New developments of brain imaging for Parkinson's disease and related disorders.
Identifieur interne : 002B44 ( PubMed/Corpus ); précédent : 002B43; suivant : 002B45New developments of brain imaging for Parkinson's disease and related disorders.
Auteurs : Paola Piccini ; David J. BrooksSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Parkinson Disease, Parkinsonian Disorders.
- methods : Diagnostic Imaging.
- pathology : Blood-Brain Barrier, Microglia, Parkinson Disease, Parkinsonian Disorders.
- Brain Mapping, Humans.
Abstract
Parkinson's disease (PD) and related disorders are subcortical degenerations targeting the nigrostriatal dopaminergic system and basal ganglia. Traditionally, MRI has been used to detect structural and positron emission tomography and single emission computed tomography functional neurochemical and metabolic changes associated with these disorders. Recently, advances in diffusion-weighted MRI, ultrasonography, and radiotracer-based imaging have yielded greater sensitivity for revealing structural change and allowed detection of changes in brain dopamine levels after levodopa and during behavioral tasks. This review focuses on these recent advances in neuroimaging technology and their use for the diagnosis and assessment of PD and other parkinsonian disorders.
DOI: 10.1002/mds.20845
PubMed: 16874751
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pubmed:16874751Le document en format XML
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<author><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name>
<affiliation><nlm:affiliation>MRC Clinical Sciences Centre and Division of Neuroscience and Mental Health, Imperial College, Hammersmith Hospital, London, United Kingdom. paola.piccini@csc.mrc.ac.uk</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name>
</author>
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<author><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name>
<affiliation><nlm:affiliation>MRC Clinical Sciences Centre and Division of Neuroscience and Mental Health, Imperial College, Hammersmith Hospital, London, United Kingdom. paola.piccini@csc.mrc.ac.uk</nlm:affiliation>
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<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<imprint><date when="2006" type="published">2006</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood-Brain Barrier (pathology)</term>
<term>Brain Mapping</term>
<term>Diagnostic Imaging (methods)</term>
<term>Humans</term>
<term>Microglia (pathology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinsonian Disorders (diagnosis)</term>
<term>Parkinsonian Disorders (pathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
<term>Parkinsonian Disorders</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diagnostic Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Blood-Brain Barrier</term>
<term>Microglia</term>
<term>Parkinson Disease</term>
<term>Parkinsonian Disorders</term>
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<keywords scheme="MESH" xml:lang="en"><term>Brain Mapping</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) and related disorders are subcortical degenerations targeting the nigrostriatal dopaminergic system and basal ganglia. Traditionally, MRI has been used to detect structural and positron emission tomography and single emission computed tomography functional neurochemical and metabolic changes associated with these disorders. Recently, advances in diffusion-weighted MRI, ultrasonography, and radiotracer-based imaging have yielded greater sensitivity for revealing structural change and allowed detection of changes in brain dopamine levels after levodopa and during behavioral tasks. This review focuses on these recent advances in neuroimaging technology and their use for the diagnosis and assessment of PD and other parkinsonian disorders.</div>
</front>
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<JournalIssue CitedMedium="Print"><Volume>21</Volume>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>New developments of brain imaging for Parkinson's disease and related disorders.</ArticleTitle>
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<Abstract><AbstractText>Parkinson's disease (PD) and related disorders are subcortical degenerations targeting the nigrostriatal dopaminergic system and basal ganglia. Traditionally, MRI has been used to detect structural and positron emission tomography and single emission computed tomography functional neurochemical and metabolic changes associated with these disorders. Recently, advances in diffusion-weighted MRI, ultrasonography, and radiotracer-based imaging have yielded greater sensitivity for revealing structural change and allowed detection of changes in brain dopamine levels after levodopa and during behavioral tasks. This review focuses on these recent advances in neuroimaging technology and their use for the diagnosis and assessment of PD and other parkinsonian disorders.</AbstractText>
<CopyrightInformation>Copyright 2006 Movement Disorder Society.</CopyrightInformation>
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<AffiliationInfo><Affiliation>MRC Clinical Sciences Centre and Division of Neuroscience and Mental Health, Imperial College, Hammersmith Hospital, London, United Kingdom. paola.piccini@csc.mrc.ac.uk</Affiliation>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020734">Parkinsonian Disorders</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName>
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