The role of gait rhythmicity and bilateral coordination of stepping in the pathophysiology of freezing of gait in Parkinson's disease.
Identifieur interne : 002122 ( PubMed/Corpus ); précédent : 002121; suivant : 002123The role of gait rhythmicity and bilateral coordination of stepping in the pathophysiology of freezing of gait in Parkinson's disease.
Auteurs : Meir Plotnik ; Jeffrey M. HausdorffSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- physiology : Functional Laterality, Gait, Psychomotor Performance.
- physiopathology : Parkinson Disease.
- Humans, Periodicity, Walking.
Abstract
Freezing of gait (FOG) is a disabling episodic gait disturbance that is common among patients with Parkinson's disease (PD). In this review, we describe a new approach for understanding the mechanisms underlying this puzzling phenomenon. We propose that impairments in the ongoing regulation of gait, even during periods in which freezing is not present, set the stage for the occurrence of a FOG episode. More specifically, three "interictal" walking attributes are associated with FOG: gait rhythmicity, gait asymmetry, and bilateral dyscoordination of left-right stepping. Gait is less rhythmic, more asymmetric, and less coordinated among PD patients with FOG, when compared with PD patients without FOG. We describe the relationship between these changes and other features of patients with FOG and discuss whether these gait changes may predispose to FOG or if they also cause FOG, perhaps, when they are altered beyond a certain threshold or exacerbated by another trigger.
DOI: 10.1002/mds.21984
PubMed: 18668626
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pubmed:18668626Le document en format XML
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Hausdorff</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.21984</idno><idno type="RBID">pubmed:18668626</idno><idno type="pmid">18668626</idno><idno type="wicri:Area/PubMed/Corpus">002122</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The role of gait rhythmicity and bilateral coordination of stepping in the pathophysiology of freezing of gait in Parkinson's disease.</title><author><name sortKey="Plotnik, Meir" sort="Plotnik, Meir" uniqKey="Plotnik M" first="Meir" last="Plotnik">Meir Plotnik</name><affiliation><nlm:affiliation>Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel. meirp@tasmc.health.gov.il</nlm:affiliation></affiliation></author><author><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M" last="Hausdorff">Jeffrey M. Hausdorff</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Functional Laterality (physiology)</term><term>Gait (physiology)</term><term>Humans</term><term>Parkinson Disease (physiopathology)</term><term>Periodicity</term><term>Psychomotor Performance (physiology)</term><term>Walking</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term><term>Gait</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Periodicity</term><term>Walking</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Freezing of gait (FOG) is a disabling episodic gait disturbance that is common among patients with Parkinson's disease (PD). In this review, we describe a new approach for understanding the mechanisms underlying this puzzling phenomenon. We propose that impairments in the ongoing regulation of gait, even during periods in which freezing is not present, set the stage for the occurrence of a FOG episode. More specifically, three "interictal" walking attributes are associated with FOG: gait rhythmicity, gait asymmetry, and bilateral dyscoordination of left-right stepping. Gait is less rhythmic, more asymmetric, and less coordinated among PD patients with FOG, when compared with PD patients without FOG. We describe the relationship between these changes and other features of patients with FOG and discuss whether these gait changes may predispose to FOG or if they also cause FOG, perhaps, when they are altered beyond a certain threshold or exacerbated by another trigger.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18668626</PMID><DateCreated><Year>2008</Year><Month>08</Month><Day>05</Day></DateCreated><DateCompleted><Year>2008</Year><Month>12</Month><Day>22</Day></DateCompleted><DateRevised><Year>2009</Year><Month>04</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>23 Suppl 2</Volume><PubDate><Year>2008</Year></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>The role of gait rhythmicity and bilateral coordination of stepping in the pathophysiology of freezing of gait in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>S444-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.21984</ELocationID><Abstract><AbstractText>Freezing of gait (FOG) is a disabling episodic gait disturbance that is common among patients with Parkinson's disease (PD). In this review, we describe a new approach for understanding the mechanisms underlying this puzzling phenomenon. We propose that impairments in the ongoing regulation of gait, even during periods in which freezing is not present, set the stage for the occurrence of a FOG episode. More specifically, three "interictal" walking attributes are associated with FOG: gait rhythmicity, gait asymmetry, and bilateral dyscoordination of left-right stepping. Gait is less rhythmic, more asymmetric, and less coordinated among PD patients with FOG, when compared with PD patients without FOG. We describe the relationship between these changes and other features of patients with FOG and discuss whether these gait changes may predispose to FOG or if they also cause FOG, perhaps, when they are altered beyond a certain threshold or exacerbated by another trigger.</AbstractText><CopyrightInformation>(c) 2008 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Plotnik</LastName><ForeName>Meir</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel. meirp@tasmc.health.gov.il</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hausdorff</LastName><ForeName>Jeffrey M</ForeName><Initials>JM</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AG-08812</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AG-14100</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HD-39838</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RR-13622</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Mov Disord. 2008 Aug 15;23(11):1639-40</RefSource></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007839">Functional Laterality</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005684">Gait</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D010507">Periodicity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011597">Psychomotor Performance</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016138">Walking</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>34</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>8</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>12</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>8</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21984</ArticleId><ArticleId IdType="pubmed">18668626</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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