Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes.
Identifieur interne : 002527 ( PubMed/Corpus ); précédent : 002526; suivant : 002528Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes.
Auteurs : Claudia Schmidt ; Birgit Herting ; Silke Prieur ; Susann Junghanns ; Katherine Schweitzer ; Christoph Globas ; Ludger Schöls ; Sabine Antoni ; Dietmar Ferger ; Heinz Reichmann ; Helmut Wilhelm ; Daniela Berg ; Tjalf ZiemssenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- complications : Multiple System Atrophy, Parkinson Disease.
- etiology : Supranuclear Palsy, Progressive.
- pathology : Supranuclear Palsy, Progressive.
- physiology : Pupil.
- Aged, Case-Control Studies, Darkness, Female, Humans, Male, Middle Aged.
Abstract
The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes.
DOI: 10.1002/mds.21721
PubMed: 17853484
Links to Exploration step
pubmed:17853484Le document en format XML
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<author><name sortKey="Schmidt, Claudia" sort="Schmidt, Claudia" uniqKey="Schmidt C" first="Claudia" last="Schmidt">Claudia Schmidt</name>
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<author><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes.</title>
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<term>Male</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (complications)</term>
<term>Parkinson Disease (complications)</term>
<term>Pupil (physiology)</term>
<term>Supranuclear Palsy, Progressive (etiology)</term>
<term>Supranuclear Palsy, Progressive (pathology)</term>
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<term>Case-Control Studies</term>
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<front><div type="abstract" xml:lang="en">The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes.</div>
</front>
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<ArticleTitle>Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes.</ArticleTitle>
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<Abstract><AbstractText>The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes.</AbstractText>
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