Gray matter correlations of cognition in incident Parkinson's disease.
Identifieur interne : 001903 ( PubMed/Corpus ); précédent : 001902; suivant : 001904Gray matter correlations of cognition in incident Parkinson's disease.
Auteurs : Turi O. Dalaker ; Robert Zivadinov ; Jan P. Larsen ; Mona K. Beyer ; Jennifer L. Cox ; Guido Alves ; Kolbjorn Bronnick ; Ole-Bjorn Tysnes ; Ronald Antulov ; Michael G. Dwyer ; Dag AarslandSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Cognition Disorders.
- methods : Magnetic Resonance Imaging.
- pathology : Brain, Cognition Disorders.
- Aged, Brain Mapping, Community Health Planning, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies.
Abstract
We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region-specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel-based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD.
DOI: 10.1002/mds.22867
PubMed: 20213820
Links to Exploration step
pubmed:20213820Le document en format XML
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<author><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name>
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<author><name sortKey="Tysnes, Ole Bjorn" sort="Tysnes, Ole Bjorn" uniqKey="Tysnes O" first="Ole-Bjorn" last="Tysnes">Ole-Bjorn Tysnes</name>
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<front><div type="abstract" xml:lang="en">We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region-specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel-based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD.</div>
</front>
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<Abstract><AbstractText>We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region-specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel-based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD.</AbstractText>
<CopyrightInformation>(c) 2010 Movement Disorder Society.</CopyrightInformation>
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