Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys.
Identifieur interne : 001D30 ( PubMed/Corpus ); précédent : 001D29; suivant : 001D31Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys.
Auteurs : Carine Karachi ; David Grabli ; Nicolas Baup ; Stéphanie Mounayar ; Dominique Tandé ; Chantal François ; Etienne C. HirschSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Animals, Behavior, Animal (drug effects), Bicuculline (adverse effects), Cercopithecus aethiops, Disease Models, Animal, Functional Laterality (drug effects), GABA Agents (adverse effects), Globus Pallidus (drug effects), Globus Pallidus (physiology), Male, Microinjections (methods), Movement Disorders (etiology), Movement Disorders (pathology), Muscimol (adverse effects), Reaction Time (drug effects), Stereotyped Behavior (drug effects), Stereotyped Behavior (physiology), Subthalamic Nucleus (drug effects), Subthalamic Nucleus (physiopathology).
- MESH :
- chemical , adverse effects : Bicuculline, GABA Agents, Muscimol.
- drug effects : Behavior, Animal, Functional Laterality, Globus Pallidus, Reaction Time, Stereotyped Behavior, Subthalamic Nucleus.
- etiology : Movement Disorders.
- methods : Microinjections.
- pathology : Movement Disorders.
- physiology : Globus Pallidus, Stereotyped Behavior.
- physiopathology : Subthalamic Nucleus.
- Animals, Cercopithecus aethiops, Disease Models, Animal, Male.
Abstract
High-frequency stimulation of the subthalamic nucleus (STN) in parkinsonian patients is reported to induce psychiatric effects. The likely explanation for these effects is the partitioning of the STN into sensorimotor, associative, and limbic anatomo-functional territories. Thus, a specific neuronal dysfunction of the STN sensorimotor territory could lead to abnormal movements, whereas a dysfunction of the associative or limbic territory could lead to behavioral disturbances. To test this hypothesis, neuronal dysfunction of the STN was induced by microinjections of the GABA agonist muscimol, or antagonist bicucculline, in various parts of the nucleus in three monkeys. Stereotyped behaviors (licking and biting fingers) and/or violent hyperactivity were obtained with bicuculline injected into the anteromedial, associative, and limbic territories, whereas injections of muscimol induced no major effects. Abnormal limb movements (contralateral ballism) were obtained after muscimol or bicuculline injections into the posterolateral, sensorimotor territory. Control injections localized around the STN induced other effects (mainly torticollis), which underlines the specificity of STN injection effects. Our study supports the hypothesis that the anteromedial part of the STN is involved in behavioral control.
DOI: 10.1002/mds.22547
PubMed: 19412950
Links to Exploration step
pubmed:19412950Le document en format XML
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Hirsch</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22547</idno><idno type="RBID">pubmed:19412950</idno><idno type="pmid">19412950</idno><idno type="wicri:Area/PubMed/Corpus">001D30</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys.</title><author><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name><affiliation><nlm:affiliation>INSERM, UMR_S679, Neurology and Experimental Therapeutics, Paris, France. carine.karachi@gmail.com</nlm:affiliation></affiliation></author><author><name sortKey="Grabli, David" sort="Grabli, David" uniqKey="Grabli D" first="David" last="Grabli">David Grabli</name></author><author><name sortKey="Baup, Nicolas" sort="Baup, Nicolas" uniqKey="Baup N" first="Nicolas" last="Baup">Nicolas Baup</name></author><author><name sortKey="Mounayar, Stephanie" sort="Mounayar, Stephanie" uniqKey="Mounayar S" first="Stéphanie" last="Mounayar">Stéphanie Mounayar</name></author><author><name sortKey="Tande, Dominique" sort="Tande, Dominique" uniqKey="Tande D" first="Dominique" last="Tandé">Dominique Tandé</name></author><author><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. Hirsch</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Behavior, Animal (drug effects)</term><term>Bicuculline (adverse effects)</term><term>Cercopithecus aethiops</term><term>Disease Models, Animal</term><term>Functional Laterality (drug effects)</term><term>GABA Agents (adverse effects)</term><term>Globus Pallidus (drug effects)</term><term>Globus Pallidus (physiology)</term><term>Male</term><term>Microinjections (methods)</term><term>Movement Disorders (etiology)</term><term>Movement Disorders (pathology)</term><term>Muscimol (adverse effects)</term><term>Reaction Time (drug effects)</term><term>Stereotyped Behavior (drug effects)</term><term>Stereotyped Behavior (physiology)</term><term>Subthalamic Nucleus (drug effects)</term><term>Subthalamic Nucleus (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Bicuculline</term><term>GABA Agents</term><term>Muscimol</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Behavior, Animal</term><term>Functional Laterality</term><term>Globus Pallidus</term><term>Reaction Time</term><term>Stereotyped Behavior</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Microinjections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Globus Pallidus</term><term>Stereotyped Behavior</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cercopithecus aethiops</term><term>Disease Models, Animal</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High-frequency stimulation of the subthalamic nucleus (STN) in parkinsonian patients is reported to induce psychiatric effects. The likely explanation for these effects is the partitioning of the STN into sensorimotor, associative, and limbic anatomo-functional territories. Thus, a specific neuronal dysfunction of the STN sensorimotor territory could lead to abnormal movements, whereas a dysfunction of the associative or limbic territory could lead to behavioral disturbances. To test this hypothesis, neuronal dysfunction of the STN was induced by microinjections of the GABA agonist muscimol, or antagonist bicucculline, in various parts of the nucleus in three monkeys. Stereotyped behaviors (licking and biting fingers) and/or violent hyperactivity were obtained with bicuculline injected into the anteromedial, associative, and limbic territories, whereas injections of muscimol induced no major effects. Abnormal limb movements (contralateral ballism) were obtained after muscimol or bicuculline injections into the posterolateral, sensorimotor territory. Control injections localized around the STN induced other effects (mainly torticollis), which underlines the specificity of STN injection effects. Our study supports the hypothesis that the anteromedial part of the STN is involved in behavioral control.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19412950</PMID><DateCreated><Year>2009</Year><Month>06</Month><Day>29</Day></DateCreated><DateCompleted><Year>2009</Year><Month>09</Month><Day>17</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>8</Issue><PubDate><Year>2009</Year><Month>Jun</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys.</ArticleTitle><Pagination><MedlinePgn>1183-92</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22547</ELocationID><Abstract><AbstractText>High-frequency stimulation of the subthalamic nucleus (STN) in parkinsonian patients is reported to induce psychiatric effects. The likely explanation for these effects is the partitioning of the STN into sensorimotor, associative, and limbic anatomo-functional territories. Thus, a specific neuronal dysfunction of the STN sensorimotor territory could lead to abnormal movements, whereas a dysfunction of the associative or limbic territory could lead to behavioral disturbances. To test this hypothesis, neuronal dysfunction of the STN was induced by microinjections of the GABA agonist muscimol, or antagonist bicucculline, in various parts of the nucleus in three monkeys. Stereotyped behaviors (licking and biting fingers) and/or violent hyperactivity were obtained with bicuculline injected into the anteromedial, associative, and limbic territories, whereas injections of muscimol induced no major effects. Abnormal limb movements (contralateral ballism) were obtained after muscimol or bicuculline injections into the posterolateral, sensorimotor territory. Control injections localized around the STN induced other effects (mainly torticollis), which underlines the specificity of STN injection effects. 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ValidYN="Y"><LastName>François</LastName><ForeName>Chantal</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Hirsch</LastName><ForeName>Etienne C</ForeName><Initials>EC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018682">GABA Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>2763-96-4</RegistryNumber><NameOfSubstance UI="D009118">Muscimol</NameOfSubstance></Chemical><Chemical><RegistryNumber>Y37615DVKC</RegistryNumber><NameOfSubstance 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