Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses.
Identifieur interne : 001F63 ( PubMed/Corpus ); précédent : 001F62; suivant : 001F64Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses.
Auteurs : Hee K. Park ; Jae S. Kim ; Ki C. Im ; Seung J. Oh ; Mi J. Kim ; Jae-Hong Lee ; Sun J. Chung ; Myoung C. LeeSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Basal Ganglia Diseases (complications), Basal Ganglia Diseases (metabolism), Basal Ganglia Diseases (radionuclide imaging), Brain (metabolism), Brain (pathology), Brain (radionuclide imaging), Carbon Radioisotopes (diagnostic use), Female, Fluorine Radioisotopes (diagnostic use), Fluorodeoxyglucose F18 (diagnostic use), Gait Disorders, Neurologic (etiology), Gait Disorders, Neurologic (metabolism), Gait Disorders, Neurologic (radionuclide imaging), Glucose (metabolism), Humans, Hypokinesia (etiology), Hypokinesia (metabolism), Hypokinesia (radionuclide imaging), Iodine Radioisotopes (diagnostic use), Magnetic Resonance Imaging, Male, Mesencephalon (metabolism), Mesencephalon (radionuclide imaging), Middle Aged, Parkinson Disease (complications), Parkinson Disease (radionuclide imaging), Positron-Emission Tomography, Radiopharmaceuticals (diagnostic use), Supranuclear Palsy, Progressive (complications), Supranuclear Palsy, Progressive (radionuclide imaging), Tropanes (diagnostic use).
- MESH :
- chemical , diagnostic use : Carbon Radioisotopes, Fluorine Radioisotopes, Fluorodeoxyglucose F18, Iodine Radioisotopes, Radiopharmaceuticals, Tropanes.
- complications : Basal Ganglia Diseases, Parkinson Disease, Supranuclear Palsy, Progressive.
- etiology : Gait Disorders, Neurologic, Hypokinesia.
- metabolism : Basal Ganglia Diseases, Brain, Gait Disorders, Neurologic, Glucose, Hypokinesia, Mesencephalon.
- pathology : Brain.
- radionuclide imaging : Basal Ganglia Diseases, Brain, Gait Disorders, Neurologic, Hypokinesia, Mesencephalon, Parkinson Disease, Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography.
Abstract
Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [(18)F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [(18)F] N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane (FP-CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP-CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated.
DOI: 10.1002/mds.22347
PubMed: 18951539
Links to Exploration step
pubmed:18951539Le document en format XML
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<term>Basal Ganglia Diseases (radionuclide imaging)</term>
<term>Brain (metabolism)</term>
<term>Brain (pathology)</term>
<term>Brain (radionuclide imaging)</term>
<term>Carbon Radioisotopes (diagnostic use)</term>
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<term>Fluorine Radioisotopes (diagnostic use)</term>
<term>Fluorodeoxyglucose F18 (diagnostic use)</term>
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<term>Gait Disorders, Neurologic (metabolism)</term>
<term>Gait Disorders, Neurologic (radionuclide imaging)</term>
<term>Glucose (metabolism)</term>
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<term>Iodine Radioisotopes (diagnostic use)</term>
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<term>Mesencephalon (metabolism)</term>
<term>Mesencephalon (radionuclide imaging)</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
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<term>Radiopharmaceuticals (diagnostic use)</term>
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<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
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<front><div type="abstract" xml:lang="en">Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [(18)F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [(18)F] N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane (FP-CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP-CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated.</div>
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<Abstract><AbstractText>Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [(18)F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [(18)F] N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane (FP-CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP-CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated.</AbstractText>
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