MovDisordV3, PubMed, Corpus, bibRecord, 002A94

NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach.

Identifieur interne : 002A94 ( PubMed/Corpus ); précédent : 002A93; suivant : 002A95

NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach.

Auteurs : Daniel G. Healy ; Patrick M. Abou-Sleiman ; Kourosh R. Ahmadi ; Sonia Gandhi ; Miratul M. Muqit ; Kailash P. Bhatia ; Niall P. Quinn ; Andrew J. Lees ; Janice L. Holton ; Tamas Revesz ; Nicholas W. Wood

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.

RBID : pubmed:16977628

English descriptors

KwdEn :
- Case-Control Studies, Chi-Square Distribution, DNA-Binding Proteins (genetics), Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Male, Middle Aged, Nuclear Receptor Subfamily 4, Group A, Member 2, Parkinson Disease (genetics), Transcription Factors (genetics).
MESH :
- chemical , genetics : DNA-Binding Proteins, Transcription Factors.
- genetics : Parkinson Disease.
- Case-Control Studies, Chi-Square Distribution, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Male, Middle Aged, Nuclear Receptor Subfamily 4, Group A, Member 2.

Abstract

The NR4A2 gene, which may cause autosomal dominant Parkinson's disease (PD), has also been reported to be a susceptibility factor for sporadic PD. Here, we use a haplotype-tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population.

DOI: 10.1002/mds.21018
PubMed: 16977628

Links to Exploration step

pubmed:16977628

Le document en format XML

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<author><name sortKey="Healy, Daniel G" sort="Healy, Daniel G" uniqKey="Healy D" first="Daniel G" last="Healy">Daniel G. Healy</name>
<affiliation><nlm:affiliation>Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom. d.healy@ion.ucl.ac.uk</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Abou Sleiman, Patrick M" sort="Abou Sleiman, Patrick M" uniqKey="Abou Sleiman P" first="Patrick M" last="Abou-Sleiman">Patrick M. Abou-Sleiman</name>
</author>
<author><name sortKey="Ahmadi, Kourosh R" sort="Ahmadi, Kourosh R" uniqKey="Ahmadi K" first="Kourosh R" last="Ahmadi">Kourosh R. Ahmadi</name>
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<author><name sortKey="Gandhi, Sonia" sort="Gandhi, Sonia" uniqKey="Gandhi S" first="Sonia" last="Gandhi">Sonia Gandhi</name>
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<author><name sortKey="Muqit, Miratul M" sort="Muqit, Miratul M" uniqKey="Muqit M" first="Miratul M" last="Muqit">Miratul M. Muqit</name>
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<author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P" last="Bhatia">Kailash P. Bhatia</name>
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<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P" last="Quinn">Niall P. Quinn</name>
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<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name>
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<author><name sortKey="Holton, Janice L" sort="Holton, Janice L" uniqKey="Holton J" first="Janice L" last="Holton">Janice L. Holton</name>
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<author><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name>
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<author><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W" last="Wood">Nicholas W. Wood</name>
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<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genetic Variation</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
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<term>Chi-Square Distribution</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genetic Variation</term>
<term>Genotype</term>
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<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">The NR4A2 gene, which may cause autosomal dominant Parkinson's disease (PD), has also been reported to be a susceptibility factor for sporadic PD. Here, we use a haplotype-tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach.

NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki