ana Lisa" last="Taylor Tavares">Ana Lisa Taylor Tavares</name><affiliation><nlm:affiliation>Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305-5327, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jefferis, Gregory S X E" sort="Jefferis, Gregory S X E" uniqKey="Jefferis G" first="Gregory S X E" last="Jefferis">Gregory S X E. Jefferis</name></author><author><name sortKey="Koop, Mandy" sort="Koop, Mandy" uniqKey="Koop M" first="Mandy" last="Koop">Mandy Koop</name></author><author><name sortKey="Hill, Bruce C" sort="Hill, Bruce C" uniqKey="Hill B" first="Bruce C" last="Hill">Bruce C. Hill</name></author><author><name sortKey="Hastie, Trevor" sort="Hastie, Trevor" uniqKey="Hastie T" first="Trevor" last="Hastie">Trevor Hastie</name></author><author><name sortKey="Heit, Gary" sort="Heit, Gary" uniqKey="Heit G" first="Gary" last="Heit">Gary Heit</name></author><author><name sortKey="Bronte Stewart, Helen M" sort="Bronte Stewart, Helen M" uniqKey="Bronte Stewart H" first="Helen M" last="Bronte-Stewart">Helen M. Bronte-Stewart</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomechanical Phenomena</term><term>Brain (physiopathology)</term><term>Brain (surgery)</term><term>Deep Brain Stimulation (methods)</term><term>Disability Evaluation</term><term>Dopamine Agonists (therapeutic use)</term><term>Electrodes, Implanted</term><term>Electromyography (instrumentation)</term><term>Fingers (physiopathology)</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Middle Aged</term><term>Movement Disorders (diagnosis)</term><term>Movement Disorders (physiopathology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Periodicity</term><term>Postoperative Care</term><term>Preoperative Care</term><term>Questionnaires</term><term>Severity of Illness Index</term><term>User-Computer Interface</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Movement Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Fingers</term><term>Movement Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biomechanical Phenomena</term><term>Disability Evaluation</term><term>Electrodes, Implanted</term><term>Humans</term><term>Middle Aged</term><term>Periodicity</term><term>Postoperative Care</term><term>Preoperative Care</term><term>Questionnaires</term><term>Severity of Illness Index</term><term>User-Computer Interface</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Unified Parkinson's Disease Rating Scale (UPDRS) is the primary outcome measure in most clinical trials of Parkinson's disease (PD) therapeutics. Each subscore of the motor section (UPDRS III) compresses a wide range of motor performance into a coarse-grained scale from 0 to 4; the assessment of performance can also be subjective. Quantitative digitography (QDG) is an objective, quantitative assessment of digital motor control using a computer-interfaced musical keyboard. In this study, we show that the kinematics of a repetitive alternating finger-tapping (RAFT) task using QDG correlate with the UPDRS motor score, particularly with the bradykinesia subscore, in 33 patients with PD. We show that dopaminergic medication and an average of 9.5 months of bilateral subthalamic nucleus deep brain stimulation (B-STN DBS) significantly improve UPDRS and QDG scores but may have different effects on certain kinematic parameters. This study substantiates the use of QDG to measure motor outcome in trials of PD therapeutics and shows that medication and B-STN DBS both improve fine motor control.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16001401</PMID><DateCreated><Year>2005</Year><Month>10</Month><Day>11</Day></DateCreated><DateCompleted><Year>2006</Year><Month>02</Month><Day>16</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>10</Issue><PubDate><Year>2005</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Quantitative measurements of alternating finger tapping in Parkinson's disease correlate with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation.</ArticleTitle><Pagination><MedlinePgn>1286-98</MedlinePgn></Pagination><Abstract><AbstractText>The Unified Parkinson's Disease Rating Scale (UPDRS) is the primary outcome measure in most clinical trials of Parkinson's disease (PD) therapeutics. Each subscore of the motor section (UPDRS III) compresses a wide range of motor performance into a coarse-grained scale from 0 to 4; the assessment of performance can also be subjective. Quantitative digitography (QDG) is an objective, quantitative assessment of digital motor control using a computer-interfaced musical keyboard. In this study, we show that the kinematics of a repetitive alternating finger-tapping (RAFT) task using QDG correlate with the UPDRS motor score, particularly with the bradykinesia subscore, in 33 patients with PD. We show that dopaminergic medication and an average of 9.5 months of bilateral subthalamic nucleus deep brain stimulation (B-STN DBS) significantly improve UPDRS and QDG scores but may have different effects on certain kinematic parameters. 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UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010507">Periodicity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011182">Postoperative Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011300">Preoperative Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D011795">Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014584">User-Computer Interface</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>7</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>2</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>7</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.20556</ArticleId><ArticleId IdType="pubmed">16001401</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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