Surface electromyography shows increased mirroring in Parkinson's disease patients without overt mirror movements.
Identifieur interne : 002C28 ( PubMed/Corpus ); précédent : 002C27; suivant : 002C29Surface electromyography shows increased mirroring in Parkinson's disease patients without overt mirror movements.
Auteurs : Massimo Cincotta ; Fabio Giovannelli ; Alessandra Borgheresi ; Fabrizio Balestrieri ; Paola Vanni ; Aldo Ragazzoni ; Gaetano Zaccara ; Ulf ZiemannSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Basal Ganglia (drug effects), Basal Ganglia (physiopathology), Cerebral Cortex (drug effects), Cerebral Cortex (physiopathology), Dopamine Agonists (therapeutic use), Electromyography (drug effects), Female, Functional Laterality (drug effects), Functional Laterality (physiology), Humans, Isometric Contraction (drug effects), Isometric Contraction (physiology), Levodopa (therapeutic use), Male, Middle Aged, Nerve Net (drug effects), Nerve Net (physiopathology), Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Pyramidal Tracts (drug effects), Pyramidal Tracts (physiopathology), Reference Values.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agonists, Levodopa.
- diagnosis : Parkinson Disease.
- drug effects : Basal Ganglia, Cerebral Cortex, Electromyography, Functional Laterality, Isometric Contraction, Nerve Net, Pyramidal Tracts.
- drug therapy : Parkinson Disease.
- physiology : Functional Laterality, Isometric Contraction.
- physiopathology : Basal Ganglia, Cerebral Cortex, Nerve Net, Parkinson Disease, Pyramidal Tracts.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Reference Values.
Abstract
Patients with Parkinson's disease (PD) may present mirror movements (MM). Transcranial magnetic stimulation data indicate that these movements reflect an abnormal enhancement of the "physiological mirroring" that can be observed in healthy adults during complex and effortful tasks. It was hypothesized that, in PD, enhanced mirroring is caused by a failure of basal ganglia output to support the cortical network that is responsible for the execution of strictly unimanual movements. If so, it is likely that subtle alterations of voluntary unimanual motor control are also present in PD patients without overt MM. We tested this hypothesis by using surface electromyographic (EMG) techniques in 12 mildly to moderately affected PD patients without overt MM, and in 2 control groups (12 age-matched and 10 young healthy volunteers). Subjects performed unilateral phasic thumb abduction during a sustained tonic contraction of the opposite abductor pollicis brevis. All patients were tested on dopaminergic therapy. On a separate day, 7 of 12 patients were re-tested after withdrawal of medication. During this task, involuntary mirror-like increase in surface EMG of the tonically abducting thumb was significantly larger in PD patients than in age-matched or young healthy volunteers. Off therapy, mirroring was slightly greater than on medication, although this difference was not significant. Our findings suggest that dysfunction of unimanual motor control is a general feature of PD. It is likely that this deficient movement lateralization contributes to an impairment of nonsymmetrical bimanual movements in PD.
DOI: 10.1002/mds.20972
PubMed: 16705686
Links to Exploration step
pubmed:16705686Le document en format XML
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sortKey="Vanni, Paola" sort="Vanni, Paola" uniqKey="Vanni P" first="Paola" last="Vanni">Paola Vanni</name></author><author><name sortKey="Ragazzoni, Aldo" sort="Ragazzoni, Aldo" uniqKey="Ragazzoni A" first="Aldo" last="Ragazzoni">Aldo Ragazzoni</name></author><author><name sortKey="Zaccara, Gaetano" sort="Zaccara, Gaetano" uniqKey="Zaccara G" first="Gaetano" last="Zaccara">Gaetano Zaccara</name></author><author><name sortKey="Ziemann, Ulf" sort="Ziemann, Ulf" uniqKey="Ziemann U" first="Ulf" last="Ziemann">Ulf Ziemann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20972</idno><idno type="RBID">pubmed:16705686</idno><idno type="pmid">16705686</idno><idno type="wicri:Area/PubMed/Corpus">002C28</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Surface electromyography shows increased mirroring in Parkinson's disease patients without overt mirror movements.</title><author><name sortKey="Cincotta, Massimo" sort="Cincotta, Massimo" uniqKey="Cincotta M" first="Massimo" last="Cincotta">Massimo Cincotta</name><affiliation><nlm:affiliation>Unit of Neurology, Santa Maria Nuova Hospital, Florence, Italy. cincotta@unifi.it</nlm:affiliation></affiliation></author><author><name sortKey="Giovannelli, Fabio" sort="Giovannelli, Fabio" uniqKey="Giovannelli F" first="Fabio" last="Giovannelli">Fabio Giovannelli</name></author><author><name sortKey="Borgheresi, Alessandra" sort="Borgheresi, Alessandra" uniqKey="Borgheresi A" first="Alessandra" last="Borgheresi">Alessandra Borgheresi</name></author><author><name sortKey="Balestrieri, Fabrizio" sort="Balestrieri, Fabrizio" uniqKey="Balestrieri F" first="Fabrizio" last="Balestrieri">Fabrizio Balestrieri</name></author><author><name sortKey="Vanni, Paola" sort="Vanni, Paola" uniqKey="Vanni P" first="Paola" last="Vanni">Paola Vanni</name></author><author><name sortKey="Ragazzoni, Aldo" sort="Ragazzoni, Aldo" uniqKey="Ragazzoni A" first="Aldo" last="Ragazzoni">Aldo Ragazzoni</name></author><author><name sortKey="Zaccara, Gaetano" sort="Zaccara, Gaetano" uniqKey="Zaccara G" first="Gaetano" last="Zaccara">Gaetano Zaccara</name></author><author><name sortKey="Ziemann, Ulf" sort="Ziemann, Ulf" uniqKey="Ziemann U" first="Ulf" last="Ziemann">Ulf Ziemann</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents (therapeutic use)</term><term>Basal Ganglia (drug effects)</term><term>Basal Ganglia (physiopathology)</term><term>Cerebral Cortex (drug effects)</term><term>Cerebral Cortex (physiopathology)</term><term>Dopamine Agonists 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Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) may present mirror movements (MM). Transcranial magnetic stimulation data indicate that these movements reflect an abnormal enhancement of the "physiological mirroring" that can be observed in healthy adults during complex and effortful tasks. It was hypothesized that, in PD, enhanced mirroring is caused by a failure of basal ganglia output to support the cortical network that is responsible for the execution of strictly unimanual movements. If so, it is likely that subtle alterations of voluntary unimanual motor control are also present in PD patients without overt MM. We tested this hypothesis by using surface electromyographic (EMG) techniques in 12 mildly to moderately affected PD patients without overt MM, and in 2 control groups (12 age-matched and 10 young healthy volunteers). Subjects performed unilateral phasic thumb abduction during a sustained tonic contraction of the opposite abductor pollicis brevis. All patients were tested on dopaminergic therapy. On a separate day, 7 of 12 patients were re-tested after withdrawal of medication. During this task, involuntary mirror-like increase in surface EMG of the tonically abducting thumb was significantly larger in PD patients than in age-matched or young healthy volunteers. Off therapy, mirroring was slightly greater than on medication, although this difference was not significant. Our findings suggest that dysfunction of unimanual motor control is a general feature of PD. It is likely that this deficient movement lateralization contributes to an impairment of nonsymmetrical bimanual movements in PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16705686</PMID><DateCreated><Year>2006</Year><Month>09</Month><Day>27</Day></DateCreated><DateCompleted><Year>2007</Year><Month>02</Month><Day>02</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>9</Issue><PubDate><Year>2006</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Surface electromyography shows increased mirroring in Parkinson's disease patients without overt mirror movements.</ArticleTitle><Pagination><MedlinePgn>1461-5</MedlinePgn></Pagination><Abstract><AbstractText>Patients with Parkinson's disease (PD) may present mirror movements (MM). Transcranial magnetic stimulation data indicate that these movements reflect an abnormal enhancement of the "physiological mirroring" that can be observed in healthy adults during complex and effortful tasks. It was hypothesized that, in PD, enhanced mirroring is caused by a failure of basal ganglia output to support the cortical network that is responsible for the execution of strictly unimanual movements. If so, it is likely that subtle alterations of voluntary unimanual motor control are also present in PD patients without overt MM. We tested this hypothesis by using surface electromyographic (EMG) techniques in 12 mildly to moderately affected PD patients without overt MM, and in 2 control groups (12 age-matched and 10 young healthy volunteers). Subjects performed unilateral phasic thumb abduction during a sustained tonic contraction of the opposite abductor pollicis brevis. All patients were tested on dopaminergic therapy. On a separate day, 7 of 12 patients were re-tested after withdrawal of medication. During this task, involuntary mirror-like increase in surface EMG of the tonically abducting thumb was significantly larger in PD patients than in age-matched or young healthy volunteers. Off therapy, mirroring was slightly greater than on medication, although this difference was not significant. Our findings suggest that dysfunction of unimanual motor control is a general feature of PD. It is likely that this deficient movement lateralization contributes to an impairment of nonsymmetrical bimanual movements in PD.</AbstractText><CopyrightInformation>(c) 2006 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cincotta</LastName><ForeName>Massimo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unit of Neurology, Santa Maria Nuova Hospital, Florence, Italy. cincotta@unifi.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giovannelli</LastName><ForeName>Fabio</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Borgheresi</LastName><ForeName>Alessandra</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Balestrieri</LastName><ForeName>Fabrizio</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Vanni</LastName><ForeName>Paola</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Ragazzoni</LastName><ForeName>Aldo</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Zaccara</LastName><ForeName>Gaetano</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Ziemann</LastName><ForeName>Ulf</ForeName><Initials>U</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018491">Dopamine Agonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000978">Antiparkinson Agents</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001479">Basal Ganglia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002540">Cerebral Cortex</DescriptorName><QualifierName MajorTopicYN="N" 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UI="D007537">Isometric Contraction</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007980">Levodopa</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009415">Nerve Net</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011712">Pyramidal Tracts</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012016">Reference Values</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>5</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>2</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>5</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.20972</ArticleId><ArticleId IdType="pubmed">16705686</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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