Anhidrosis in multiple system atrophy: a preganglionic sudomotor dysfunction?
Identifieur interne : 002292 ( PubMed/Corpus ); précédent : 002291; suivant : 002293Anhidrosis in multiple system atrophy: a preganglionic sudomotor dysfunction?
Auteurs : Vincenzo Donadio ; Maria Nolano ; Mikael Elam ; Pasquale Montagna ; Vincenzo Provitera ; Enrico Bugiardini ; Agostino Baruzzi ; Lucio Santoro ; Rocco LiguoriSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Autonomic Fibers, Postganglionic (physiopathology), Autonomic Nervous System Diseases (physiopathology), Humans, Hypohidrosis (etiology), Male, Middle Aged, Multiple System Atrophy (physiopathology), Sympathetic Fibers, Postganglionic (physiopathology), Sympathetic Nervous System (physiopathology).
- MESH :
- etiology : Hypohidrosis.
- physiopathology : Autonomic Fibers, Postganglionic, Autonomic Nervous System Diseases, Multiple System Atrophy, Sympathetic Fibers, Postganglionic, Sympathetic Nervous System.
- Aged, Humans, Male, Middle Aged.
Abstract
Anhidrosis occurs in the majority of multiple system atrophy (MSA) patients but the underlying site of lesion is not well established. We describe three patients with long-standing MSA and anhidrosis diagnosed on the basis of a thermoregulatory sweating test. In biopsies of anhidrotic skin, immunofluorescence analysis disclosed a well preserved postganglionic sudomotor innervation in all three patients supporting the hypothesis of a preganglionic nerve fiber lesion underlying their anhidrosis. Postganglionic sudomotor fiber integrity was also confirmed by normal electrodermal responses in one patient, whereas such responses and microneurographically detectable skin sympathetic nerve activity were absent in the other two MSA patients, suggesting a functional inactivity of structurally intact postganglionic sympathetic skin fibers.
DOI: 10.1002/mds.21972
PubMed: 18361470
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pubmed:18361470Le document en format XML
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Foscolo 7, Bologna, Italy. donadio@neuro.unibo.it</nlm:affiliation></affiliation></author><author><name sortKey="Nolano, Maria" sort="Nolano, Maria" uniqKey="Nolano M" first="Maria" last="Nolano">Maria Nolano</name></author><author><name sortKey="Elam, Mikael" sort="Elam, Mikael" uniqKey="Elam M" first="Mikael" last="Elam">Mikael Elam</name></author><author><name sortKey="Montagna, Pasquale" sort="Montagna, Pasquale" uniqKey="Montagna P" first="Pasquale" last="Montagna">Pasquale Montagna</name></author><author><name sortKey="Provitera, Vincenzo" sort="Provitera, Vincenzo" uniqKey="Provitera V" first="Vincenzo" last="Provitera">Vincenzo Provitera</name></author><author><name sortKey="Bugiardini, Enrico" sort="Bugiardini, Enrico" uniqKey="Bugiardini E" first="Enrico" last="Bugiardini">Enrico Bugiardini</name></author><author><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name></author><author><name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name></author><author><name sortKey="Liguori, Rocco" sort="Liguori, Rocco" uniqKey="Liguori R" first="Rocco" last="Liguori">Rocco Liguori</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.21972</idno><idno type="RBID">pubmed:18361470</idno><idno type="pmid">18361470</idno><idno type="wicri:Area/PubMed/Corpus">002292</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Anhidrosis in multiple system atrophy: a preganglionic sudomotor dysfunction?</title><author><name sortKey="Donadio, Vincenzo" sort="Donadio, Vincenzo" uniqKey="Donadio V" first="Vincenzo" last="Donadio">Vincenzo Donadio</name><affiliation><nlm:affiliation>Department of Neurological Sciences, University of Bologna, Via U. 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We describe three patients with long-standing MSA and anhidrosis diagnosed on the basis of a thermoregulatory sweating test. In biopsies of anhidrotic skin, immunofluorescence analysis disclosed a well preserved postganglionic sudomotor innervation in all three patients supporting the hypothesis of a preganglionic nerve fiber lesion underlying their anhidrosis. Postganglionic sudomotor fiber integrity was also confirmed by normal electrodermal responses in one patient, whereas such responses and microneurographically detectable skin sympathetic nerve activity were absent in the other two MSA patients, suggesting a functional inactivity of structurally intact postganglionic sympathetic skin fibers.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18361470</PMID><DateCreated><Year>2008</Year><Month>05</Month><Day>01</Day></DateCreated><DateCompleted><Year>2008</Year><Month>08</Month><Day>06</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>6</Issue><PubDate><Year>2008</Year><Month>Apr</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Anhidrosis in multiple system atrophy: a preganglionic sudomotor dysfunction?</ArticleTitle><Pagination><MedlinePgn>885-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.21972</ELocationID><Abstract><AbstractText>Anhidrosis occurs in the majority of multiple system atrophy (MSA) patients but the underlying site of lesion is not well established. We describe three patients with long-standing MSA and anhidrosis diagnosed on the basis of a thermoregulatory sweating test. In biopsies of anhidrotic skin, immunofluorescence analysis disclosed a well preserved postganglionic sudomotor innervation in all three patients supporting the hypothesis of a preganglionic nerve fiber lesion underlying their anhidrosis. Postganglionic sudomotor fiber integrity was also confirmed by normal electrodermal responses in one patient, whereas such responses and microneurographically detectable skin sympathetic nerve activity were absent in the other two MSA patients, suggesting a functional inactivity of structurally intact postganglionic sympathetic skin fibers.</AbstractText><CopyrightInformation>(c) 2008 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Donadio</LastName><ForeName>Vincenzo</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences, University of Bologna, Via U. Foscolo 7, Bologna, Italy. donadio@neuro.unibo.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nolano</LastName><ForeName>Maria</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Elam</LastName><ForeName>Mikael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Montagna</LastName><ForeName>Pasquale</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Provitera</LastName><ForeName>Vincenzo</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Bugiardini</LastName><ForeName>Enrico</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Baruzzi</LastName><ForeName>Agostino</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Santoro</LastName><ForeName>Lucio</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Liguori</LastName><ForeName>Rocco</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001338">Autonomic Fibers, Postganglionic</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001342">Autonomic Nervous System Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007007">Hypohidrosis</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019578">Multiple System Atrophy</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017779">Sympathetic Fibers, Postganglionic</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013564">Sympathetic Nervous System</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>3</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>8</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>3</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21972</ArticleId><ArticleId IdType="pubmed">18361470</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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