MovDisordV3, PubMed, Corpus, bibRecord, 002476

Radiotherapy to the salivary glands as treatment of sialorrhea in patients with parkinsonism.

Identifieur interne : 002476 ( PubMed/Corpus ); précédent : 002475; suivant : 002477

Radiotherapy to the salivary glands as treatment of sialorrhea in patients with parkinsonism.

Auteurs : Anna-Gerlind Postma ; Mart Heesters ; Teus Van Laar

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.

RBID : pubmed:17960826

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (psychology), Prospective Studies, Quality of Life, Questionnaires, Radiotherapy (adverse effects), Salivary Glands, Sialorrhea (etiology), Sialorrhea (psychology), Sialorrhea (radiotherapy), Treatment Outcome.
MESH :
- adverse effects : Radiotherapy.
- complications : Parkinson Disease.
- etiology : Sialorrhea.
- psychology : Parkinson Disease, Sialorrhea.
- radiotherapy : Sialorrhea.
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Female, Humans, Male, Middle Aged, Prospective Studies, Quality of Life, Questionnaires, Salivary Glands, Treatment Outcome.

Abstract

This study investigated retrospectively the long-term efficacy and safety of radiotherapy (RT) to the major salivary glands as treatment of sialorrhea in patients with parkinsonism. Twenty-eight patients received a bilateral dose of 12 Gy to the parotid and part of the submandibular glands between 2001 and 2006. Severity of sialorrhea and adverse events were assessed at 1 and 6 months post-RT and finally in the first quarter of 2007. Item 6 of the activities of daily living-section of the Unified Parkinson's Disease Rating Scale was used as primary endpoint. Quality of life (QoL) pre- and post-RT was investigated using a shortened Parkinson's Disease Questionnaire-8. Sialorrhea had improved significantly at 1 month post-RT and this effect was maintained for at least 1 year. Most frequent adverse events were loss of taste and a dry mouth; however, 75% of these adverse events were transient. QoL had improved significantly on the long term. The clinical global impression scores at the final follow-up showed that 80% of patients were satisfied. It was concluded that RT is an effective and safe treatment of sialorrhea on the long term in patients with parkinsonism.

DOI: 10.1002/mds.21752
PubMed: 17960826

Links to Exploration step

pubmed:17960826

Le document en format XML

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<author><name sortKey="Postma, Anna Gerlind" sort="Postma, Anna Gerlind" uniqKey="Postma A" first="Anna-Gerlind" last="Postma">Anna-Gerlind Postma</name>
<affiliation><nlm:affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Heesters, Mart" sort="Heesters, Mart" uniqKey="Heesters M" first="Mart" last="Heesters">Mart Heesters</name>
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<author><name sortKey="Van Laar, Teus" sort="Van Laar, Teus" uniqKey="Van Laar T" first="Teus" last="Van Laar">Teus Van Laar</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Radiotherapy to the salivary glands as treatment of sialorrhea in patients with parkinsonism.</title>
<author><name sortKey="Postma, Anna Gerlind" sort="Postma, Anna Gerlind" uniqKey="Postma A" first="Anna-Gerlind" last="Postma">Anna-Gerlind Postma</name>
<affiliation><nlm:affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation>
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<author><name sortKey="Heesters, Mart" sort="Heesters, Mart" uniqKey="Heesters M" first="Mart" last="Heesters">Mart Heesters</name>
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<author><name sortKey="Van Laar, Teus" sort="Van Laar, Teus" uniqKey="Van Laar T" first="Teus" last="Van Laar">Teus Van Laar</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (psychology)</term>
<term>Prospective Studies</term>
<term>Quality of Life</term>
<term>Questionnaires</term>
<term>Radiotherapy (adverse effects)</term>
<term>Salivary Glands</term>
<term>Sialorrhea (etiology)</term>
<term>Sialorrhea (psychology)</term>
<term>Sialorrhea (radiotherapy)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radiotherapy</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Sialorrhea</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term>
<term>Sialorrhea</term>
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<term>Aged</term>
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<front><div type="abstract" xml:lang="en">This study investigated retrospectively the long-term efficacy and safety of radiotherapy (RT) to the major salivary glands as treatment of sialorrhea in patients with parkinsonism. Twenty-eight patients received a bilateral dose of 12 Gy to the parotid and part of the submandibular glands between 2001 and 2006. Severity of sialorrhea and adverse events were assessed at 1 and 6 months post-RT and finally in the first quarter of 2007. Item 6 of the activities of daily living-section of the Unified Parkinson's Disease Rating Scale was used as primary endpoint. Quality of life (QoL) pre- and post-RT was investigated using a shortened Parkinson's Disease Questionnaire-8. Sialorrhea had improved significantly at 1 month post-RT and this effect was maintained for at least 1 year. Most frequent adverse events were loss of taste and a dry mouth; however, 75% of these adverse events were transient. QoL had improved significantly on the long term. The clinical global impression scores at the final follow-up showed that 80% of patients were satisfied. It was concluded that RT is an effective and safe treatment of sialorrhea on the long term in patients with parkinsonism.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17960826</PMID>
<DateCreated><Year>2007</Year>
<Month>12</Month>
<Day>27</Day>
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<DateCompleted><Year>2008</Year>
<Month>02</Month>
<Day>20</Day>
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<JournalIssue CitedMedium="Print"><Volume>22</Volume>
<Issue>16</Issue>
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<Month>Dec</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Radiotherapy to the salivary glands as treatment of sialorrhea in patients with parkinsonism.</ArticleTitle>
<Pagination><MedlinePgn>2430-5</MedlinePgn>
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<Abstract><AbstractText>This study investigated retrospectively the long-term efficacy and safety of radiotherapy (RT) to the major salivary glands as treatment of sialorrhea in patients with parkinsonism. Twenty-eight patients received a bilateral dose of 12 Gy to the parotid and part of the submandibular glands between 2001 and 2006. Severity of sialorrhea and adverse events were assessed at 1 and 6 months post-RT and finally in the first quarter of 2007. Item 6 of the activities of daily living-section of the Unified Parkinson's Disease Rating Scale was used as primary endpoint. Quality of life (QoL) pre- and post-RT was investigated using a shortened Parkinson's Disease Questionnaire-8. Sialorrhea had improved significantly at 1 month post-RT and this effect was maintained for at least 1 year. Most frequent adverse events were loss of taste and a dry mouth; however, 75% of these adverse events were transient. QoL had improved significantly on the long term. The clinical global impression scores at the final follow-up showed that 80% of patients were satisfied. It was concluded that RT is an effective and safe treatment of sialorrhea on the long term in patients with parkinsonism.</AbstractText>
<CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation>
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<AffiliationInfo><Affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.</Affiliation>
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<QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011446">Prospective Studies</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011878">Radiotherapy</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012469">Salivary Glands</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012798">Sialorrhea</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000532">radiotherapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year>
<Month>10</Month>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Radiotherapy to the salivary glands as treatment of sialorrhea in patients with parkinsonism.

Radiotherapy to the salivary glands as treatment of sialorrhea in patients with parkinsonism.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki