MovDisordV3, PubMed, Corpus, bibRecord, 001B49

Positive family history of essential tremor influences the motor phenotype of Parkinson's disease.

Identifieur interne : 001B49 ( PubMed/Corpus ); précédent : 001B48; suivant : 001B50

Positive family history of essential tremor influences the motor phenotype of Parkinson's disease.

Auteurs : Peter Hedera ; John Y. Fang ; Fenna Phibbs ; Michael K. Cooper ; P David Charles ; Thomas L. Davis

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.

RBID : pubmed:19795470

English descriptors

KwdEn :
- Aged, Disability Evaluation, Essential Tremor (complications), Family Health, Female, Humans, Male, Middle Aged, Parkinson Disease (etiology), Phenotype, Postural Balance (physiology), Risk Factors, Severity of Illness Index.
MESH :
- complications : Essential Tremor.
- etiology : Parkinson Disease.
- physiology : Postural Balance.
- Aged, Disability Evaluation, Family Health, Female, Humans, Male, Middle Aged, Phenotype, Risk Factors, Severity of Illness Index.

Abstract

Previous reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long-standing ET who develop PD tend to have a tremor-dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor-predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (r = 0.83, P < 0.001). Tremor-dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD.

DOI: 10.1002/mds.22772
PubMed: 19795470

Links to Exploration step

pubmed:19795470

Le document en format XML

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<author><name sortKey="Hedera, Peter" sort="Hedera, Peter" uniqKey="Hedera P" first="Peter" last="Hedera">Peter Hedera</name>
<affiliation><nlm:affiliation>Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232-8522, USA. peter.hedera@vanderbilt.edu</nlm:affiliation>
</affiliation>
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<author><name sortKey="Fang, John Y" sort="Fang, John Y" uniqKey="Fang J" first="John Y" last="Fang">John Y. Fang</name>
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<author><name sortKey="Phibbs, Fenna" sort="Phibbs, Fenna" uniqKey="Phibbs F" first="Fenna" last="Phibbs">Fenna Phibbs</name>
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<author><name sortKey="Cooper, Michael K" sort="Cooper, Michael K" uniqKey="Cooper M" first="Michael K" last="Cooper">Michael K. Cooper</name>
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<author><name sortKey="Charles, P David" sort="Charles, P David" uniqKey="Charles P" first="P David" last="Charles">P David Charles</name>
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<author><name sortKey="Davis, Thomas L" sort="Davis, Thomas L" uniqKey="Davis T" first="Thomas L" last="Davis">Thomas L. Davis</name>
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<author><name sortKey="Fang, John Y" sort="Fang, John Y" uniqKey="Fang J" first="John Y" last="Fang">John Y. Fang</name>
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<author><name sortKey="Charles, P David" sort="Charles, P David" uniqKey="Charles P" first="P David" last="Charles">P David Charles</name>
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<author><name sortKey="Davis, Thomas L" sort="Davis, Thomas L" uniqKey="Davis T" first="Thomas L" last="Davis">Thomas L. Davis</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Disability Evaluation</term>
<term>Essential Tremor (complications)</term>
<term>Family Health</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (etiology)</term>
<term>Phenotype</term>
<term>Postural Balance (physiology)</term>
<term>Risk Factors</term>
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<term>Disability Evaluation</term>
<term>Family Health</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">Previous reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long-standing ET who develop PD tend to have a tremor-dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor-predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (r = 0.83, P < 0.001). Tremor-dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD.</div>
</front>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<Abstract><AbstractText>Previous reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long-standing ET who develop PD tend to have a tremor-dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor-predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (r = 0.83, P < 0.001). Tremor-dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD.</AbstractText>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D004856">Postural Balance</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Positive family history of essential tremor influences the motor phenotype of Parkinson's disease.

Positive family history of essential tremor influences the motor phenotype of Parkinson's disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki