Topographical distribution of cerebral cortical thinning in patients with mild Parkinson's disease without dementia.
Identifieur interne : 001A04 ( PubMed/Corpus ); précédent : 001A03; suivant : 001A05Topographical distribution of cerebral cortical thinning in patients with mild Parkinson's disease without dementia.
Auteurs : Chul Hyoung Lyoo ; Young Hoon Ryu ; Myung Sik LeeSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Atrophy (epidemiology), Atrophy (pathology), Brain Mapping (methods), Cerebral Cortex (anatomy & histology), Cerebral Cortex (pathology), Dementia (diagnosis), Dementia (epidemiology), Disease Progression, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (epidemiology), Parkinson Disease (pathology).
- MESH :
- anatomy & histology : Cerebral Cortex.
- diagnosis : Dementia.
- epidemiology : Atrophy, Dementia, Parkinson Disease.
- methods : Brain Mapping.
- pathology : Atrophy, Cerebral Cortex, Parkinson Disease.
- Adult, Age of Onset, Aged, Disease Progression, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
The pathology of Parkinson's disease (PD) is not confined to the brainstem regions, but spreads to involve the neocortical areas. Using surface-based cortical thickness analysis, we studied the topographical distribution of cortical thinning in nondemented patients with mild PD. The high-resolution magnetic resonance imaging (MRI) studies were performed in 48 patients with PD without dementia and 56 age-matched healthy controls. Using the Freesurfer software, surface-based analysis was done to find changes in cerebral cortical thickness in patients with PD. Compared to the controls, patients with PD showed significant cortical thinning in the temporal, inferior parietal, rostral frontal, and orbitofrontal cortical areas. Thinning of the cerebral cortex occurs even in nondemented patients with mild PD, and its topographical distribution was similar to that of the neocortical Lewy bodies. Further studies are needed to find pathological and clinical correlates of thinned cerebral cortex found in nondemented patients with mild PD.
DOI: 10.1002/mds.22975
PubMed: 20108369
Links to Exploration step
pubmed:20108369Le document en format XML
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<author><name sortKey="Lyoo, Chul Hyoung" sort="Lyoo, Chul Hyoung" uniqKey="Lyoo C" first="Chul Hyoung" last="Lyoo">Chul Hyoung Lyoo</name>
<affiliation><nlm:affiliation>Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation>
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<author><name sortKey="Ryu, Young Hoon" sort="Ryu, Young Hoon" uniqKey="Ryu Y" first="Young Hoon" last="Ryu">Young Hoon Ryu</name>
</author>
<author><name sortKey="Lee, Myung Sik" sort="Lee, Myung Sik" uniqKey="Lee M" first="Myung Sik" last="Lee">Myung Sik Lee</name>
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<author><name sortKey="Ryu, Young Hoon" sort="Ryu, Young Hoon" uniqKey="Ryu Y" first="Young Hoon" last="Ryu">Young Hoon Ryu</name>
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<author><name sortKey="Lee, Myung Sik" sort="Lee, Myung Sik" uniqKey="Lee M" first="Myung Sik" last="Lee">Myung Sik Lee</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Age of Onset</term>
<term>Aged</term>
<term>Atrophy (epidemiology)</term>
<term>Atrophy (pathology)</term>
<term>Brain Mapping (methods)</term>
<term>Cerebral Cortex (anatomy & histology)</term>
<term>Cerebral Cortex (pathology)</term>
<term>Dementia (diagnosis)</term>
<term>Dementia (epidemiology)</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (pathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Cerebral Cortex</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dementia</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Atrophy</term>
<term>Dementia</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Brain Mapping</term>
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<term>Disease Progression</term>
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<front><div type="abstract" xml:lang="en">The pathology of Parkinson's disease (PD) is not confined to the brainstem regions, but spreads to involve the neocortical areas. Using surface-based cortical thickness analysis, we studied the topographical distribution of cortical thinning in nondemented patients with mild PD. The high-resolution magnetic resonance imaging (MRI) studies were performed in 48 patients with PD without dementia and 56 age-matched healthy controls. Using the Freesurfer software, surface-based analysis was done to find changes in cerebral cortical thickness in patients with PD. Compared to the controls, patients with PD showed significant cortical thinning in the temporal, inferior parietal, rostral frontal, and orbitofrontal cortical areas. Thinning of the cerebral cortex occurs even in nondemented patients with mild PD, and its topographical distribution was similar to that of the neocortical Lewy bodies. Further studies are needed to find pathological and clinical correlates of thinned cerebral cortex found in nondemented patients with mild PD.</div>
</front>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<Abstract><AbstractText>The pathology of Parkinson's disease (PD) is not confined to the brainstem regions, but spreads to involve the neocortical areas. Using surface-based cortical thickness analysis, we studied the topographical distribution of cortical thinning in nondemented patients with mild PD. The high-resolution magnetic resonance imaging (MRI) studies were performed in 48 patients with PD without dementia and 56 age-matched healthy controls. Using the Freesurfer software, surface-based analysis was done to find changes in cerebral cortical thickness in patients with PD. Compared to the controls, patients with PD showed significant cortical thinning in the temporal, inferior parietal, rostral frontal, and orbitofrontal cortical areas. Thinning of the cerebral cortex occurs even in nondemented patients with mild PD, and its topographical distribution was similar to that of the neocortical Lewy bodies. Further studies are needed to find pathological and clinical correlates of thinned cerebral cortex found in nondemented patients with mild PD.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lyoo</LastName>
<ForeName>Chul Hyoung</ForeName>
<Initials>CH</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.</Affiliation>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName>
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