Muscle biopsy substantiates long-term MRI alterations one year after a single dose of botulinum toxin injected into the lateral gastrocnemius muscle of healthy volunteers.
Identifieur interne : 001C82 ( PubMed/Corpus ); précédent : 001C81; suivant : 001C83Muscle biopsy substantiates long-term MRI alterations one year after a single dose of botulinum toxin injected into the lateral gastrocnemius muscle of healthy volunteers.
Auteurs : A Sebastian Schroeder ; Birgit Ertl-Wagner ; Stefanie Britsch ; J Michael Schröder ; Stefan Nikolin ; Joachim Weis ; Wolfgang Müller-Felber ; Inga Koerte ; Maximilian Stehr ; Steffen Berweck ; Ingo Borggraefe ; Florian HeinenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Adult, Anti-Dyskinesia Agents (pharmacology), Biopsy (methods), Botulinum Toxins (pharmacology), Double-Blind Method, Humans, Magnetic Resonance Imaging (methods), Male, Microscopy, Electron, Transmission (methods), Middle Aged, Muscle, Skeletal (anatomy & histology), Muscle, Skeletal (drug effects), Muscle, Skeletal (ultrastructure), Prospective Studies.
- MESH :
- chemical , pharmacology : Anti-Dyskinesia Agents, Botulinum Toxins.
- anatomy & histology : Muscle, Skeletal.
- drug effects : Muscle, Skeletal.
- methods : Biopsy, Magnetic Resonance Imaging, Microscopy, Electron, Transmission.
- ultrastructure : Muscle, Skeletal.
- Adult, Double-Blind Method, Humans, Male, Middle Aged, Prospective Studies.
Abstract
Despite numerous clinical and experimental studies on botulinum toxin type A (BoNT/A), long-term alterations of muscle texture and fine structure following BoNT/A treatment have thus far not been studied in normal human skeletal muscle. After obtaining institutional review board approval, we performed a prospective, placebo-controlled, double-blinded follow-up study on two healthy adults using magnetic resonance imaging (MRI) and muscle biopsy to visualize long-term alterations after a single BoNT/A injection into the lateral head of the gastrocnemius muscle. MRI disclosed a high-signal-intensity pattern in short tau inversion recovery sequences, and a reduction of the cross-sectional area in the BoNT/A-injected, but not in the saline-injected contralateral control muscle (at 6 to 9 months in volunteer A: 73%, in B: 62%; at 12 months in A: 88%, and in B: 78%). Enzyme histochemistry, 12 months after injection, confirmed neurogenic atrophy of muscle fibers only in the BoNT/A-injected muscle. Electron microscopy revealed additional degenerative changes at the neuromuscular junction. The data confirm that MRI is a suitable tool to monitor the long-term effect of BoNT/A on skeletal muscle. Neurogenic muscle atrophy following a single BoNT/A injection should be taken into consideration when repeated BoNT/A injections into the same muscles are proposed.
DOI: 10.1002/mds.22661
PubMed: 19489066
Links to Exploration step
pubmed:19489066Le document en format XML
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sortKey="Schroder, J Michael" sort="Schroder, J Michael" uniqKey="Schroder J" first="J Michael" last="Schröder">J Michael Schröder</name></author><author><name sortKey="Nikolin, Stefan" sort="Nikolin, Stefan" uniqKey="Nikolin S" first="Stefan" last="Nikolin">Stefan Nikolin</name></author><author><name sortKey="Weis, Joachim" sort="Weis, Joachim" uniqKey="Weis J" first="Joachim" last="Weis">Joachim Weis</name></author><author><name sortKey="Muller Felber, Wolfgang" sort="Muller Felber, Wolfgang" uniqKey="Muller Felber W" first="Wolfgang" last="Müller-Felber">Wolfgang Müller-Felber</name></author><author><name sortKey="Koerte, Inga" sort="Koerte, Inga" uniqKey="Koerte I" first="Inga" last="Koerte">Inga Koerte</name></author><author><name sortKey="Stehr, Maximilian" sort="Stehr, Maximilian" uniqKey="Stehr M" first="Maximilian" last="Stehr">Maximilian Stehr</name></author><author><name sortKey="Berweck, Steffen" sort="Berweck, Steffen" uniqKey="Berweck S" first="Steffen" last="Berweck">Steffen Berweck</name></author><author><name sortKey="Borggraefe, Ingo" sort="Borggraefe, Ingo" uniqKey="Borggraefe I" first="Ingo" last="Borggraefe">Ingo Borggraefe</name></author><author><name sortKey="Heinen, Florian" sort="Heinen, Florian" uniqKey="Heinen F" first="Florian" last="Heinen">Florian Heinen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22661</idno><idno type="RBID">pubmed:19489066</idno><idno type="pmid">19489066</idno><idno type="wicri:Area/PubMed/Corpus">001C82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Muscle biopsy substantiates long-term MRI alterations one year after a single dose of botulinum toxin injected into the lateral gastrocnemius muscle of healthy volunteers.</title><author><name sortKey="Schroeder, A Sebastian" sort="Schroeder, A Sebastian" uniqKey="Schroeder A" first="A Sebastian" last="Schroeder">A Sebastian Schroeder</name><affiliation><nlm:affiliation>Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner's Children's Hospital, University of Munich, Munich, Germany. sebastian.schroeder@med.uni-muenchen.de</nlm:affiliation></affiliation></author><author><name sortKey="Ertl Wagner, Birgit" sort="Ertl Wagner, Birgit" uniqKey="Ertl Wagner B" first="Birgit" last="Ertl-Wagner">Birgit Ertl-Wagner</name></author><author><name sortKey="Britsch, Stefanie" sort="Britsch, Stefanie" uniqKey="Britsch S" first="Stefanie" last="Britsch">Stefanie Britsch</name></author><author><name sortKey="Schroder, J Michael" sort="Schroder, J Michael" uniqKey="Schroder J" first="J Michael" last="Schröder">J Michael Schröder</name></author><author><name sortKey="Nikolin, Stefan" sort="Nikolin, Stefan" uniqKey="Nikolin S" first="Stefan" last="Nikolin">Stefan Nikolin</name></author><author><name sortKey="Weis, Joachim" sort="Weis, Joachim" uniqKey="Weis J" first="Joachim" last="Weis">Joachim Weis</name></author><author><name sortKey="Muller Felber, Wolfgang" sort="Muller Felber, Wolfgang" uniqKey="Muller Felber W" first="Wolfgang" last="Müller-Felber">Wolfgang Müller-Felber</name></author><author><name sortKey="Koerte, Inga" sort="Koerte, Inga" uniqKey="Koerte I" first="Inga" last="Koerte">Inga Koerte</name></author><author><name sortKey="Stehr, Maximilian" sort="Stehr, Maximilian" uniqKey="Stehr M" first="Maximilian" last="Stehr">Maximilian Stehr</name></author><author><name sortKey="Berweck, Steffen" sort="Berweck, Steffen" uniqKey="Berweck S" first="Steffen" last="Berweck">Steffen Berweck</name></author><author><name sortKey="Borggraefe, Ingo" sort="Borggraefe, Ingo" uniqKey="Borggraefe I" first="Ingo" last="Borggraefe">Ingo Borggraefe</name></author><author><name sortKey="Heinen, Florian" sort="Heinen, Florian" uniqKey="Heinen F" first="Florian" last="Heinen">Florian Heinen</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anti-Dyskinesia Agents (pharmacology)</term><term>Biopsy (methods)</term><term>Botulinum Toxins (pharmacology)</term><term>Double-Blind Method</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Microscopy, Electron, Transmission (methods)</term><term>Middle Aged</term><term>Muscle, Skeletal (anatomy & histology)</term><term>Muscle, Skeletal (drug effects)</term><term>Muscle, Skeletal (ultrastructure)</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biopsy</term><term>Magnetic Resonance Imaging</term><term>Microscopy, Electron, Transmission</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite numerous clinical and experimental studies on botulinum toxin type A (BoNT/A), long-term alterations of muscle texture and fine structure following BoNT/A treatment have thus far not been studied in normal human skeletal muscle. After obtaining institutional review board approval, we performed a prospective, placebo-controlled, double-blinded follow-up study on two healthy adults using magnetic resonance imaging (MRI) and muscle biopsy to visualize long-term alterations after a single BoNT/A injection into the lateral head of the gastrocnemius muscle. MRI disclosed a high-signal-intensity pattern in short tau inversion recovery sequences, and a reduction of the cross-sectional area in the BoNT/A-injected, but not in the saline-injected contralateral control muscle (at 6 to 9 months in volunteer A: 73%, in B: 62%; at 12 months in A: 88%, and in B: 78%). Enzyme histochemistry, 12 months after injection, confirmed neurogenic atrophy of muscle fibers only in the BoNT/A-injected muscle. Electron microscopy revealed additional degenerative changes at the neuromuscular junction. The data confirm that MRI is a suitable tool to monitor the long-term effect of BoNT/A on skeletal muscle. Neurogenic muscle atrophy following a single BoNT/A injection should be taken into consideration when repeated BoNT/A injections into the same muscles are proposed.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19489066</PMID><DateCreated><Year>2009</Year><Month>08</Month><Day>03</Day></DateCreated><DateCompleted><Year>2009</Year><Month>10</Month><Day>22</Day></DateCompleted><DateRevised><Year>2010</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>10</Issue><PubDate><Year>2009</Year><Month>Jul</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Muscle biopsy substantiates long-term MRI alterations one year after a single dose of botulinum toxin injected into the lateral gastrocnemius muscle of healthy volunteers.</ArticleTitle><Pagination><MedlinePgn>1494-503</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22661</ELocationID><Abstract><AbstractText>Despite numerous clinical and experimental studies on botulinum toxin type A (BoNT/A), long-term alterations of muscle texture and fine structure following BoNT/A treatment have thus far not been studied in normal human skeletal muscle. After obtaining institutional review board approval, we performed a prospective, placebo-controlled, double-blinded follow-up study on two healthy adults using magnetic resonance imaging (MRI) and muscle biopsy to visualize long-term alterations after a single BoNT/A injection into the lateral head of the gastrocnemius muscle. MRI disclosed a high-signal-intensity pattern in short tau inversion recovery sequences, and a reduction of the cross-sectional area in the BoNT/A-injected, but not in the saline-injected contralateral control muscle (at 6 to 9 months in volunteer A: 73%, in B: 62%; at 12 months in A: 88%, and in B: 78%). Enzyme histochemistry, 12 months after injection, confirmed neurogenic atrophy of muscle fibers only in the BoNT/A-injected muscle. Electron microscopy revealed additional degenerative changes at the neuromuscular junction. The data confirm that MRI is a suitable tool to monitor the long-term effect of BoNT/A on skeletal muscle. Neurogenic muscle atrophy following a single BoNT/A injection should be taken into consideration when repeated BoNT/A injections into the same muscles are proposed.</AbstractText><CopyrightInformation>Copyright 2009 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schroeder</LastName><ForeName>A Sebastian</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner's Children's Hospital, University of Munich, Munich, Germany. sebastian.schroeder@med.uni-muenchen.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ertl-Wagner</LastName><ForeName>Birgit</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Britsch</LastName><ForeName>Stefanie</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Schröder</LastName><ForeName>J Michael</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Nikolin</LastName><ForeName>Stefan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Weis</LastName><ForeName>Joachim</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Müller-Felber</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Koerte</LastName><ForeName>Inga</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Stehr</LastName><ForeName>Maximilian</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Berweck</LastName><ForeName>Steffen</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Borggraefe</LastName><ForeName>Ingo</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Heinen</LastName><ForeName>Florian</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018726">Anti-Dyskinesia Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.24.69</RegistryNumber><NameOfSubstance UI="D001905">Botulinum Toxins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018726">Anti-Dyskinesia Agents</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001706">Biopsy</DescriptorName><QualifierName MajorTopicYN="N" 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Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018482">Muscle, Skeletal</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000033">anatomy & histology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000648">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011446">Prospective Studies</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>6</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>6</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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